Research - News
The clinically approved drug ruxolitinib suppressed a mouse model of melanoma that is resistant to immune checkpoint blockers.
The UAB projects will investigate was to improve and increase the use of artificial intelligence in biomedical research.
Owsley and McGwin will lead three data collection sites in the collection of data to inform machine learning approaches to provide critical insights into the endemic condition Type 2 diabetes mellitus.
The study, an exception from informed consent trial, will compare whole blood to blood components in the treatment of traumatic injuries.
UAB researchers show there is no longer a connection between the previously linked gene and elevated blood pressure in those of African ancestry.
UAB is participating in a multi-center clinical trial that will dig deeper into the connection between hypertension and salt intake.
Noninvasive ventilation is possible in infants at limits of viability. But unlike in slightly older preterm infants, noninvasive ventilation did not show an advantage in infants of 22 weeks-0 days to 23 weeks-6 days gestational age.
Researchers from UAB and other institutions are seeking to better understand the aging differences between males and females.
Carbohydrates are directly linked to the development of Type 2 diabetes, but a higher-carb diet is underused in research models.
The new technique to predict seizure clusters could, if confirmed, have a profound impact on patients with drug-resistant epilepsy who are prone to seizure clusters. 
Persuasion knowledge is triggered by sponsorship disclosures, which may have adverse effects on a brand’s trustworthiness, a UAB study suggests.
Social media has been a useful tool to inform a community about research studies that are exempt from informed consent protocols.
The study seeks to determine whether prothrombin complex concentrate, a blood-clotting agent, could help save the lives of patients at risk for severe bleeding after injury.
Zhang wins $11.2 million NIH PPG grant to improve heart attack recovery through growth of new heart muscle cells.
This is the first study to examine mistreatment from patients across the entire clinical team and to examine the experience of gender and sexual minorities.
The deciphering of a new signaling cascade sheds light on how mutations in metabolism cause normal cells to become cancerous.
Results published in the Journal of Alzheimer’s Disease show patients with one cancer diagnosis were less likely to develop dementia and had an overall slower cognitive decline than patients with no history of cancer.  
A novel activity against hypothiocyanite has been found for an E. coli enzyme and homologs enzymes in Streptococcus, Staphylococcus and Bacteroides species, with implications for diseases like cystic fibrosis and inflammatory bowel disease.
The UAB Center for AIDS Research excels in partnering with local organizations and public health agencies to develop, evaluate and implement interventions to improve HIV prevention, testing, linkage, and adherence to care and treatment.
Emergency department workers were the first line of defense against COVID, but their risk of infection was higher when they were not at work in their hospitals.
The researchers found that ARID1A-deficient bladder cancers are sensitive to combination therapies with the EZH2 inhibitor and inhibitors of PI3K, in a synergistic manner.
These changes, seen in a mouse model, are a likely proteome signature for reductive stress cardiomyopathy. About one in six heart failure patients shows reductive stress, according to a 2018 clinical study.
Women who have never smoked have smaller lung airways than men do, leading to higher risk for COPD.
Since its inception, the network has conducted dozens of studies that either have been completed, are in data collection or are in development.

The first known U.S. study evaluates the mental health of practicing dentists and dental hygienists during the COVID-19 pandemic.
 
This five-year study will determine the effectiveness of CHW-based palliative care programs in improving palliative care outcomes for African American patients with advanced-stage illnesses.
UAB researchers have developed a plasma-enabled process that will limit the spread of toxins that could enter a patient’s bloodstream from implants.
This monoclonal antibody cocktail is deliverable via a nasal dose, and it is also effective against SARS, MERS and several coronavirus cold viruses. The antibodies are engineered for long-acting effectiveness, potentially lasting a year or more when used in humans.
Through this grant, Catledge will explore and develop a class of materials known as high-entropy ceramics.
Gargya Malla, M.D., Ph.D., used the UAB REGARDS study to evaluate the effect of living in a disadvantaged area on heart failure risk. She was awarded second place in a data challenge hosted by the American Heart Association® and the Association of Black Cardiologists.
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