Center for Surgical Research

Director: Irshad H. Chaudry, Ph.D.
Established: November 17, 2000

Mission and Demographics
The mission of the Center for Surgical Research is to foster research and instruction in the areas of trauma, hemorrhage, sepsis, burn injury, and surgical critical care and to translate these experimental studies to the bedside using novel treatment modalities so that complications and mortality rates in such trauma patients can be decreased. The Center currently has 19 appointed faculty members representing 15 departments and divisions at UAB.

General Research Interests

The Center for Surgical Research has the expertise, resources, facilities, and environment to conduct research in both the basic and the clinical sciences of trauma. Research at the Center is multidisciplinary and includes investigators with specialties in surgery, medicine, physiology, pathology, biochemistry, immunology, microbiology, and molecular biology. Only by interaction of these diverse areas of expertise, is it possible to accomplish the goals of obtaining new and pertinent information for better care and management of the traumatized host. Significant emphasis is placed on generating state-of-the-art information that is available to trauma and burn surgeons in the UAB community. Investigators in Anesthesiology, Cardiovascular-Thoracic, General Surgery, Injury Sciences, Medicine, Microbiology, Neurosurgery, Orthopedic Surgery, Pathology, Pediatric Surgery, Plastic Surgery, Transplantation, Trauma, Burns, and Critical Care are a part of the Center for Surgical Research. The combined team effort and integrative approach contribute to improved procedures for diagnosis, treatment, and critical care that will result in decreased trauma-induced septic complications, morbidities, and mortality rates.

Although the research interests in the Center for Surgical Research are multifaceted, a particular area of emphasis is the gender dimorphism in cardiovascular and immunological responses following tissue trauma, hemorrhage, and thermal injury. There is also emphasis on the use of sex steroid/receptor agonist/antagonist following trauma to restore depressed cardiac and myocardial responses.

The National Institutes of Health (NIH) is the major source of funding support for research at the Center for Surgical Research. Dr. Chaudry, Director of the Center for Surgical Research, has over 610-peer reviewed publications to his credit and is also a recipient of a MERIT Award from the NIH-National Institute of General Medical Sciences (NIGMS).

The Center for Surgical Research received a grant from DARPA, the Department of Defense agency renowned for funding high risk, high impact research. This particular grant investigated a means to extend the life of wounded soldiers who have sustained massive blood loss. A matrix of compounds were examined in an animal model of "permissive hypotension". The goal is to extend a wounded soldier's survival after sustaining massive hemorrhage and shock (still the major cause of battlefield death) by several hours, sufficient to evacuate the soldier to a field hospital for treatment.

A grant from the U.S. Army MRAA is exploring the use of 17
β-estradiol with and without other compounds in the treatment of traumatic brain injury with an eye toward application in the civilian population as well as on the battlefield.

The Center for Surgical Research is committed to the training of residents and fellows. Investigators at the Center for Surgical Research have trained and are training several residents/fellows. Many of these trainees are now independent investigators conducting research in the field of trauma both in the U.S. and abroad. Dr. Chaudry is also the Program Director of a T32 grant from the NIH/NIGMS. In addition, the Center offers a two-year Post-Doctoral Fellowship program for "Training in Trauma and Inflammation Research".

Additional Information
The Center for Surgical Research houses the Editor-in-Chief's office and several editorial board members of the international journal, SHOCK.

Director: Irshad Chaudry
Phone: 205-975-2195

Administrative Associate: Connie Weldon
Phone: 205-975-9710

Secretary to Dr. Chaudry: Bobbi Smith

Webmaster: Dennis Campbell
Phone: 205-975-9717

For Comments or Questions, Please Contact Us;


Irshad Chaudry, Ph.D.

Faculty Members:
Kirby I. Bland, M.D.
Devin E. Eckhoff, M.D.
James George, Ph.D.
G. Yancey Gillespie, Ph.D.
John Grant, III, M.D.
C. Mac Harmon, M.D., Ph.D.
Marty Heslin, M.D.
William Holman, M.D.
William J. Hubbard, Ph.D.
James Markert, M.D., MPH
Sadis Matalon, Ph.D.
Joseph L. Messina, Ph.D.
David C. Naftel, Ph.D.
Suzanne Oparil, M.D.
Raghavan Raju, Ph.D.
Loring Rue, III, M.D.
Anthony Thompson, Ph.D.
David Volgas, M.D.

Research Staff:

Ahmar Ayub, D.V.M.
Julie Gray, B.S.
Shunhua Hu, M.D.
Bixi Jian, Ph.D.
Miki Jinno, B.S.

Shaolong Yang, M.D.

Training Opportunities

UAB Office of Postdoctoral Education

Postdoctoral Fellowship

Junior/Senior Faculty Position in Trauma and Shock Pathophysiology

Junior/Senior Faculty Position in Trauma and Shock Immunopathophysiology

Welcome to Birmingham

Check your UAB email

UAB Emergency Alert System