David Graves, Ph.D.

Research Description

My interests are in the area of physical biochemistry of nucleic acids and their interactions with small molecules, peptides and proteins.  Specifically, our studies focus on the structural and energetic features of nucleic acids and their complexes with other molecules.  We have used our studies to develop insights into the mechanisms of action of novel anticancer agents, and interactions of specific DNA structural motifs to elicit toll-like receptor mediated biological responses including innate cellular immunity and cancer cell metastasis.

Email: dgraves@uab.edu