Mentor: Dr. Josh Stern, PhD, Assistant Professor, School of Medicine (SOM), Department of Biochemistry and Molecular Genetics.         Email: jstern@uab.edu



A post-doctoral fellow position is immediately available in the Telomerase Regulation Lab under the direction of Dr. Josh Stern within the Department of Biochemistry and Molecular Genetics and UAB O’Neal Comprehensive Cancer Center.

The lab is seeking candidates with a background in cancer or stem cell biology, bioinformatics, biochemistry, or molecular biology. Prior experience working with stem cells, CRISPR genome engineering, RNAseq or ChIP-seq analysis, in vitro enzyme assays, multi-parameter flow cytometry, or fluorescence microscopy is desirable. The successful candidate will have excellent communication skills and the ability to design and perform experiments independently as well as part of a team, execute and prioritize multiple tasks simultaneous, develop and learn new techniques, critically interpret results, keep detailed experimental records, supervise and help train graduate students and technical staff, present data at conferences, and participate in the preparation of grant applications and publications.

The main focus of the lab is to understand telomerase regulation in normal and disease settings. Telomerase is abnormally activated in >85% of cancers and is pathologically inactivated in short telomere diseases. Telomerase activation in cancer licenses long-term growth and leads to fatal disease, while inactivation leads to premature aging conditions. Mutations in the gene promoter for telomerase are the most recurrent noncoding genetic abnormalities in cancer so far discovered and provide new opportunities for precision medicine. The lab takes a functional genomics approach, utilizing large datasets of genomic, proteomic, transcriptomic and epigenomic data to generate hypotheses about the regulation of telomerase which are then tested in cancer cells and normal cells. A key aim of the lab is to correct telomerase function where there is too little, or too much telomerase activity.

Please see the lab website for more details:

https://telomeraseregulation.org/

To apply, please submit the following documents to jstern@uab.edu:

  1. CV
  2. Cover letter
  3. Contact information for up to three professional references; references will not be contacted without prior notification of candidates.



About our Postdoc Office:

UAB is committed to the development and success of outstanding postdoctoral scientists. Here at UAB, nearly 300 postdoctoral fellows are training currently in a variety of disciplines. Competitive postdoc awards are available including internships, grant incentives, funds to enhance education and collaboration outside UAB, and teaching opportunities at local universities. There is also a Postdoc Research Day with monetary awards. The Office of Postdoctoral Education strongly encourages UAB research mentors to follow the National Research Service Award stipend level guidelines, and postdoctoral scholars qualify for health, life, and other insurances. They also have the right to participate in the university’s 403(b) program and enjoy vacation, sick leave, maternity/paternity leave, and other benefits.

About the University:

The University of Alabama at Birmingham (UAB) is a research university and academic health center that discovers, teaches, and applies knowledge for the intellectual, cultural, social, and economic benefit of Birmingham, the state, and beyond. UAB is internationally renowned for its intensely collaborative culture that has — for more than five decades — produced breakthroughs in education, health care, research, and service. UAB was ranked #1 in the United States, and in the top 10 worldwide, in the Times Higher Education World University Rankings, 2018 Young University Rankings.

The NCI-designated UAB Comprehensive Cancer Center is one of the nation's leading cancer research and treatment centers. Spanning more than 100 city blocks, UAB is the state of Alabama’s largest single employer with some 25,000 employees and has an annual, state-wide economic impact exceeding $7.15 billion. U.S. News & World Report’s 2020 “America’s Best Graduate Schools” ranks 14 UAB graduate programs among the nation’s top 25 and 10 UAB specialties were ranked among the nation’s top 50 in the magazine’s 2018-2019 Best Hospitals report. UAB research grants and awards are at a record high, exceeding $527 million in FY18, including $320 million in NIH funding for FY18. UAB ranks 31st among all universities in federal research funding and 15th among public universities. UAB's NIH funding continues to grow among peer institutions in the Southeast and beyond, with the university ranking 20th among all universities in NIH funding and eighth among public universities. The UAB School of Medicine is ranked 21st among medical schools in NIH funding and eighth among public medical schools.

UAB is an Equal Opportunity/Affirmative Action Employer committed to fostering a diverse, equitable and family-friendly environment in which all faculty and staff can excel and achieve work/life balance irrespective of, race, national origin, age, genetic or family medical history, gender, faith, gender identity, and expression as well as sexual orientation. UAB also encourages applications from individuals with disabilities and veterans.

For more information on Equal Opportunity and Affirmative Action at UAB, visit the UAB Office of Diversity, Equity and Inclusion or call (205) 934-8762. Or contact the office at 701 20th Street South, AB 336, Birmingham, AL 35294-0103.