FACTOR V LEIDEN MUTATION  Email this article
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Primary Name Factor V Leiden mutation
Synonym Factor V gene mutation
Synonym Leiden gene mutation
Contraction FVL
Contraction Occasionally confused with factor V activity
Contraction --
UAB Procedure Number 3503050
CPT Code 83891, 83892, 83896´2, 83903´2, 83912
Specimen *Collect one (1) blue-stopper tube (3.2% sodium citrate), filled to specified volume for APC resistance assay.Do not underfill or overfill.
Also collect one (1) lavender-stopper tube (EDTA) whole blood. Do not centrifuge.

Specimen Management *Hard centrifuge blue stopper tube and separate the plasma within one hour of collection. The specimen MUST be double spun to assure platelet poor plasma. Transport or ship at ambient temperature. If plasma cannot be shipped within one hour of collection, freeze at -70 oC and ship on ice or dry ice.
*If follow-up factor V Leiden mutation test is indicated, the uncentrifuged lavender-stopper tube may be refrigerated up to 72 hours before shipping. Ship overnight at ambient temperature or on wet ice.
Specimen Accepted Daily including weekends. Specimens from outside UAB Hospital will not be sent out to reference laboratories.
Test Performed Factor V Leiden assay performed by reference laboratory. Results available in five days.
Available Stat? No.
Description *If the factor V Leiden mutation assay is ordered without the APC resistance test, the UAB Coagulation Service substitutes the APC resistance test as a screen.
*APC resistance is a thrombotic risk factor caused by the factor V Leiden mutation that is present in 3 to 8% of Caucasians. Factor V Leiden mutation confers a 2 to 8-fold increased risk of venous thrombosis.
Reference Interval Negative. A pathology interpretation accompanies the report.
Critical Value --
Therapeutic Range --
Follow-up Test --
Associated With Venous thrombosis

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