Kapp, J.A. and Ingraham, J.S. Anti-protein plaque-forming cells
detected with high efficiency by the use of red cells coupled to bovine serum
globulin through Bis-diazo-benzidine. J. Immunol. 104:1039, 1970.
Kapp, J.A. and Benacerraf, B. The rosette cell response of several mouse strains
to immunization with both sheep and pigeon erythrocytes; magnitude of errors caused
by cytophilic antibody. Eur. J. Immunol. 2:467, 1972.
Kapp, J.A., Pierce, C.W., and Benacerraf, B. Genetic control of immune responses
in vitro. I. Development of primary and secondary plaque-forming cell responses
to the random terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by mouse
spleen cells in vitro. J. Exp. Med. 138:1107, 1973.
Kapp, J.A., Pierce, C.W., and Benacerraf, B. Genetic control of immune responses
in vitro. II. Cellular requirements for the development of primary plaque-forming
cell responses to the random terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10
(GAT) by mouse spleen cells in vitro. J. Exp. Med. 138:1121, 1973.
Pierce, C.W., Kapp, J.A., Wood, D.D. and Benacerraf, B. Immune responses in vitro.
X. Functions of macrophages. J. Immunol. 112:1181, 1974.
Benacerraf, B., Katz, D.H., Kapp, J.A., and Pierce, C.W. Regulatory mechanisms
in the immune response. Proceedings of the Society of General Physiologists. In:
Cellular Selection and Regulation on the Immune Response, G.M. Edelman, ed., Raven
Press, New York, p. 265, 1974.
Kapp, J.A., Pierce, C.W., and Benacerraf, B. Genetic control of immune responses
in vitro. III. Tolerogenic properties of the terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10
(GAT) for spleen cells from nonresponder (H-2s and H-2q) mice. J. Exp. Med. 140:172,
1974.
Benacerraf, B., Kapp, J.A., Pierce, C.W., and Katz, D.H. Genetic control of immune
responses in vitro. IV. Conditions for the cooperative interactions between nonresponder
parental B cells and primed (responder x nonresponder)F1 T cells in the development
of an antibody response under Ir gene control in vitro. J. Exp. Med. 140:185,
1974.
Kapp, J.A., Pierce, C.W., Schlossman, S., and Benacerraf, B. Genetic control of
immune responses in vitro. V. Stimulation of suppressor T cells in nonresponder
mice by the terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). J. Exp.
Med. 140:648, 1974.
Benacerraf, B., Kapp, J.A., and Pierce, C.W. Stimulation of specific suppressor
T cells by the terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10 in genetic
nonresponder mice. In: Immunological Tolerance: Mechanism and Potential Therapeutic
Applications, B. Benacerraf and D.H. Katz, eds., Academic Press, Inc., New York,
p. 507, 1975.
Pierce, C.W., Kapp, J.A., Solliday, S., Dorf, M.E., and Benacerraf, B. Immune
responses in vitro. XI. Suppression of primary IgM and IgG plaque-forming cell
responses in vitro by alloantisera against leukocyte alloantigens. J. Exp. Med.
140:921, 1974.
Kapp, J.A., Pierce, C.W., and Benacerraf, B. In vitro studies of the cellular
interactions in an antibody response controlled by an immune response (Ir) gene(s).
In: Immune Recognition, A. Rosenthal, ed., Academic Press, Inc., New York, p.
667, 1975.
Kapp, J.A., Pierce, C.W., and Benacerraf, B. Genetic control of immune responses
in vitro. VI. Experimental conditions for the development of helper T cell activity
specific for the terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) in
nonresponder mice. J. Exp. Med. 142:50, 1975.
Pierce, C.W. and Kapp, J.A. The role of macrophages in antibody responses in vitro.
In: Immunobiology of the Macrophage, D.S. Nelson, ed., Academic Press, New York,
p. 1, 1976.
