Faculty Member: Lewis Zhichang Shi, MD, PhD,  Associate Professor, Dept Radiation Oncology, Microbiology & Immunology, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35233 lshi@uab.edu 

Postdoctoral Scholarships are available in the laboratory of Dr. Lewis Zhichang Shi, to investigate the underlying mechanisms for cancer immunotherapy, particularly immune checkpoint blockade (ICBs such as anti-CTLA-4 and anti-PD-1/-L1) that won the 2018 Nobel Prize.  We are also interested in identifying new targets for cancer interventions that can be utilized the setting of ICB and adoptive T cell therapy (e.g., CAR-T). Our recent work revealed tumor cell-intrinsic (Cell 167: 397 (2016)) and –extrinsic (Nat. Med. 23: 551 (2017)) resistant mechanisms, as well as T cell-intrinsic functional pathways underlying ICBs (Nat. Commun 7: 1 (2016)). Another line of research in the lab is to understand how T cell development, activation, and functional differentiation are transcriptionally and metabolically controlled (PNAS (2013 and 2017), J Exp Med (2011), and Immunity (2011)). The experimental models include genetically-modified mice and mouse models for cancer, autoimmunity, infections, and inflammation. More information can be found at http://www.uab.edu/medicine/radonc/faculty/shi-lewis-zhichang OR https://www.uab.edu/medicine/immunology/faculty?id=253:schroeder&catid=39:faculty

Job Qualifications:
Highly motivated individuals with a recent Ph.D. in immunology, cancer biology, or molecular biology are encouraged to apply.

Application Instructions:
Please send a CV, including contact information for three references, to lshi@uab.edu.

University of Alabama at Birmingham (UAB) is an Equal Opportunity Employer. UAB is an Equal Opportunity/Affirmative Action Employer committed to fostering a diverse, equitable and family-friendly environment in which all faculty and staff can excel and achieve work/life balance irrespective of race, national origin, age, genetic or family medical history, gender, faith, gender identity and expression as well as sexual orientation. UAB also encourages applications from individuals with disabilities and veterans. UAB Comprehensive Cancer Center is one of the nation’s leading cancer research and treatment centers and the only National Cancer Institute-designated comprehensive cancer center located in a four-state area that includes Alabama, Mississippi, Louisiana and Arkansas. UAB’s cancer services are routinely recognized as being among the nation’s best.

About the University:

UAB pursues the frontiers of education, research and health care and strives to be one of the most dynamic and productive universities of the 21st century. Our strategic plan, Forging the Future, is our roadmap for the next five years of growth. It outlines goals that share three themes: increasing access to our world-class educational programs, patient care, and research; enhancing the alignment of people and programs to reflect the interdisciplinary nature of 21st-century curricula, scientific investigation, and creative scholarship; and investing in grand ideas to tackle major problems facing society.

The University of Alabama at Birmingham is an Equal Opportunity/Affirmative Action Employer committed to fostering a diverse, equitable and family-friendly environment in which all faculty and staff can excel and achieve work/life balance irrespective of, race, national origin, age, genetic or family medical history, gender, faith, gender identity and expression as well as sexual orientation. UAB also encourages applications from individuals with disabilities and veterans.

For more information on Equal Opportunity and Affirmative Action at UAB, visit the UAB Office of Diversity, Equity and Inclusion or call (205) 934-8762. Or contact the office at 701 20th Street South, AB 336, Birmingham, AL 35294-0103.

About our Postdoc office:

UAB is committed to the development and success of outstanding postdoctoral scientists. Here at UAB, nearly 300 postdoctoral fellows are training currently in a variety of disciplines, including dentistry, engineering, health professions, medicine, natural sciences and mathematics, public health, optometry, and social and behavioral sciences. Competitive postdoc awards are available including internships, grant incentives, funds to enhance education and collaboration outside UAB, and teaching opportunities at local universities. There is also a Postdoc Research Day with monetary awards. The OPE strongly encourages UAB research mentors to follow the National Research Service Award stipend level guidelines, and postdoctoral scholars qualify for health, life, and other insurances. They may also have the right to participate in the university’s 403(b) program and enjoy vacation, sick leave, maternity/paternity leave, and other benefits.