We have characterized, purified, and are sequencing clones of a new human monocyte-macrophage receptor that binds triglyceride-rich lipoproteins (chylomicrons and abnormal VLDL) and that has a unique sequence and may be involved in the conversion of these cells into lipid-filled foam cells. As its ligands also affect monocyte-endothelial cell interactions and fibrinolysis, it may be involved in thrombosis as well as atherosclerosis in certain pathologic states.
1992-1993. Chair, Multidisciplinary Committee for Vascular Biology Research Program
1988-Present. Professor of Medicine and Chief of Lipoprotein Metabolism, Div. of Gerontology and Geriatrics, UAB
1987. Visiting Scientist, Donner Laboratory, University of California, Lawrence Berkeley Labs, Berkeley, CA
1987-1988. Associate Professor of Medicine. Div. of Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine
1980-1986. Assistant Professor of Medicine, Division of Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine
1977-80. Instructor, Dept. of Medicine, Baylor College of Medicine