Landon Shay Wilson

Landon Shay Wilson

Scientist I
University of Alabama at Birmingham
Department of Pharmacology and Toxicology
459 McCallum Bldg.
1918 University Blvd.
Birmingham, AL 35294
Tel: (205) 975-0832
Fax: (205) 934-6944
E-mail :


1996-2000 Auburn University
B.S., Biochemistry


  1. Larson-Casey JL, Vaid M, Gu L, He C, Cai GQ, Ding Q, Davis D, Berryhill TF, Wilson LS, Barnes S, Neighbors JD, Hohl RJ, Zimmerman KA, Yoder BK, Longhini ALF, Hanumanthu VS, Surolia R, Antony VB, Carter AB.
    Increased flux through the mevalonate pathway mediates fibrotic repair without injury. J Clin Invest. 2019 Oct 14. pii: 127959. [doi: 10.1172/JCI127959] [Epub ahead of print] [PMID: 31609245]
  2. Rainey K, Wilson L, Barnes S, Wu H.
    Quantitative Proteomics Uncovers the Interaction between a Virulence Factor and Mutanobactin Synthetases in Streptococcus mutans.
    mSphere. 2019 Sep 25;4(5). pii: e00429-19. [doi: 10.1128/mSphere.00429-19] [PMID: 31554721]
  3. Heaven MR, Wilson L, Barnes S, Brenner M.
    Relative stabilities of wild type and mutant glial fibrillary acidic protein in patients with Alexander disease.
    J Biol Chem. 2019 Sep 4. pii: jbc.RA119.009777. doi: 10.1074/jbc.RA119.009777. [Epub ahead of print] PMID: 31484723
  4. Brad Griesenauer, Tuan M. Tran, Kate R. Fortney, Diane M. Janowicz, Paula Johnson, Hongyu Gao, Stephen Barnes, Landon S. Wilson, Yunlong Liu, Stanley M. Spinola.
    Determination of an Interaction Network between an Extracellular Bacterial Pathogen and the Human Host.
    mBio. [doi: 10.1128/mBio.01193-19]
  5. Chen J, Nichols KK, Wilson L, Barnes S, Nichols JJ.
    Untargeted lipidomic analysis of human tears: A new approach for quantification of O-acyl-omega hydroxy fatty acids.
    Ocul Surf. 2019 Feb 25. pii: S1542-0124(18)30352-5. doi: 10.1016/j.jtos.2019.02.004. [Epub ahead of print] Review. [PMID: 30818035]
  6. White CR, Datta G, Wilson L, Palgunachari MN, Anantharamaiah GM.
    The ApoA-I Mimetic Peptide 4F Protects Apolipoprotein A-I From Oxidative Damage.
    Chem Phys Lipids. 2019 Jan 29. pii: S0009-3084(18)30185-3. [doi: 10.1016/j.chemphyslip.2019.01.009] [Epub ahead of print] [PMID: 30707910]
  7. Lin VY, Fain MD, Jackson PL, Berryhill TF, Wilson LS, Mazur M, Barnes SJ, Blalock JE, Raju SV, Rowe SM.
    Vaporized E-Cigarette Liquids Induce Ion Transport Dysfunction in Airway Epithelia.
    Am J Respir Cell Mol Biol. 2018 Dec 21. [doi: 10.1165/rcmb.2017-0432OC] [Epub ahead of print] [PMID: 30576219]
  8. Chumley P, Zhou J, Mrug S, Chacko BK, Parant JM, Challa AK, Wilson LS, Berryhill TF, Barnes S, Kesterson RA, Bell PD, Darley-Usmar VM, Yoder BK, Mrug M.
    Truncating PKHD1 and PKD2 mutations alter energy metabolism.
    Am J Physiol Renal Physiol. 2018 Dec 19. [doi: 10.1152/ajprenal.00167.2018] [Epub ahead of print] [PMID: 30566001]
  9. Boohaker L, Halloran B, Wilson L, Berryhill T, Barnes S, Griffin R, Askenazi D.
    Absorbent materials to collect urine can affect proteomics and metabolomic biomarker concentrations.