Kapp, J.A., Pierce, C.W., and Benacerraf, B. Role of suppressor T cells in an
Ir gene controlled immune response. In: Suppressor Cells in Immunity, S.K. Singhal
and N.R. St. C. Sinclair, eds, University of Western Ontario Press, p. 84, 1975.
Benacerraf, B., Kapp, J.A., Debre, P., Pierce, C.W. and DeLaCroix, F. The stimulation
of specific suppressor T cells in genetic nonresponder mice by linear random copolymers
of L-amino acids. Transplantation Reviews 26:21, 1975.
Pierce, C.W. and Kapp, J.A. Regulation of immune responses by suppressor T cells.
Contemporary Topics in Immunobiology V, p. 91, 1976.
Debre, P., Kapp, J.A., and Benacerraf B. Genetic control of specific immune suppression.
I. Experimental conditions for the stimulation of suppressor cells by the copolymer
L-glutamic acid50-L-tyrosine50 (GT) in nonresponder BALB/c mice. J. Exp. Med.
142:1436, 1975.
Debre, P., Kapp, J.A., Dorf, M.E., and Benacerraf, B. Genetic control of specific
immune suppression. II. H-2-linked dominant genetic control of immune suppression
by the random copolymer L-glutamic acid50-L tyrosine50 (GT). J. Exp. Med. 142:1447,
1975.
Kapp, J.A., Pierce, C.W., DeLaCroix, F., and Benacerraf, B. Immunosuppressive
factor(s) extracted from lymphoid cells of nonresponder mice primed with L-glutamic
acid60-L-alanine30-L-tyrosine10 (GAT). I. Activity and antigenic specificity.
J. Immunol. 116:305, 1976.
Kapp, J.A., Pierce, C.W., and Benacerraf, B. Suppressive activity of lymphoid
cell extracts from nonresponder mice injected with the terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10
(GAT). In: The Role of Products of the Histocompatibility Gene Complex in Immune
Responses, D.H. Katz and B. Benacerraf, eds, Academic press, Inc., New York, p.
569, 1976.
Pierce, C.W., Kapp, J.A., and Benacerraf, B. Stimulation of antibody responses
in vitro by antigen-bearing syngeneic and allogeneic macrophages in The Role of
Products of the Histocompatibility Gene Complex in the Immune Responses, D.H.
Katz and B. Benacerraf, eds., Academic Press, Inc., New York, p. 391, 1976.
Pierce, C.W., Kapp, J.A., and Benacerraf. B. Regulation by the H-2 gene complex
of macrophage-lymphoid cell interactions in secondary antibody responses in vitro.
J. Exp. Med. 144:371, 1976.
Pierce, C.W, Kapp, J.A., and Benacerraf, B. Genetic restriction of macrophage-lymphocyte
interactions in secondary antibody responses in vitro. In: Cold Spring Harbor
Symposium on Quantitative Biology, vol XLI, Origins of Lymphocyte Diversity, Laboratory
of Quantitative Biology, Cold Spring Harbor, Long Island, New York, pp. 563-570,
1977.
Kapp, J.A., Pierce, C.W., and Benacerraf, B. Immunosuppressive factor(s) extracted
from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10
(GAT). II. Cellular source and effect on responder and nonresponder mice. J. Exp.
Med. 145:828, 1977.
Theze, J., Kapp, J.A., and Benacerraf, B. Immunosuppressive factor(s) extracted
from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10
(GAT). III. Immunochemical properties of the GAT-specific suppressive factor.
J. Exp. Med. 145:839, 1977.
Waltenbaugh, C., Theze, J., Kapp, J.A., and Benacerraf, B. Immunosuppressive factor(s)
specific for L-glutamic acid50-L-tyrosine50 (GT). III. Generation of suppressor
T cells by a suppressive extract derived from GT-primed lymphoid cells. J. Exp.
Med. 146:970, 1977.
