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CCSB Executive Committee

These Executive Committee members , representing four schools and seven departments, provide leadership for the research, cores, and CCSB enrichment activities, ensure communication, linkages, and integration across the core areas; evaluate the progress of the cores; identify funding opportunities; and provide reports to the TIAC

Jere P. Segrest, MD, PhD, Director, CCSB: Research includes interdisciplinary use of computational and experimental biology to: i) determine the structure and dynamics of plasma lipoproteins; ii) determine the structure and dynamics of transmembrane proteins; and iii) using the resulting dynamic structure-function maps, develop therapeutics for disorders, such as atherosclerosis, cystic fibrosis, cancer and Alzheimer’s disease .

Peter Edward Prevelige, Jr. PhD, Professor of Microbiology: Interests include leveraging an interdisciplinary approach, using an array of genetic, biochemical, biophysical, and structural tools, to study assembly of protein subunits into polymeric supramolecular structures, an area of promise therapeutically, for diverse indications such as viral & bacterial infections, Alzheimer’s disease, and neoplasia.

David Graves, PhD, Chair, Department of Chemistry: Research includes NMR studies that provide pivotal insight into molecular structures and geometries of key complexes between proteins and nucleic acids. These type studies have led to generalized structural motifs for the sequence-specific protein-DNA interactions.

Lawrence J. DeLucas, OD, PhD, Director, Center for Biophysical Sciences and Engineering: Research includes protein crystallography, structure-based drug design, and biotechnology. His lab developed a nanocrystallization system that is used to rapidly prepare protein crystallization conditions. They are currently developing in situ diagnostic tools that will allow investigators to rapidly determine the best crystallization conditions for each protein studied.

Anthony Skjellum , PhD, Chair, Department of Computer and Information Sciences : Interests include developing successful computational and informational capabilities and strategies to integrate High Performance Computing, Collaborative Computing, and Computer Graphics and Geometric Modeling in an NIH Roadmap Initiatives consistent environment to help ensure research success at UAB.

Bharat Soni, PhD, Chair, Department of Mechanical Engineering: Interests include application of Enabling Technology Laboratory (ETL) and High-Performance Computing resources to support multidisciplinary aspects of computational simulations and applications through research and development in computer aided geometry design, grid/mesh generation and adaptation, visualization, virtual reality, domain decomposition methods, integrated simulation environments, graphical user interfaces and parallel algorithms.

Mark Walter, PhD, Professor of Microbiology: Research interests include using protein crystallography to define the molecular details of cytokines and the high affinity cytokine-receptor interactions. The three-dimensional models obtained from this work will assist in the production of "designer cytokines" that will have tremendous potential as new pharmaceuticals for treating several types of cancer, arthritis, and AIDS.

Dmitry Vassylyev, PhD, Professor of Biochemistry and Molecular Genetics: Research interest is focused on the studies of the molecular mechanisms of transcription using protein crystallography as a tool and RNA polymerase and its complexes with nucleic acids and transcription factors as a major target.



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