    Clin Chem Lab Med. 2018 Oct 31. pii: /j/cclm.ahead-of-print/cclm-2018-0931/cclm-2018-0931.xml. [doi: 10.1515/cclm-2018-0931] [Epub ahead of print] No abstract available. [ PMID: 30375345]
  10. Panthi S, Chen J, Wilson L, Nichols JJ.
    Detection of Lipid Mediators of Inflammation in the Human Tear Film
    Eye Contact Lens. 2018 Oct 5. [doi: 10.1097/ICL.0000000000000551] [Epub ahead of print] [PMID: 30303825]
  11. Yarar-Fisher C, Kulkarni A, Li J, Farley P, Renfro C, Aslam H, Bosarge P, Wilson L, Barnes S.
    Evaluation of a ketogenic diet for improvement of neurological recovery in individuals with acute spinal cord injury: a pilot, randomized safety and feasibility trial.
    Spinal Cord Ser Cases. 2018 Sep 21;4:88. doi: 10.1038/s41394-018-0121-4. eCollection 2018. [PMID: 30275980]
  12. Lal CV, Kandasamy J, Dolma K, Ramani M, Kumar R, Wilson L, Aghai ZH, Barnes S, Blalock JE, Gaggar A, Bhandari V, Ambalavanan N.
    Early Airway Microbial Metagenomic and Metabolomic Signatures are Associated with Development of Severe Bronchopulmonary Dysplasia.
    Am J Physiol Lung Cell Mol Physiol. 2018 Aug 16. [doi: 10.1152/ajplung.00085.2018] [Epub ahead of print] [PMID: 30113227]
  13. Hough KP, Wilson LS, Trevor JL, Strenkowski JG, Maina N, Kim YI, Spell ML, Wang Y, Chanda D, Dager JR, Sharma NS, Curtiss M, Antony VB, Dransfield MT, Chaplin DD, Steele C, Barnes S, Duncan SR, Prasain JK, Thannickal VJ, Deshane JS.
    Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics.
    Sci Rep. 2018 Jul 9;8(1):10340. [doi: 10.1038/s41598-018-28655-9] [PMID: 29985427]
  14. Kim T, Nason S, Holleman C, Pepin M, Wilson L, Berryhill TF, Wende AR, Steele C, Young ME, Barnes S, Drucker DJ, Finan B, DiMarchi R, Perez-Tilve D, Tschoep M, Habegger KM.
    Glucagon-receptor Signaling Regulates Energy Metabolism Via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21.
    Diabetes. 2018 Jun 20. pii: db171502. [doi: 10.2337/db17-1502] [Epub ahead of print] [PMID: 29925501]
  15. Paul B, Royston KJ, Li Y, Stoll ML, Skibola CF, Wilson LS, Barnes S, Morrow CD, Tollefsbol TO.
    Impact of genistein on the gut microbiome of humanized mice and its role in breast tumor inhibition.
    PLoS One. 2017 Dec 21;12(12):e0189756. [doi: 10.1371/journal.pone.0189756] eCollection 2017. [PMID: 29267377]
  16. Pier B, Edmonds JW, Wilson L, Arabshahi A, Moore R, Bates GW, Prasain JK, Miller MA
    Comprehensive profiling of prostaglandins in human ovarian follicular fluid using mass spectrometry.
    Prostaglandins Other Lipid Mediat. 2017 Nov 9. pii: S1098-8823(17)30098-9. [doi: 10.1016/j.prostaglandins.2017.11.001] [Epub ahead of print] [PMID: 29129796]
  17. Prasain JK, Wilson LS, Arabshahi A, Grubbs C, Barnes S.
    Mass spectrometric evidence for the modification of small molecules in a cobalt-60-irradiated rodent diet.
    J Mass Spectrom. 2017 Aug;52(8):507-516. [doi: 10.1002/jms.3950] Erratum in: J Mass Spectrom. 2017 Oct;52(10 ):707.
    [ PMID: 28544323]
  18. Radka CD, DeLucas LJ, Wilson LS, Lawrenz MB, Perry RD, Aller SG.
    Crystal structure of Yersinia pestis virulence factor YfeA reveals two polyspecific metal-binding sites.
    Acta Crystallogr D Struct Biol. 2017 Jul 1;73(Pt 7):557-572. [doi: 10.1107/S2059798317006349] Epub 2017 Jun 30. [PMID:28695856]
  19. Jordan SJ, Olson KM, Barnes S, Wilson LS, Berryhill TF, Bakshi R, Brown LT, Press CG, Geisler WM.
    Lower Levels of Cervicovaginal Tryptophan are Associated with Natural Clearance of Chlamydia in Women.
