Dr. Lubin's research is primarily directed towards characterizing the role of epigenetic mechanisms, such as histone modifications, DNA methylation, and signaling cascades that mediate the interaction of the NF-kB transcription factors to chromatin and determine how they participate in the regulation of gene expression as they relate to learning and memory and memory deficits associated with epilepsy. Her research program focuses on neurons and synapses in the hippocampus, an area of the brain that plays an important role in learning and memory and the development of epilepsy in humans. She is investigating the epigenetic regulation of brain derived neurotrophic factor (BDNF) transcripts during memory formation. This has lead to the discovery that exon-specific gene regulation of BDNF transcripts are dynamically regulated by DNA methylation and specific histone modifications in hippocampus during memory consolidation. Current work also includes an assessment of histone deacetylase (HDAC) inhibitors and demethylating agents that may be promising in the mitigation or disruption of cognitive changes that occur with epilepsy.