February 25, 2013

State of the art: Sweatt edits, illustrates neuroscience book
The book addresses molecular, cellular, behavioral and clinical roles for epigenetic mechanisms in the nervous system

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jsweattDavid Sweatt, Ph.D., chair of the Department of Neurobiology in the University of Alabama at Birmingham School of Medicine, is among the editors of the new textbook “Epigenetic Regulation in the Nervous System,” which was published by Academic Press on February 25, 2013. He also illustrated the book with his paintings, which are inspired by epigenetics, the anatomy of nerve cells and the regulation of gene function in the brain.

The book addresses molecular, cellular, behavioral and clinical roles for epigenetic mechanisms in the nervous system. Epigenetic changes are chemical reactions that turn our genes on and off during our lifespan – without changing the DNA code we inherited from our parents. One theory has it that such reactions represent the mechanism by which our neural networks store memories.

“Given the recent rapid pace of discovery in this new scientific sub-discipline, it was time to introduce a foundational book that will be broadly relevant to emerging research programs investigating the role of epigenetics in the nervous system,” said Sweatt. “This book is the first unified synthesis of information on molecular epigenetics, development, cellular physiology and biochemistry, plasticity and behavioral models.” 

The book is primarily intended for advanced undergraduates, graduate students, active researchers and physician-scientists newly interested in the emerging field. Interested parties can buy it at Amazon.com.  Along with Sweatt, the book’s other editors were Michael MeaneyEric Nestler and Schahram Akbarian.

Sweatt is also responsible for the book’s extensive illustrations, which are copies of his paintings depicting the role of epigenetic processes in the brain, and relate to work under way in his lab. As an artist, Sweatt’s paintings reflect a central theme, he said: “the awesome complexity of the nervous system at all levels, from cognition to molecular genetics to everything in between.”
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