    J Infect Dis. 2017 May 17. [Epub ahead of print] [doi: 10.1093/infdis/jix240] [PMID:28520912]
  20. Shamik Das, William P. Jackson, Jeevan K. Prasain, Ann Hanna, Sarah K. Bailey, J. Allan Tucker, Sejong Bae, Landon S. Wilson, Rajeev S. Samant, Stephen Barnes & Lalita A. Shevde
    Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling.
    Scientific Reports 7, Article number: 40773 [doi:10.1038/srep40773]
  21. Raju SV, Lin VY, Liu L, McNicholas CM, Karki S, Sloane PA, Tang L, Jackson PL, Wang W, Wilson L, Macon KJ, Mazur M, Kappes J, DeLucas LJ, Barnes S, Kirk K, Tearney GT, Rowe SM.
    The CFTR Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating CF
    TR Inhibition by Cigarette Smoke.
    Am J Respir Cell Mol Biol. 2016 Sep 1. [Epub ahead of print] [PMID:27585394]
  22. Chacko BK, Wall SB, Kramer PA, Ravi S, Mitchell T, Johnson MS, Wilson L, Barnes S, Landar A, Darley-Usmar VM.
    Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophils.
    Redox Biol. 2016 Jun 23;9:57-66. [doi: 10.1016/j.redox.2016.06.003] [Epub ahead of print] [PMID: 27393890]
  23. Heaven MR, Flint D, Randall SM, Sosunov AA, Wilson L, Barnes S, Goldman JE, Muddiman DC, Brenner M.
    Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease.
    J Proteome Res. 2016 Jul 1;15(7):2265-82. [doi: 10.1021/acs.jproteome.6b00316] Epub 2016 Jun 2. [PMID: 27193225]
  24. Rao S, Walters KB, Wilson L, Chen B, Bolisetty S, Graves D, Barnes S, Agarwal A, Kabarowski JH.
    Early lipid changes in acute kidney injury using SWATH lipidomics coupled with MALDI tissue imaging.
    Am J Physiol Renal Physiol. 2016 Feb 24:ajprenal.00100.2016. doi: 10.1152/ajprenal.00100.2016. [Epub ahead of print] [PMID: 26911846]
  25. Xie X, Wang X, Mick GJ, Kabarowski JH, Shay Wilson L, Barnes S, Walcott GP, Luo X, McCormick K.
    Effect of n-3 and n-6 Polyunsaturated Fatty Acids on Microsomal P450 Steroidogenic Enzyme Activities and In Vitro Cortisol Production in Adrenal Tissue from Male Yorkshire Boars.
    Endocrinology. 2016 Feb 18:en20151831. [Epub ahead of print] [PMID: 26889941]
  26. Jeevan K. Prasain, Landon Wilson, Hieu D. Hoang, Ray Moore and Michael A. Miller
    Comparative Lipidomics of Caenorhabditis elegans Metabolic Disease Models by SWATH Non-Targeted Tandem Mass Spectrometry
    Metabolites 2015, 5(4), 677-696; [doi:10.3390/metabo5040677]
  27. Brossier NM1, Prechtl AM, Longo JF, Barnes S, Wilson LS, Byer SJ, Brosius SN, Carroll SL.
    Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells.
    J Neuropathol Exp Neurol. 2015 Jun;74(6):568-86. [doi: 10.1097/NEN.0000000000000201] [PMID: 25946318]
  28. Harper VM, Oh JY, Stapley R, Marques MB, Wilson L, Barnes S, Sun CW, Townes T, Patel RP.
    Peroxiredoxin-2 Recycling Is Inhibited During Erythrocyte Storage.
    Antioxid Redox Signal. 2015 Feb 1;22(4):294-307. [doi: 10.1089/ars.2014.5950] Epub 2014 Nov 10. [PMID: 25264713]
  29. Wilson L, Arabshahi A, Simons B, Prasain JK, Barnes S.
    Improved high sensitivity analysis of polyphenols and their metabolites by nano-liquid chromatography-mass spectrometry.
