Connect with NExTNet

Exercise profoundly influences virtually all aspects of human biology; yet major knowledge gaps remain. The National Exercise Clinical Trials Network (NExTNet) was established to facilitate multi-site exercise clinical trials to address these knowledge gaps in a disease-specific or population-specific manner. Currently 74 institutions from coast to coast are members of the growing network. Among NExTNet’s primary functions is to foster standardization of procedures for rigorous multi-site trials. The University of Alabama at Birmingham (UAB) Center for Exercise Medicine serves as the NExTNet Coordinating Center.  


NIH awards aim to understand molecular changes during physical activity.

The National Institutes of Health Common Fund announced December 13, 2016 the first awards for the Molecular Transducers of Physical Activity in Humans Program, which will allow researchers to develop a comprehensive map of the molecular changes that occur in response to physical activity. Nineteen grants will support researchers across the country to collect samples from people of different races, ethnic groups, sex, ages, and fitness levels. The samples will be analyzed to uncover how physical activity changes the chemical molecules within our bodies, which could lead to people engaging in more targeted and optimized types of activity.

Information about the sites, many of which are NExTNet members, is available at


NExTNet teleconferences occur bi-monthly on the second Tuesday at 10am CST. For more information on how to join, email