For More information: High-Field Nuclear Magnetic Resonance Facility

Director, Dr. Rama Khrishna

Bruker Avance 850 MHz and 700 MHz NMR Systems with CryoProbes

High-Field NMR spectroscopy is a highly versatile tool useful in a wide range of structural biology applications. It can be used to determine the three dimensional structures of biological macromolecules, e.g., proteins (including membrane proteins), nucleic acids, complex carbohydrates, as well as their various complexes (e.g., protein-RNA) directly in solution under physiologically meaningful conditions. 

In addition, it allows a study of protein dynamics (including detection of excited states). Equally important applications of NMR spectroscopy include drug discovery and design, and NMR-metabolimics of biofluids.