Pierce, C.W. and Kapp, J.A. Functions of macrophages in antibody responses in
vitro. In: American Association of Immunologists and Reticuloendothelial Society
Symposium, Macrophage Functions in Immunity, Fed. Proc. 37:86, 1977.
Pierce, C.W., Germain, R.N., Kapp, J.A., and Benacerraf, B. Secondary antibody
responses in vitro to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by (responder
x nonresponder)F1 spleen cells stimulated by parental GAT-M?. J. Exp. Med. 146:1827,
1977.
Benacerraf, B., Waltenbaugh, C., Theze, J., Kapp, J.A., and Dorf, M. The I region
genes in genetic regulation. ICN-UCLA Symposium on Molecular and Cellular Biology,
Vol. VI, pp. 363-382, 1977.
Kapp, J.A., Pierce, C.W., Theze, J., and Benacerraf, B. Expression of Ir genes
in T cells. In: Ir Genes and Ia Antigens, H.O. McDevitt, ed., Academic Press,
New York, p. 529, 1978.
Pierce, C.W. and Kapp, J.A. H-2 gene complex regulation of macrophage lymphocyte
interactions in antibody responses in vitro in Ir Genes and Ia Antigens, H.O.
McDevitt, ed., Academic Press, New York, p. 357, 1978.
Theze, J., Kapp, J.A., and Benacerraf, B. Properties of the purified immunosuppressive
factors specific for L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). In: Ir
Genes and Ia Antigens, H.O. McDevitt, ed., Academic Press, New York, p. 539, 1978.
Kapp, J.A., Pierce, C.W., Theze, J., and Benacerraf, B. Modulation of immune responses
by suppressor T cells. In: American Association of Immunologists Symposium, Autologous
Immune Reactions as Regulatory Mechanisms, Fed. Proc. 37:2361, 1978.
Germain, R.N., Theze, J., Kapp, J.A., and Benacerraf, B. Antigen specific T cell
mediated suppression. I. Induction of L-glutamic acid60-L-alanine30-L-tyrosine10
(GAT) specific suppressor T cells in vitro requires both antigen specific T suppressor
factor (TsF) and antigen. J. Exp. Med. 147:123, 1978.
Kapp, J.A. Immunosuppressive factors from lymphoid cells of nonresponder mice
primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). IV. Lack of strain
restrictions among allogeneic nonresponder donors and recipients. J. Exp. Med.
147:997, 1978.
Pierce, C.W. and Kapp, J.A. L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT).
A probe for regulatory mechanisms in antibody responses. In: Immunobiology of
Proteins and Peptides I, M.Z. Stavitsky and A.B. Stavitsky, eds., Plenum Press,
New York, pp. 419-428, 1978.
Kapp, J.A. and Strayer, D.S. H-2-linked Ir gene control of antibody responses
to porcine insulin. I. Development of insulin-specific antibodies in some but
not all nonresponder strains injected with proinsulin. J. Immunol. 121:978, 1978.
Pierce, C.W. and Kapp, J.A. Antigen-specific suppressor T cell activity in genetically
restricted immune spleen cells. J. Exp. Med. 148:1271, 1978.
Pierce, C.W. and Kapp, J.A. Suppressor T cell activity in responder x nonresponder
(C57BL/10 x DBA/1)F1 spleen cells responsive to L-glutamic acid60-L-alanine30-L-tyrosine10
(GAT). J. Exp. Med. 148:1282, 1978.
Pierce, C.W., Tadakuma, T., and Kapp, J.A. Role of nonspecific and specific suppressor
factors in immunity. Annals of the New York Academy of Sciences 332:336, 1979.
Kapp, J.A., Strayer, D.S., Robbins, P.F., and Perlmutter, R.M. Insulin-specific
murine antibodies of limited heterogeneity. I. Genetic control of spectrotypes.
