The CSB has unparalleled capacity in the area of collecting x-ray diffraction data and analyzing these coordinates for three dimensional structure determination of proteins and protein drug complexes.
X-Ray Diffraction: This 2,116 square foot facility maintains four fully operational bays for in-house X-ray diffraction experiments. Equipment includes:
- Two rotating anode x-ray generators RUH3R and RU-200
- Three Rigaku R-axis IV 300mm image plate systems each with Osmic multilayer X-ray focusing optics (Blue Optics from Rigaku/MSC)
- Rigaku/MSC X-Stream cryogenic crystal freezing equipment is available for use on each of the image plate systems.
Crystallography Computing: This 646 square foot computing facility provides a central computing network system for data processing, data transfer, structure determination, graphics, and database management in conjunction with all the latest software modeling programs available. Remote access to a UAB 128-Beowulf Intel® processor-based Linux cluster allows “pipeline” approaches to be used to automate and accelerate the structure determination process.
- D*TREK & HKL2000 are available for data processing and full crystallographic program suites like CNS and CCP4i as well as molecular graphic capabilities.
SERCAT: Since 1997, UAB has been a member of the Southeast Regional Collaborative Access Team (SERCAT) and has dedicated access to two of the most powerful beamlines at the Argonne National Laboratory in