Mentor: Benjamin Larimer, PhD, Assistant Professor, Department of Radiology. blarimer@uab.edu.

A postdoctoral position is available in the Larimer Lab within the Department of Radiology and Comprehensive Cancer Center at the University of Alabama Birmingham (UAB) focusing on the discovery and development of novel biological agents. We have developed a humanized library of single domain antibodies (nanobodies) displayed on the surface of bacteriophage which we utilize to create proteins with the potential to characterize and treat cancer. The properties of nanobodies allow for unique biological applications, and our library provides a strategic opportunity to generate a new class of cancer therapeutics and imaging agents. UAB has a world-class NCI Comprehensive Cancer Center and Small Animal Imaging Facility which provide access to the resources necessary to apply developed nanobodies in cutting-edge models of cancer and immunotherapy. Our group collaborates with other top-tier academic research centers both nationally and internationally to apply our discoveries to a variety of leading cancer research.

We are seeking a candidate to select for clinically-translatable nanobodies against valuable cancer and immunological targets. Further, development and modification of select proteins is also desired in order to impart therapeutic or molecular imaging capabilities. Primarily, our group is focused on translational research and we have experience in bringing discoveries from animal models to clinical trial. The candidate will be supported in pursuit of clinical application of their discoveries as well as publication and generation of intellectual property based on their research. In addition to nanobody development candidates will receive mentoring in phage display, animal models of cancer and in vivo imaging.

Interested candidates should contact Benjamin Larimer with application information (CV, cover letter, references and possible start date) by email at blarimer@uab.edu.

Applicant Requirements:

  • PhD degree in Biochemistry, Chemistry, Biomedical Engineering or a related field.
  • Background in protein engineering and expression systems preferred.
  • Experience in antibody engineering desirable.
  • Strong experience in experimental design and written and oral communication.

About our Postdoc Office:

UAB is committed to the development and success of outstanding postdoctoral scientists. Here at UAB, nearly 300 postdoctoral fellows are training currently in a variety of disciplines. Competitive postdoc awards are available including internships, grant incentives, funds to enhance education and collaboration outside UAB, and teaching opportunities at local universities. There is also a Postdoc Research Day with monetary awards. The Office of Postdoctoral Education strongly encourages UAB research mentors to follow the National Research Service Award stipend level guidelines, and postdoctoral scholars qualify for health, life, and other insurances. They also have the right to participate in the university’s 403(b) program and enjoy vacation, sick leave, maternity/paternity leave, and other benefits.

About the University:

The University of Alabama at Birmingham (UAB) is a research university and academic health center that discovers, teaches, and applies knowledge for the intellectual, cultural, social, and economic benefit of Birmingham, the state, and beyond. UAB is internationally renowned for its intensely collaborative culture that has — for more than five decades — produced breakthroughs in education, health care, research, and service. UAB was ranked #1 in the United States, and in the top 10 worldwide, in the Times Higher Education World University Rankings, 2018 Young University Rankings.

Spanning more than 100 city blocks, UAB is the state of Alabama’s largest single employer with some 25,000 employees and has an annual, state-wide economic impact exceeding $7.15 billion. U.S. News & World Report’s 2020 “America’s Best Graduate Schools” ranks 14 UAB graduate programs among the nation’s top 25 and 10 UAB specialties were ranked among the nation’s top 50 in the magazine’s 2018-2019 Best Hospitals report. UAB research grants and awards are at a record high, exceeding $527 million in FY18, including $320 million in NIH funding for FY18. UAB ranks 31st among all universities in federal research funding and 15th among public universities. UAB's NIH funding continues to grow among peer institutions in the Southeast and beyond, with the university ranking 20th among all universities in NIH funding and eighth among public universities. The UAB School of Medicine is ranked 21st among medical schools in NIH funding and eighth among public medical schools.

UAB is an Equal Opportunity/Affirmative Action Employer committed to fostering a diverse, equitable and family-friendly environment in which all faculty and staff can excel and achieve work/life balance irrespective of, race, national origin, age, genetic or family medical history, gender, faith, gender identity, and expression as well as sexual orientation. UAB also encourages applications from individuals with disabilities and veterans.

For more information on Equal Opportunity and Affirmative Action at UAB, visit the UAB Office of Diversity, Equity and Inclusion or call (205) 934-8762. Or contact the office at 701 20th Street South, AB 336, Birmingham, AL 35294-0103.