A brown mouse.Inbred laboratory strains of mice are the most commonly used biomedical models and are used extensively in aging research. Weighing about the same as a naked mole-rat, the median lifespan of C57BL/6J mice is 866 days for females and 901 days for males.

Maximum lifespan for most strains is about four years; however, genetically altered strains such as the Ames dwarf mice have maximum lifespans approaching 5 years. That’s long for a mouse but extremely short for the similarly-sized naked mole-rat. Differences in life history and ecology between similar-sized animals lead to the evolution of divergent lifespans and can inform the basic biology of aging.
Two turquoise killifish swimming. The Turquoise Killifish (Nothobranchius furzeri) is the shortest-lived vertebrate currently bred in captivity. There are multiple strains in the wild showing significant variability in longevity and life history characteristics; several of these are maintained in captivity. The inbred GRZ strain is the shortest lived with a published median lifespan of 12-15 weeks and a maximum lifespan of 20 weeks in captivity. In contrast, the MZM strain has a maximum lifespan almost double that, at 203 days in captivity.

You can find more information on these animals in the NFIN website.

Photo: Mickie Powell