J. Immunol. 123:109, 1979.
Kapp, J.A. and Araneo, B.A. Interactions of macrophages and T cells in the development
of antibody and proliferative responses. In: The Regulatory Role of Mononuclear
Phagocytes in Immunity, A.S. Rosenthal and E. Unanue, eds., Academic Press, Inc.,
New York, p. 141, 1980.
Pierce, C.W. and Kapp, J.A. Nonspecific and specific suppressor factors in The
Lymphokines, John W. Hadden and William E. Stewart, eds., The Humana Press, Inc.,
New Jersey, pp. 207-230, 1981.
Araneo, B.A. and Kapp, J.A. H-2-linked Ir gene control of T cell proliferative
responses to the synthetic terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10
(GAT). I. Requirements for T cell activation in responder and nonresponder mice.
J. Immunol. 124:1492, 1980.
Pierce, C.W. and Kapp, J.A. Regulatory T cell subsets: Functions in responses
to an antigen under Ir gene control. In: Regulatory T Lymphocytes, B. Pernis and
H.J. Vogel, eds., Academic Press, Inc. New York, p. 301-314, 1980.
Araneo, B.A. and Kapp, J.A. Immunosuppressive factor(s) from lymphoid cells of
nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT).
V. Inhibition of T cell proliferative responses. J. Immunol. 125:118, 1980.
Kapp, J.A., Araneo, B.A., and Clevinger, B.L. Suppression of antibody and T cell
proliferative responses to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by
a specific monoclonal T cell factor. J. Exp. Med. 152:235, 1980.
Pierce, C.W., and Kapp, J.A. Activities of nonspecific and specific suppressor
T-cell factors in immune responses in Trends in Inflammation Research, G.P. Velo,
ed., Birkhauser Verlag, Boston, p. 126, 1979.
Bucy, R.P. and Kapp, J.A. Ir gene control of the immune response to insulin. I.
Pork insulin stimulates T cell activity in nonresponder mice. J. Immunol. 126:603,
1981.
Kapp, J.A. and Bucy, R.P. Ir gene control of insulin-specific immune response
in mice. In: Basic and Clinical Aspects of Immunity to Insulin, A. Rosenthal,
K. Keck and P. Erb, eds., Walter de Gruyter, Berlin. pp. 71-80. 1981.
Thomas, J.S., Kapp, J.A., Schroer, J.A. and Rosenthal, A.S. Influence of insulin
modification upon the immune response to insulin. In: Basic and Clinical Aspects
of Immunity to Insulin, K. Keck and P. Erb, eds., Walter de Gruyter, Berlin. pp.
81-91, 1981.
Kapp, J.A. and Araneo, B. A. Production and characterization of T cell hybrids
producing antigen-specific suppressor factors. In: Monoclonal Antibodies and T
Cell Hybridomas. G. J. Hammerling, U. Hammerling, and J. F. Kearney, eds., Elsevier
Publishing Co. PP. 509-515, 1981.
Kapp, J.A., Araneo, B. A., Ju, S-T., and Dorf, M. E. Immunogenetics of Monoclonal
Suppressor T Cell Products. In: Immunoglobulin Idiotypes and Their Expression.
C. Janeway, E. Sercarz, and H. Wigzell, eds., Academic Press, NY, pp. 387-396,
1981.
Webb, D.R., Krupen, K., Araneo, B.A., Kapp, J.A., Nowowiejski, I., Healy, C.,
Weider, K., and Stein, S. Chemical characterization of antigen-specific suppressor
lymphokines. In: Progress in Cancer Research and Therapy 20:187-194, 1981.
Kapp, J.A. and Araneo, B.A. Structure and function of monoclonal antigen-specific
suppressor T cell factors. Lymphokines, Vol. 5, Marc Feldmann, editor. Academic
Press, Inc. New York. pp. 187-195, 1982.
Araneo, B.A. and Kapp, J.A. Genetic analysis of immune suppression. I. Gene complementation
is required for suppression of antigen-specific proliferative responses by T cell
derived factors. Immunogenetics 14:221-230, 1981.
