Jeff Hansen

Jeff Hansen

| This email address is being protected from spambots. You need JavaScript enabled to view it.
Human peripheral nerves — all the nerves outside of the central nervous system — are protected by the blood-nerve barrier. Researchers have detailed, for the first time, the normal human transcriptome of the blood-nerve barrier.
In animal experiments, a human-derived glioblastoma significantly regressed when treated with the combination of an experimental enzyme inhibitor and the standard glioblastoma chemotherapy drug, temozolomide.
The AMC21 School of Medicine Research Retreat met on Jan. 19, 2018, with focus on “Strategic Recruitment in the SOM.” As part of the AMC21-five-year goal to reach the top 20 in NIH funding, UAB will need to recruit a net of 80 to 84 funded faculty and retain and develop current faculty.
Large, human cardiac-muscle patches created in the lab have been tested for the first time on large animals in a heart attack model. This clinically relevant approach showed that the patches significantly improved recovery from heart attack injury.
“Human studies suggest DMPA use may raise the risk of HIV infection in exposed women by about 40 percent,” said Zdenek Hel, Ph.D., professor in the UAB Department of Pathology and a co-author of the study. Research indicates alternative contraception methods may reduce the risk in vulnerable populations.
Patients with such mutations potentially need increased disease surveillance and show a high predisposition to develop malignancies.
Daniel Gorelick, Ph.D., assistant professor of pharmacology and toxicology at UAB, has created zebrafish mutants in four different receptors that respond to estrogens. He has used the mutants to help unravel a novel mechanism of estrogen action on heart physiology.
The award honors his distinguished contributions to neuroscience, particularly for discovery of gliotransmission.
This more comprehensive approach may be needed to find ways to delay the progressive heart failure.
Such basic research supports the goal of using stem cells in therapy, where an important hurdle is efficient differentiation.
Page 1 of 14