|Shahid M. Mukhtar|
SHEL 202, 1825 University Blvd. Birmingham, AL 35294-2182
Functional Genomics and Systems Biology
PhD (Genetics), 2005, Max-Planck Institute for Plant Breeding Research, Cologne, Germany
Genomics and Systems Biology are rapidly evolving disciplines of Biology generating an unprecedented amount of information about gene function and organization of the cell. My research focuses on the molecular mechanisms of host-pathogen interactions using genomics and systems level approaches.
Interactions between diverse pathogenic microbes and their hosts are complex and dynamic. Their outcomes depend upon the ability of the microbe to cause disease and the capacity of the host to mount effective defense responses. Microbial virulence proteins, host surface receptors and intracellular molecules form the foundation for communication between pathogen and host. Pathogenic virulence determinants interact with cellular host targets, and modulate host defenses and/or metabolism in a manner conducive to pathogen proliferation and dispersal. On the other hand, host senses microbes via diverse receptors including pattern-recognition receptors and NOD-like receptors. Experimental determination of a host immune protein-protein interaction network comprised of pathogen effectors, their host targets and immune-related proteins would significantly extend our understanding of the molecular mechanisms by which pathogens successfully parasitize the host, and how hosts actively combat them by triggering effective defenses.
To achieve the above listed goals, I employ diverse cutting-edge technologies including high-throughput sequencing, transcriptomics, protein-protein interactions, degradomics, forward and reverse genetics and bioinformatics. My work allows a global understanding of the molecular mechanisms involved in disease resistance and unraveling novel disease resistance signaling pathways to diverse pathogens.
* These authors contributed equally.
3. Klopffleisch K, Phan N, Augustin K*, Booker S*, Botella JR*,4 Carpita NC*, Carr T*, Chen JG*, Cooke TR*, Delgado M*, Escudero V*, Frick-Chen A*, Friedman E*, Hahn MG*, Jiang K*, Jorda L*, Kruppe L*, Liu C*, Lorek J*, McCann MC*, Molina A*, Moriyama EN*, Mukhtar MS*, Mudgil Y*, Pattathil S*, Schwarz J*, Seta S*, Tan M*, Temp U*, Trusov Y*, Urano D*, Welter B*, Yang J*, Panstruga R, Uhrig JF, Jones AM. (2011). The Arabidopsis G protein network: linking G protein signaling, cell wall carbohydrates and plant morphogenesis. Molecular Systems Biology 7:532
* These authors are listed alphabetically.
4. Mukhtar MS*, Carvunis A-R*, Dreze M*, Epple P*, Steinbrenner J, Moore J, Tasan M, Galli M, Hao T, Nishimura MT, Pevzner SJ, Donovan SE, Ghamsari L, Santhanam B, Romero V, Poulin MM, Gebreab F, Gutierrez BJ, Tam S, Monachello D, Boxem M, Harbort CJ, McDonald N, Gai L, Chen H, He Y, EU Effectoromics Consortium, Vandenhaute J, Roth FP, Hill DE, Ecker JR, Vidal M*, Beynon J*, Braun P* and Dangl JL* (2011) Independently evolved virulence effectors converge onto hubs in a plant immune system network. Science, 333: 596-601.
(The article is featured in SCIENCE 333: 532-533, Nature Reviews Genetics 12, 586, on websites of NSF and American Society of Plant Biologists and several other news forums and press releases).