Kapp, J.A. and Araneo, B.A. Characterization of antigen-specific suppressor factors
from T cell hybridomas. In: Isolation, Characterization and Utilization of T Lymphocyte
Clones. C. Garrison Fathman and Frank Fitch, editors. Academic Press, pp. 139-148,
1982.
Krupen, K., Araneo, B.A., Brink, L., Kapp, J.A., Stein, S., Wieder, K.J., and
Webb, D.R. Purification of a monoclonal T cell suppressor factor specific for
L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). Proc. Natl. Acad. Sci (USA)
79:1254-1258, 1982.
Kapp, J.A. and Araneo, B.A. Antigen-specific suppressor T cell interactions. I.
Induction of an MHC-restricted suppressor factor specific for L-glutamic acid50-L-tyrosine50.
J. Immunol. 128:2447-2452, 1982.
Webb, D.R., Araneo, B.A., Healy, C., Kapp, J.A., Krupen, K., Nowowiejski, I.,
Pierce, C.W., Sorensen, C.M., Stein, S., and Weider, K.J. Purification and biochemical
analysis of antigen-specific suppressor factors isolated from T-cell hybridomas.
Current Topics in Microbiology and Immunology 100:53-59, 1982.
Weider, K., Araneo, B.A., Kapp, J.A., and Webb, D.R. Cell-free translation of
a biologically active, antigen-specific suppressor T cell factor. Proc. Natl.
Acad. Sci. (USA) 79:3599-3603, 1982.
Thomas, J.W., Bucy, R.P. and Kapp, J.A. T cell independent responses to an Ir
gene controlled antigen. I. Characteristics of the immune response to insulin
complexed to Brucella abortus. J. Immunol. 129:6-10, 1982.
Strayer, D.S. and J.A. Kapp. Insulin-specific antibodies and insulitis in mice
immunized with purified porcine insulin. Clin. Exp. Immunol. 47:77-84, 1982.
Trial, J., J.A. Kapp, C.W. Pierce, D.C. Shreffler, C.M. Sorensen and C. Waltenbaugh.
Expression of cell surface antigens by suppressor T cell hybridomas. I. Comparison
of phenotype and function. J. Immunol. 130:565, 1983.
Bucy, R.P. and J.A. Kapp. Ir gene control of immune responses to insulins. II.
Phenotypic differences in T cell activity among nonresponder strains of mice.
J. Immunol. 130:2062, 1983 .
Healy, C.T., J.A. Kapp, S. Stein, L. Brink and D.R. Webb. Comparative analysis
of a monoclonal antigen-specific T suppressor factor obtained from supernatant,
membrane or cytosol of a T-cell hybridoma. In: Ir Genes: Past, Present and Future.
C.W. Pierce, S.E. Cullen, J.A. Kapp, B.D. Schwartz, D.C. Shreffler, editors. Humana
Press, Inc. 1983, pp. 565-568.
Webb, D.R., Araneo, B.A., Gerassi, E., Healy, C., Kapp, J.A., Krupen, K., Nowowiejski,
I., Pierce, C.W., Sorensen, C.M., Stein, S. and Wieder, K.J. Purification and
analysis of antigen-specific suppressor proteins derived from T-cell hybridomas.
J. Hadden, et al, editors. Adv. Immunopharmacology 2:765; Pergamon Press, NY,
1983.
Kapp, J.A., C.W. Pierce, S.E. Cullen, D.C. Shreffler, and B.D. Schwartz. Ir Genes:
New Tests of Familiar Arguments. Immunology Today 4 (no.1):1, 1983.
Webb, D.R., J.A. Kapp, C.W. Pierce. The biochemistry of antigen-specific T cell
factors. Annual Rev. Immunology. 1:423-438, 1983.
