David G. Pritchard, Ph.D.--Role of Group B Streptococcal Hyaluronidase in Pathogenesis


Research Description:

Group B streptococci (GBS) are the most common cause of sepsis and meningitis in newborns in this country. The organism secretes an unusual hyaluronidase that is capable of degrading hyaluronic acid by a processive mode of action and can also release chondroitin sulfate chains from proteoglycan aggregates. The roles of this enzyme in promoting systemic invasion GBS and contributing to neurological injury in GBS meningitis are being actively studied.


Biography:

1996-Present. Professor, Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham

1993-Present. Professor, Department of Pediatrics, University of Alabama at Birmingham

1992-1996. Professor (School-Wide), School of Medicine, University of Alabama at Birmingham

1985-1992. Research Associate Professor, Department of Microbiology, University of Alabama at Birmingham

1984-1992. Assistant Professor, Department of Pediatrics, University of Alabama at Birmingham

1984-Present. Graduate Faculty, University of Alabama at Birmingham

1981-1985. Research Assistant Professor, Department of Microbiology, University of Alabama at Birmingham

1978-Present. Associate Scientist, Comprehensive Cancer Center, University of Alabama at Birmingham

1976-1981. Research Associate, Department of Microbiology, University of Alabama at Birmingham

1975. Received Ph.D. in Biochemistry at UCLA

1975-1976. Assistant Research Scientist, Department of Immunology, City of Hope National Medical Center, Duarte, CA

1973-1975. Junior Research Scientist, Department of Immunology, City of Hope National Medical Center, Duarte, CA


Recent Publications:


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