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Division of Endocrinology, Diabetes and Metabolism Heersink School of Medicine

Division of Endocrinology, Diabetes and Metabolism

Assistant Professor of Medicine
Division of Endocrinology, Diabetes and Metabolism

Address:
BDB 866
1720 2nd Ave South
Birmingham, AL 35294-0012

Telephone: (205) 934-9856

Education:
Ph.D. in Cell Biology, University of Alabama at Birmingham, 2001

Research Experience:
Post-doctoral Fellow, Department of Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada (2001-2006)
Research Associate, Department of Medicine, University of Alabama at (2007-2011)
Assistant Professor, Department of Medicine, University of Alabama at Birmingham, (2011-present)

Research Interests:

I am interested in all aspects of cellular and molecular mechanisms of growth hormone (GH) action and GH receptor (GHR) signal transduction. Current research is focused on the understanding of: 1) the mechanisms of inducible GHR metalloproteolysis and its role in the regulation of GH sensitivity; 2) crosstalk between the GH and the insulin-like growth factor-1 (IGF-1) signaling pathways.

Selected Publications:

  1. Jie Xu, Yue Zhang, Philip A. Berry, Jing Jiang, Peter E. Lobie, John F. Langenheim, Wen Y. Chen and Stuart J. Frank (2011) Growth Hormone Signaling in Human T47D Breast Cancer Cells: Potential Role for a Growth Hormone Receptor-Prolactin Receptor Complex. Mol. Endocrinol. 25(4):597-610 (Co-First Authorship)
  2. Yujun Gan, Yue Zhang, Douglas J. DiGirolamo, Jing Jiang, Xiangdong Wang, Xuemei Cao, Kurt R. Zinn, David P. Carbone, Thomas L. Clemens, and Stuart J. Frank (2010) Deletion of IGF-I Receptor (IGF-IR) in Primary Osteoblasts Reduces GH-Induced STAT5 Signaling. Mol. Endocrinol. 24(3):644-656
  3. Barish Ozdamar, Rohit Bose, Miriam Barrios-Rodiles, Hong-Rui Wang, Yue Zhang, and Jeffrey L. Wrana (2005) Regulation of the Polarity Protein Par6 by the TGF-beta Receptor Controls Epithelial Cell Plasticity. Science 307: 1603-1609
  4. Yue Zhang, Hong-Rui Wang, and Jeffrey L. Wrana (2004) Smurf1: A Link between Cell Polarity and Ubiquitination. Cell Cycle 3(4): 391-392
  5. Hong-Rui Wang, Yue Zhang, Barish Ozdamar, Abiodun A. Ogunjimi, Evguenia Alexandrova, Gerald H. Thomsen, and Jeffrey L. Wrana (2003) Regulation of Cell Polarity and Protrusion Formation by Targeting RhoA for Degradation. Science 302: 1775-1779 (Co-First Authorship)
  6. Yue Zhang, Ran Guan, Jing Jiang, John J. Kopchick, Roy A. Black, Gerhard Baumann, and Stuart J. Frank (2001) Growth Hormone (GH)-Induced Dimerization Inhibits Phorbol Ester-Stimulated GH Receptor Proteolysis.  J. Biol. Chem. 276: 24565 -24573
  7. Ran Guan, Yue Zhang, Jing Jiang, Catherine A. Baumann, Roy A. Black, Gerhard Baumann, and Stuart J. Frank (2001) Phorbol Ester- and Growth Factor-Induced Growth Hormone (GH) Receptor Proteolysis and Growth Hormone Binding Protein Shedding: Relationship to Growth Hormone Receptor Downregulation.  Endocrinology 142: 1137 -1147
  8. Yue Zhang, Jing Jiang, Roy A. Black, Gerhard Baumann, and Stuart J. Frank  (2000)  TACE is a Growth Hormone Binding Protein (GHBP) Sheddase: The Metalloprotease TACE/ADAM17 is Critical for (PMA-induced) Growth Hormone Receptor Proteolysis and GHBP Generation.  Endocrinology 141: 4342 -4248
  9. Yue Zhang, Jing Jiang, John J. Kopchick, and Stuart J. Frank  (1999)  Disulfide Linkage of Growth Hormone (GH) Receptors (GHR) Reflects GH-induced GHR Dimerization.  J. Biol. Chem.  274: 33072-33084