Kapp, J.A., B.A. Araneo, C.M. Sorensen and C.W. Pierce. Identification of H-2
restricted suppressor T cell factors specific for L-glutamic acid50-L-tyrosine50
(GT) and L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). In: Ir Genes: Past,
Present and Future. C.W. Pierce, S.E. Cullen, J.A. Kapp, B.D. Schwartz, D.C. Shreffler,
editors. Humana Press, Inc., 1983. pp. 553-563.
Pierce, C.W. and J.A. Kapp. Antigen-specific suppressor T cells as one mode of
expression of immune response genes. In: Ir Genes: past, present and future. C.W.
Pierce, S.E. Cullen, J.A. Kapp, B.D. Schwartz, D.C. Shreffler, editors., Humana
Press, Inc. 1983. pp. 317-325.
Hauptfeld, V., M. Hauptfeld, M. Nahm, J. Trial, J.A. Kapp and
D. Shreffler. Partial characterization of 8 anti-I-J and 3 anti-Ia monoclonal
reagents. In: Ir Genes: Past, Present and Future. C.W. Pierce, S.E. Cullen,
J.A. Kapp, B.D. Schwartz and D.C. Shreffler, editors. Humana Press, Inc. 1983.
pp. 51-55.
Robbins, P.F., J.W. Thomas, P.E. Jensen, and J.A. Kapp. Insulin-specific tolerance
induction. I. Abrogation of helper T cell activity is controlled by H-2 linked
Ir genes. J. Immunol. 132:43-49, 1984.
Kraig, E., M. Kronenberg, J.A. Kapp, C.W. Pierce, A.F. Abruzzini, C.M. Sorensen,
L.E. Samelson, R.H. Schwartz and L.E. Hood. GAT-specific T and B cells do not
transcribe similar heavy chain variable region gene segments. J. Exp. Med. 158:192-209,
1983.
Kronenberg, M., E. Kraig, G. Siu, J.A. Kapp, J. Kappler, P. Marrack, C.W. Pierce
and L. Hood. Three T-cell hybridomas do not contain detectable heavy chain variable
gene transcripts. J. Exp. Med. 158:210-227, 1983.
Kapp, J.A., C.M. Sorensen, C.W. Pierce, J. Trial, D.C. Shreffler and D.R. Webb.
Characterization of hybridomas producing single and two chain antigen-specific
suppressor T cell factors. In: T cell Hybridoma, M. J. Taussig, Ed. CRC Press,
1985, pp. 111-121.
Webb, D.R., E. Gerassi, C.T. Healy, J.A. Kapp, K. Krupen, C.W. Pierce, and C.M.
Sorensen. Biochemical characterization of monoclonal T cell suppressor factors
specific for the antigen L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). Lymphokine
Research 2:103, 1983.
Webb, D.R., J.A. Kapp, and C.W. Pierce. Biochemical and genetic analysis of antigen-specific
suppressor factors obtained from T cell hybrids. In: T cell Hybridomas, M. J.
Taussig, Ed. CRC Press, 1985, pp. 187-195.
Kronenberg, M., M. Steinmetz, J. Kobori, E.Kraig, J.A. Kapp, C.W. Pierce, C.M.
Sorensen, G. Suzuki, T. Tada, and L. Hood. RNA transcripts for I-J polypeptides
are apparently not encoded between the I-A and I-E subregions of the murine major
histocompatibility complex. Proc. Natl. Acad. Sci. (USA). 80:5704-5708, 1983.
Kapp, J.A., C.M. Sorensen and C.W. Pierce. Antigen-specific suppressor T cell
interactions. II. Characterization of two different types of suppressor T cell
factors for L-glutamic acid50-L-tyrosine50 (GT) and L-glutamic acid60-L-alanine30-L-tyrosine10
(GAT). J. Exp. Med. 158:1962, 1983.
Healy, C.T., J.A. Kapp and D.R. Webb. Purification and biochemical analysis of
antigen-specific suppressor factors obtained from the supernatant, membrane or
cytosol of a T cell hybridoma. J. Immunol. 131:2843, 1983.
