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Trauma is the leading cause of death in those under the age of 45. The most common cause of preventable death after injury is bleeding. Patients who are transported to the hospital with severe bleeding are normally given blood transfusions to replace the blood they have lost.
The purpose of this study is to determine whether patients who are injured and bleeding do better after receiving whole blood, or blood products (red cells, platelets and plasma). In the US, most blood that is donated is separated into blood products because it can be used to help more people that way. Therefore, many trauma patients receive blood products instead of whole blood. There is some evidence that whole blood might be more effective when treating trauma patients. However, we do not currently know whether whole blood or blood products are more helpful to people who need large amounts of blood after injury. The results of this study may be used to determine whether more whole blood will be made available for use in trauma patients.
Because blood transfusions must begin very soon after patients arrive at the hospital, most patients are not able to provide consent to enter a study. Therefore, this study will enroll participants without their consent.
This study is being conducted in 13 sites across the US, and will enroll 1,100 people.
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