Paul W. Sanders, M.D. -- TGF-beta in Health and Disease States

Research Description:

Our laboratory has an interest in the pathogenesis of monoclonal light chain-related glomerulopathy. We have found that certain light chains stimulate mesangial cells in culture to produce TGF-beta, which in turn stimulates production of extracellular matrix proteins. These observations form the basis of the glomerulosclerosis in this disease.

Biography:

1991-Present. Assistant Professor of Physiology and Biophysics (secondary appointment), School of Medicine, UAB

1990-Present. Associate Professor of Medicine, Division of Nephrology, Dept. of Medicine, UAB

1989-Present. Chief, Nephrology Section, Veterans Affairs Medical Center, Birmingham, AL

1982-85. Fellowship, Nephrology Research and Training Center, School of Medicine, University of Alabama at Birmingham

1975-79. University of South Alabama College of Medicine, Mobile, AL - M.D.

1972-75. University of Alabama in Huntsville, Huntsville, AL - B.S. (Chemistry)

Recent Publications:

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