Center for Surgical Research
Director: Irshad H. Chaudry, Ph.D.
Mission and Demographics
The mission of the Center for Surgical Research is to foster research
and instruction in the areas of trauma, hemorrhage, sepsis, burn injury,
and surgical critical care and to translate these experimental studies
to the bedside using novel treatment modalities so that complications
and mortality rates in such trauma patients can be decreased. The Center
currently has 19 appointed faculty members representing 15 departments
and divisions at UAB.
General Research Interests
The Center for Surgical Research has the expertise, resources, facilities,
and environment to conduct research in both the basic and the clinical
sciences of trauma. Research
at the Center is multidisciplinary and includes investigators with specialties
microbiology, and molecular
biology. Only by interaction of these diverse areas of expertise,
is it possible to accomplish the goals of obtaining new and pertinent
information for better care and management of the traumatized host. Significant
emphasis is placed on generating state-of-the-art information that is
available to trauma and burn surgeons in the UAB community. Investigators
in Anesthesiology, Cardiovascular-Thoracic,
Surgery, Pathology, Pediatric
Care are a part of the Center for Surgical Research. The combined
team effort and integrative approach contribute to improved procedures
for diagnosis, treatment, and critical care that will result in decreased
trauma-induced septic complications, morbidities, and mortality rates.
Although the research interests in the Center for Surgical Research
are multifaceted, a particular area of emphasis is the gender
dimorphism in cardiovascular and immunological responses following tissue
trauma, hemorrhage, and thermal injury. There is also emphasis on
the use of sex steroid/receptor agonist/antagonist following trauma
to restore depressed cardiac and myocardial responses.
The National Institutes of Health (NIH)
is the major source of funding support for research at the Center for
Surgical Research. Dr. Chaudry, Director of the Center for Surgical
Research, has over 610-peer
reviewed publications to his credit and is also a recipient of a
Award from the NIH-National Institute of General Medical Sciences (NIGMS).
The Center for
Surgical Research received a grant from DARPA,
the Department of Defense agency renowned for funding high risk, high
impact research. This particular grant investigated a means to extend
the life of wounded soldiers who have sustained massive blood loss.
A matrix of compounds were examined in an animal model of "permissive
hypotension". The goal is to extend a wounded
soldier's survival after sustaining massive hemorrhage and shock
(still the major cause of battlefield death) by several hours, sufficient
to evacuate the soldier to a field hospital for treatment.
A grant from the U.S. Army MRAA
is exploring the use of 17β-estradiol
with and without other compounds in the treatment of traumatic
brain injury with an eye toward application in the civilian population
as well as on the battlefield.
The Center for Surgical Research is committed to the training of residents
Investigators at the Center for Surgical Research have trained and are
training several residents/fellows. Many of these trainees are now independent
investigators conducting research in the field of trauma both in the
U.S. and abroad. Dr. Chaudry is also the Program Director of a T32 grant
from the NIH/NIGMS.
In addition, the Center offers a two-year Post-Doctoral Fellowship program
in Trauma and Inflammation Research".
The Center for Surgical Research houses the Editor-in-Chief's office
and several editorial board members of the international journal, SHOCK.
Director: Irshad Chaudry
Administrative Associate: Connie
Secretary to Dr. Chaudry:
I. Bland, M.D.
E. Eckhoff, M.D.
Yancey Gillespie, Ph.D.
Grant, III, M.D.
Mac Harmon, M.D., Ph.D.
J. Hubbard, Ph.D.
Markert, M.D., MPH
L. Messina, Ph.D.
C. Naftel, Ph.D.
Rue, III, M.D.
Julie Gray, B.S.
Shunhua Hu, M.D.
Bixi Jian, Ph.D.
Miki Jinno, B.S.
Shaolong Yang, M.D.
Office of Postdoctoral Education
Faculty Position in Trauma and Shock Pathophysiology
Faculty Position in Trauma and Shock Immunopathophysiology
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