The following courses have been developed or adapted for the UAB Hughes Med-Grad Fellowship. These courses are intended to reduce the intellectual distance between bench and bedside through instruction of medically-relevant, patient-oriented information by top physician-scientists. The didactic experience will provide a conduit for matching fellows with world-class mentors for thesis projects in contemporary disease-based research.
All UAB Hughes Med-Grad Scholars will matriculate through one of the existing interdisciplinary Ph.D. programs to fulfill their degree requirements.
Modeling Human Disease
A case-based, clinical pathological, conference-style course that will present relevant physical exam and laboratory data key to the diagnosis and clinical management of specific diseases. Fellows will team with mentors to present and discuss patients. A seminar will follow, led by a prominent researcher in the field, to highlight the molecular basis of the disease as well as the mechanism for diagnosis and treatment.
This course will cover disease processes, such as cancer metastasis, that will form the basis of modules for instruction in modern methodology (e.g., histological basis of the epithelial-mesenchymal transition, use of gene chips to identify global changes in gene expression, transgenic strategies targeting epithelial cells, introduction of imaging modalities to track metastatic cells, and visualizing lung/bone metastasis in human tissue).
Fellows will gain an understanding of the modern drug discovery process, including the steps from identification of lead targets to completion of clinical trials required for FDA approval. This course challenges fellows to think about how the molecule or pathway identified in their research could be targeted and validated.
HMG fellows wil become familiar with the principles and methods of clinical research and learn how to critically evaluate medical research literature and understand how clinical questions are framed, how studies are designed, and how knowledge is transferred to the bedside.