Joanne Murphy-Ullrich, Ph.D.-Extracellular Matrix
Regulation of Cell and Growth Factor Function Joanne Murphy-Ullrich, Ph.D.-Extracellular Matrix
Regulation of Cell and Growth Factor Function Our laboratory studies the role of the matricellular glycoprotein thrombospondin (TSP) and other anti-adhesive matrix proteins in down regulation of cell-matrix interactions occurring through receptor-mediated intracellular signaling events. These anti-adhesive proteins have potential physiological roles in facilitating cell adhesive and shape changes requisite for locomotion during development and in response to injury. Another major focus of the lab is in determining the mechanism of latent TGF-beta activation by TSP and the role that this matrix protein plays in determining bioavailability of this growth factor in various pathophysiologic models.
2000-present. Professor, Department of Pathology, UAB
1995-2000. Associate Professor. Department of Pathology, UAB
1991-1995. Assistant Professor, Department of Pathology, UAB.
1990-1991. Research Assistant Professor, Department of Biochemistry, UAB
1988-1990. Research Instructor, Department of Biochemistry, UAB
1986-1988. Senior Research Associate, Department of Biochemistry, UAB
1983-1986. Post-doctoral fellow, University of Wisconsin
1983. University of Wisconsin, Madison, WI - Ph.D.
1976. Marquette University, Milwaukee, WI - B.S.M.T.
