Xinrui Li, PhD

Xinrui_LiInstructor of Medicine 




Shelby Building, Room 206
1825 University Boulevard

Telephone:(205) 934-3727




BSc (Life Sciences), Fudan University, Shanghai, China, 2003
PhD, (Cell Biology), University of Alabama at Birmingham, 2009
Postdoctoral Fellow, Department of Medicine, Division of Clinical Immunology & Rheumatology, 2012


Research Description

Genetic variations in candidate genes that alter signaling properties/functions in normal immune system, as well as their potential contribution to autoimmune diseases and their underlying mechanism.

Selected Publications


Absher DM, Li X, Waite LL, Gibson A, Roberts K, Edberg J, Chatham WW, Kimberly RP. 2013. Genome-Wide DNA Methylation Analysis of Systemic Lupus Erythematosus Reveals Persistent Hypomethylation of Interferon Genes and Compositional Changes to CD4+ T-cell Populations. PLoS Genet. 2013 Aug;9(8):e1003678. doi: 10.1371/journal.pgen.1003678. Epub 2013 Aug 8. PMID:23950730. Free PMC Article
Kaihong Su, Hengxuan Yang, Xinrui Li, Xiaoli Li, Andrew W. Gibson, John M. Cafardi, Tong Zhou, Jeffrey C. Edberg and Robert P. Kimberly. 2007. Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosus. J Immunol. 178(5):3272-80
Xinrui Li, Kaihong Su, Alexander J. Szalai, Jianming Wu, Yan Zhang, Tong Zhou, Robert P. Kimberly and Jeffrey C. Edberg. 2008. Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion. J Immunol. 181(2):1012-8
Travis S. Ptacek, Xinrui Li, James M. Kelley and Jeffrey C. Edberg. 2009. Copy number vatiants in genetic susceptibility and severity of systemic lupus erythematosus. Cytogenet Genome Res 123:142-147
Xinrui Li, Travis S. Ptacek, Elizabeth E. Brown and Jeffrey C. Edberg. 2009. Fc receptors: structure, function and role as genetic risk factors in SLE. Genes and Immunity. 10: 380-389
Andrew W. Gibson, Xinrui Li, Jianming Wu, Julie G. Baskin, Chander Raman, Jeffrey C. Edberg and Robert P. Kimberly. 2012. Serine phosphorylation of FcRI cytoplasmic domain is required for lipid raft localization and interaction with protein 4.1G. J Leukoc Biol. 91(1):97-103

SOM Epilogue Menu