The Department of Biomedical Engineering is proud to welcome Manuel Rosa-Garrido, Ph.D., as Assistant Professor.

Rosa-Garrido is from southern Spain where he obtained his two bachelor’s degrees, in biology (from the University of Jaen) and biochemistry (University of Granada). Fascinated by epigenetics, he moved to northern Spain, where he received his Ph.D. in biomedicine from the University of Cantabria (UC). Rosa-Garrido was then recruited to the University of California Los Angeles (UCLA), where he worked as a postdoctoral fellow in Thomas Vondriska's lab and as an Assistant Project Scientist at the David Geffen School of Medicine.

Rosa-Garrido’s interest in cardiac epigenetics focuses on the role that chromatin structure plays in the development of heart failure. This interest stems from the current lack of knowledge of how control of gene expression, mediated by chromatin's spatial organization, participates in driving pathology. His work pioneered the use of high-resolution chromatin conformation capture (Hi-C) to study how chromatin structure is altered during cardiac disease. His research is focused on 1) identifying factors involved in the 3D organization of the cardiac genome and 2) testing the deployment of targeted chromatin structural remodeling as a new therapy to prevent or reverse cardiac pathology.