The Structural Biology Shared Facility supports cancer investigators with cutting-edge technology to elucidate structure-function relationships of macromolecules. The state-of-the-art research instrumentation capabilities include a Bruker-Biospin Avance III HD 850 MHz NMR spectrometer with a TCI-cryoprobe, a high intensity X-ray system with Pilatus multi-wire and R-axis IV++ detectors, two Fomulatrix crystal imaging systems to support 20o and 4o degree crystallization and imaging, and a powerful optical system that can detect protein crystals less than 1 micron in size.

The SBSF team:

  • Maintains and provides access to state-of-the-art X-ray crystallography, NMR, biophysical instrumentation, and computer modeling capabilities, including structure-based virtual screening of chemical compound libraries
  • Provides expertise to investigators through service, consultation, education and training in protein crystallization, X-ray structure determination, and high-field NMR applications in structural biology, drug discovery, and cancer metabolomics by NMR
  • Continues structure-based approaches to improve compounds being designed and synthesized by medical chemists at UAB and Southern Research for cancer-related projects in order to produce new compounds appropriate for clinical trials

Leadership

Champion Deivanayagam headshot

Champion Deivanayagam, Ph.D. Co-Director
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William Placzek headshot

William Placzek, Ph.D. Co-Director
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