Research - News
This is the first study to examine mistreatment from patients across the entire clinical team and to examine the experience of gender and sexual minorities.
The deciphering of a new signaling cascade sheds light on how mutations in metabolism cause normal cells to become cancerous.
Results published in the Journal of Alzheimer’s Disease show patients with one cancer diagnosis were less likely to develop dementia and had an overall slower cognitive decline than patients with no history of cancer.  
A novel activity against hypothiocyanite has been found for an E. coli enzyme and homologs enzymes in Streptococcus, Staphylococcus and Bacteroides species, with implications for diseases like cystic fibrosis and inflammatory bowel disease.
The UAB Center for AIDS Research excels in partnering with local organizations and public health agencies to develop, evaluate and implement interventions to improve HIV prevention, testing, linkage, and adherence to care and treatment.
Emergency department workers were the first line of defense against COVID, but their risk of infection was higher when they were not at work in their hospitals.
The researchers found that ARID1A-deficient bladder cancers are sensitive to combination therapies with the EZH2 inhibitor and inhibitors of PI3K, in a synergistic manner.
These changes, seen in a mouse model, are a likely proteome signature for reductive stress cardiomyopathy. About one in six heart failure patients shows reductive stress, according to a 2018 clinical study.
Women who have never smoked have smaller lung airways than men do, leading to higher risk for COPD.
Since its inception, the network has conducted dozens of studies that either have been completed, are in data collection or are in development.

The first known U.S. study evaluates the mental health of practicing dentists and dental hygienists during the COVID-19 pandemic.
 
This five-year study will determine the effectiveness of CHW-based palliative care programs in improving palliative care outcomes for African American patients with advanced-stage illnesses.
UAB researchers have developed a plasma-enabled process that will limit the spread of toxins that could enter a patient’s bloodstream from implants.
This monoclonal antibody cocktail is deliverable via a nasal dose, and it is also effective against SARS, MERS and several coronavirus cold viruses. The antibodies are engineered for long-acting effectiveness, potentially lasting a year or more when used in humans.
Through this grant, Catledge will explore and develop a class of materials known as high-entropy ceramics.
Gargya Malla, M.D., Ph.D., used the UAB REGARDS study to evaluate the effect of living in a disadvantaged area on heart failure risk. She was awarded second place in a data challenge hosted by the American Heart Association® and the Association of Black Cardiologists.
The UAB Multidisciplinary Sarcoidosis Clinic is focused on better understanding and treating sarcoidosis, to help patients with serious cases live longer, healthier lives.
UAB experts highlight the social determinants of obesity and add to the growing body of evidence identifying potential solutions to address obesity and related conditions.
Single-nucleus RNA-sequencing in a newborn pig model showed increased cell cycle activity and proliferation in cardiomyocytes, which helped remuscularize the left ventricle after experimental heart attack.
The grant is being used to fund a first-of-its-kind clinical trial that will recruit healthy individuals through a “genome-first” approach and perform deep metabolic phenotyping to understand the underlying mechanisms responsible for the regulation of the human body’s metabolism through natriuretic peptide hormones.
X-ray crystallography revealed the structure of the HIV-1 matrix protein at 2.1 angstroms resolution, advancing understanding of key mechanisms of viral assembly.
The study revealed that, among critically ill patients undergoing tracheal intubation, fluid bolus administration did not significantly decrease the incidence of cardiovascular collapse.
Vacuuming, mopping, walking a pet or playing catch may be enough activity to avoid a stroke, according to a national study published in JAMA Network Online.
Surprisingly, several competing models for this clathrin-mediated endocytosis all appear to function in two cell lines tested.
To facilitate gene-level queries of data from more than 10,000 cancer patient transcriptome sequences and proteomics data from 2,000 patients, researchers have developed a user-friendly cancer data analysis web platform called UALCAN.
This grant is being used to fund the first-of-its-kind and largest clinical study in the United States to perform deep physiological phenotyping and will exclusively recruit Black adults to study the use of FDA-approved medications and their role in improving cardiometabolic health.
New findings published in the Journal of the American Medical Association show an eGFR equation that excludes race as a coefficient and includes creatine and cystatin C measurements could demonstrate racial differences in the risk of kidney failure requiring dialysis.
The investigators will look at diet’s impact on mobility, physical and cognitive function, as well as on pain, fatigue, sleep, mood and anxiety, in people with multiple sclerosis
The biodegradable nanovehicles accumulated in human breast cancer tumors in mice after systemic injection, and they inhibited oncogene expression and extended survival of the mice.
The $20 million National Science Foundation award will help UAB and eight other Alabama-based universities build research infrastructure. UAB’s share will be about $2 million.
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