    Arch Biochem Biophys. 2014 Oct 1;559:3-11. [doi: 10.1016/] [PMID: 24967696]
  30. Lee S, Henderson MJ, Schiffhauer E, Despanie J, Henry K, Kang PW, Walker D, McClure ML, Wilson L, Sorscher EJ, Zeitlin PL.
    Interference with ubiquitination in CFTR modifies stability of core glycosylated and cell surface pools.
    Mol Cell Biol. 2014 Apr 28. [Epub ahead of print] [PMID: 24777605]
  31. Glinskii OV, Li F, Wilson LS, Barnes S, Rittenhouse-Olson K, Barchi JJ Jr, Pienta KJ, Glinsky VV.
    Endothelial integrin α3β1 stabilizes carbohydrate-mediated tumor/endothelial cell adhesion and induces macromolecular signaling complex formation at the endothelial cell membrane.
    Oncotarget. 2014 Mar 15;5(5):1382-9. [PMID: 24675526] [PMCID: PMC4012737]
  32. Viera L, Radmilovich M, Vargas MR, Dennys CN, Wilson L, Barnes S, Franco MC, Beckman JS, Estévez AG.
    Temporal patterns of tyrosine nitration in embryo heart development.
    Free Radic Biol Med. 2013 Feb;55:101-8. [PMID: 23195686]
  33. Chiquito Crasto, Chandrahas Narne, Mikako Kawai, Landon Wilson and Stephen Barnes
    MRMPath and MRMutation, Facilitating Discovery of Mass Transitions for Proteotypic Peptides in Biological Pathways Using a Bioinformatics Approach
    Advances in Bioinformatics, vol. 2013, Article ID 527295, 10 pages, 2013. [doi: 10.1155/2013/527295]
  34. C. Roger White, Geeta Datta, Amanda K. W. Buck, Manjula Chaddha, Gautam Reddy, Landon Wilson, Mayakonda N. Palgunachari, Mohammad Abbasi and G. M. Anantharamaiah
    Preservation of biological function despite oxidative modifi cation of the apolipoprotein A-I mimetic peptide 4F
    J Lipid Res. Aug;53(8):1576-87 [PMID: 22589558] [doi 10.1194/jlr.M026278]
  35. McClure M, DeLucas LJ, Wilson L, Ray M, Rowe SM, Wu X, Dai Q, Hong JS, Sorscher EJ, Kappes JC, Barnes S.
    Purification of CFTR for mass spectrometry analysis: identification of palmitoylation and other post-translational modifications. Protein Eng Des Sel. 2012 Jan;25(1):7-14. Epub 2011 Nov 25. [PMID: 22119790] [PMCID: PMC3276306]
  36. Buckoreelall K, Wilson L, Parker WB.
    Identification and characterization of two adenosine phosphorylase activities in Mycobacterium smegmatis.
    J Bacteriol. 2011 Aug 5. [Epub ahead of print] [PMID: 21821769] [doi:10.1128/JB.05394-11]
  37. Li F, Glinskii OV, Zhou J, Wilson LS, Barnes S, Anthony DC, Glinsky VV.
    Identification and analysis of signaling networks potentially involved in breast carcinoma metastasis to the brain.
    PLoS One. 2011;6(7):e21977. [PMID: 21779361]
  38. Mirza S, Wilson L, Benjamin WH Jr, Novak J, Barnes S, Hollingshead SK, Briles DE.
    Serine protease PrtA from Streptococcus pneumoniae plays a role in the killing of S. pneumoniae by apolactoferrin.
    Infect Immun. 2011 Mar 21. [Epub ahead of print] PMID:21422179]
  39. Raska M, Takahashi K, Czernekova L, Zachova K, Hall S, Moldoveanu Z, Elliot MC, Wilson L, Brown R, Jancova D, Barnes S, Vrbkova J, Tomana M, Smith PD, Mestecky J, Renfrow MB, Novak J.
    Glycosylation patterns of HIV-1 gp120 depend on the type of expressing cells and affect antibody recognition.
    J Biol Chem. 2010 May 3. [PMID: 20439465]
  40. Patricia L. Jackson, Xin Xu, Landon Wilson, Nathaniel M. Weathington, J.P. Clancy, J.E.Blalock, Amit Gaggar
    Human Neutrophil Elastase-Mediated Cleavage Sites of MMP-9 and TIMP-1: Implications to Cystic Fibrosis Proteolytic Dysfunction
    Molecular Medicine
  41. Smith DL Jr, Nagy TR, Wilson LS, Dong S, Barnes S, Allison DB.
    The Effect of Mannan Oligosaccharide Supplementation on Body Weight Gain and Fat Accrual in C57Bl/6J Mice.