Kapp, J.A., C.M. Sorensen, and C.W. Pierce. 1984. Comparison of two different
types of antigen-specific suppressor T cell factors. Progress in Immunology V,
871.
Kapp, J.A., C.M. Sorensen, C.W. Pierce. Production and characterization of antigen-specific
suppressor factors from hybridoma cell lines. Methods in Enzymology, 116:303,
1985.
Webb, D.R., J.A. Kapp and C.W. Pierce. Antigen-specific suppressor factors: An
overview. Methods in Enzymology, 116:295, 1985.
Jensen, P.E. and J.A. Kapp. Regulatory mechanisms of the immune response to heterologous
insulins. I. Development and regulation of plaque-forming cell responses in vitro.
Cell. Immunol. 87:73-84, 1984.
Pierce, C.W., J.A. Kapp, C.M. Sorensen and J. Trial. T cell subsets in (responder
X nonresponder)F1 mice regulating antibody responses to L-glutamic acid60-L-alanine30-L-tyrosine10
(GAT). J. Immunol., 133: 2874, 1984.
Kapp, J.A., P.E. Jensen, P.F. Robbins and C. Fritschle. Insulin-specific tolerance
induction. II. Tolerant helper T cells can be rescued by insulin complexed to
Brucella abortus. J. Immunol., 133: 2888, 1984.
Jensen, P.E., C.W. Pierce and J.A. Kapp. Regulatory mechanisms in immune responses
to heterologous insulins. II. Suppressor T cell activation associated with nonresponsiveness
in H-2b mice. J. Exp. Med., 160: 1012, 1984.
Pierce, C.W., C.M. Sorensen and J.A. Kapp. T cell subsets regulating antibody
responses to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) in virgin and immunized
nonresponder mice. J. Immunol., 134: 29, 1985.
Kapp, J.A., C.W. Pierce and C.M. Sorensen. Antigen-specific T-cell suppressor
factors. Hospital Practice. 19: 85, 1984.
Hedrick, S.M., R.N. Germain, M.J. Bevan, M. Dorf, I. Engel, P. Finke, N. Gascoigne,
E Heber-Katz, J.A. Kapp, Y. Kaufmann, J. Kaye, F. Melchers, C. Pierce, R.H.
Schwartz, C. Sorensen, M. Taniguchi, and M. Davis. Rearrangement and transcription
of a T cell receptor Beta chain gene in different T cell subsets. Proc.Nat.Acad.Sci.(USA)
82: 531, 1984.
Jensen, P.E. and J.A. Kapp. Stimulation of helper T cells and dominant suppressor
T cells that recognize autologous insulin. J. Mol. Cell. Immunol. 2:133, 1985.
Krupen, K., C. Turck, S. Stein, J.A. Kapp and D.R. Webb. GAT specific suppressor
factors. Methods in Enzymology, 116:325, 1985.
Hauptfeld , V., J.A. Kapp, K. Frederick, J.A. Trial and D.S. Schreffler. Monoclonal
antibodies to mouse antigens. II. Characterization of thirty-one anti-I-J reagents.
Immunogenetics 21:193, 1985.
Jensen, P.E. and J.A. Kapp. Genetics of insulin-specific helper and suppressor
T cells in nonresponder mice. J. Immunol. 135:2990, 1985.
Lopez, M.T., C.M. Sorensen, J.A. Kapp and C.W. Pierce. Cellular interactions of
L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) specific suppressor factors.
I. Inhibition of the activity of GAT-specific helper T cell clones by monoclonal
GAT-specific suppressor T cell factors. J. Immunol. 136:798, 1986.
Trial, J., D.C. Schreffler and J.A. Kapp. Lymphokines regulate expression of cell
surface antigens by murine suppressor T cell hybridomas. Lymphokine Res. 5:275,
1986.
