Jeffrey A. Engler, Ph.D.--Regulation of Matrix
Metalloproteinases in Health and Disease Jeffrey A. Engler, Ph.D.--Regulation of Matrix
Metalloproteinases in Health and Disease My laboratory is interested in the mechanism of activation and inhibition of matrix metalloproteinases. These enzymes are important in tissue remodeling, tumor invasion, and inflammatory diseases, such as rheumatoid arthritis and periodontal disease. How these proteolytic enzymes are converted from their latent to active forms is not known but important to understanding the process of extracellular matrix degradation and tissue destruction in many diseases. We have recently obtained evidence that cell signaling pathways may also affect the activation process for matrix metalloproteinases. Our laboratory uses molecular genetics, cell biology, and biochemistry techniques to study this important research question
1982-Present. Professor of Biochemistry and Molecular Genetics
1977-80. Postdoctoral studies at the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
1977. Graduate studies in biochemistry at the University of Wisconsin, Ph.D. in Biochemistry
1971. Undergraduate studies in chemistry at the University of California, Santa Barbara