    Obesity. 2009 Oct 1. Epub 2009 Oct 1. [DOI: 10.1038/oby.2009.308] [PMID: 19798073]
  42. Prasain JK, Peng N, Dai Y, Moore R, Arabshahi A, Wilson L, Barnes S, Michael Wyss J, Kim H, Watts RL.
    Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extract.
    Phytomedicine, 16(2-3):233-43, 2009. [PMID: 19095430]
  43. Mafia K, Gupta R, Kirk M, Wilson L, Srivastava OP, Barnes S.
    UV-A-induced structural and functional changes in human lens deamidated alphaB-crystallin.
    Molecular Vision. 2008 14: 234-48, 2008.
  44. Kim, H., Cope, M., Herring, R., Robinson, G., Wilson, L., Page, G.P., Barnes, S.
    2D Difference Gel Electrophoresis of Prepubertal and Pubertal Rat Mammary Gland Proteomes.
    Journal of Proteome Research, 7 (11): 4638-4650, 2008.
  45. Kim H, Eliuk S, Deshane J, Meleth S, Sanderson T, Pinner A, Robinson G, Wilson L, Kirk M, Barnes S.
    2D gel proteomics: an approach to study age-related differences in protein abundance or isoform complexity in biological samples.
    Methods in Molecular Biology 371:349-391, 2007.
  46. Goldstein RF, Niraj A, Sanderson TP, Wilson LS, Rab A, Kim H, Bebok Z, Collawn JF.
    VCP/p97 AAA-ATPase Does not Interact with the Endogenous Wild-Type CFTR.
    Am J Respir Cell Mol Biol. 2007 Feb 1; [Epub ahead of print]
  47. Horn-Ross PL, Barnes S, Lee VS, Collins CN, Reynolds P, Lee MM, Stewart SL, Canchola AJ, Wilson L, Jones K.
    Reliability and validity of an assessment of usual phytoestrogen consumption (United States).
    Cancer Causes and Control, 17:85-93, 2006.
  48. Deshane J, Chaves L, Sarikonda KV, Isbell S, Wilson L, Kirk M, Grubbs C, Barnes S, Meleth S, Kim H.
    Proteomics analysis of rat brain protein modulations by grape seed extract.
    Journal of Agricultural Food Chemistry, 52: 7872-7883, 2004.
  49. Isom AL, Barnes S, Wilson L, Kirk M, Coward L, Darley-Usmar V.
    Modification of Cytochrome c by 4-hydroxy- 2-nonenal: evidence for histidine, lysine, and arginine-aldehyde adducts.
    Journal of American Society of Mass Spectrometry 15: 1136-1147, 2004.
  50. Boersma BJ, D'Alessandro T, Benton MR, Kirk M, Wilson LS, Prasain J, Botting NP, Barnes S, Darley-Usmar VM, Patel RP.
    Neutrophil myeloperoxidase chlorinates and nitrates soy isoflavones and enhances their antioxidant properties.
    Free Radical Biology and Medicine, 35:1417-1430, 2003.
  51. Prasain JK, Patel R, Kirk M, Wilson L, Botting N, Darley-Usmar VM, Barnes S.
    Mass spectrometric methods for the analysis of chlorinated and nitrated isoflavonoids: a novel class of biological metabolites.
    Journal of Mass Spectrometry, 38: 764-771, 2003.
  52. Prasain JK, Jones K, Kirk M, Wilson L, Smith-Johnson M, Weaver C, Barnes S.
    Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry.
    Journal of Agricultural Food Chemistry, 51:4213-4218, 2003.
  53. Sfakianos MK, Wilson L, Sakalian M, Falany CN, Barnes S.
    Conserved residues in the putative catalytic triad of human bile acid Coenzyme A:amino acid N-acyltransferase.
    Journal of Biological Chemistry, 277: 47270-47275, 2002.
  54. Boersma, B., Patel, R., Benton,M., Kirk, M., Wilson, L., Botting, N., Barnes, S., Darley-Usmar,V.
    Chloronation of Soy Isoflavones Enhances Antioxidant Properties.
    April 2001.