Pierce, C.W., M.T. Lopez, C.M. Sorensen and J.A. Kapp. Cellular requirements and
mechanisms of action of antigen-specific suppressor T cell factors. In: Advances
in Immunopharmacology 3. L. Chedid, J.W. Hadden, F. Spreafico, P. Dukor and D.
Willoughby. Pergamon Press, Ltd., Oxford, GB, 1986, pp. 251-256.
Turck, C., J.A. Kapp and D.R. Webb. Purification and partial
characterization of a monoclonal "second order" suppressor factor
specific for L-glutamic acid60-L-alanine30-L-tyrosine10. J. Immunol., 135:3232,
1985.
Lake, J.P., J.A. Kapp and C. W. Pierce. Regulation of immune responses by T cell
subsets. Role of helper and suppressor T cells in the development and expression
of MHC-restricted antibody responses to L-glutamic acid60-L-alanine30-L-tyrosine10
(GAT) by (responder x responder)F1 spleen cells. J. Immunol. 136:1201, 1986.
Hansen, T.H., W.D. Walsh, R.J. Rubocki and J.A. Kapp. Responses of B6.C-H-2bm12
to heterologous insulins show no correlation with the putative gene conversion
but define Iabm12 as functionally unique. J. Mol. Cell. Immunol. 2:359, 1986.
Pierce, C.W., J.A. Kapp, P.E. Jensen, J.P. Lake, M.T. Lopez, R. Poon, and C.M.
Sorensen. Regulatory T cell subsets, In: Mediators of Immune Regulation and Immunotherapy,
S.K. Singhal and T.L. Delovitch, eds. Elsevier, New York, NY 1986, pp. 58-64.
Poon, R., C.M. Sorensen, C. W. Pierce and J.A. Kapp. Characterization of two monoclonal,
idiotype-binding suppressor T cell factors specific for the antibody response
to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). J. Immunol. 137:3709, 1986.
Lake, J.P., J.A. Kapp and C.W Pierce. Genetic restrictions in the development
of antibody responses to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by nude
mice implanted with semiallogenic thymus glands. J. Immunol., 136:805, 1986.
Webb, D., J.A. Kapp, K. Krupen, C.W. Pierce, C.M. Sorensen, C.W. Turck. Factors
from suppressor T cells: Current status and perspectives. In: Advances in Immunopharmacology,
Vol. 3, eds. L. Chedid, J.W. Hadden, F. Spreafico, P. Dukor and D. Willoughby.
Pergamon Press, Ltd., Oxford, GB, 1986, pp. 149-152.
Turck, C.W., J.A. Kapp and D.R. Webb. Structural analysis of a monoclonal heterodimeric
suppressor factor specific for L-glutamic acid60-L-alanine30-L-tyrosine10. J.
Immunol. 137:1904, 1986.
Jensen, P.E. and J.A. Kapp. Insulin-specific suppressor T cell factors. J. Immunol.
136:1309, 1986.
Kulczycki, A., J. Trial, J.M. Connolly, S. Sharp and J.A. Kapp. Structure and
expression of Fcc receptors on mouse suppressor T cell hybridomas. J. Immunol.
137:2325, 1986.
Jensen, P.E., P.J. Whiteley, J.A. Kapp. Regulatory T cells control the murine
antibody response to insulin. In: The Immunology of Diabetes Mellitus, M. A. Jaworski,
et al., eds. Elsevier Science Publishers, 1986. pp.223-230.
Jensen, P.E., and J.A. Kapp. Bystander help in primary immune responses in vivo.
J. Exp. Med. 164:841, 1986.
Whiteley, P.J., P.E. Jensen, C.W. Pierce, A.F. Abruzzini and J.A. Kapp. Helper
T cell clones that recognize autologous insulin are stimulated in nonresponder
H-2b mice by pork insulin. Proc. Natl. Acad. Sci. USA 85:2723, 1988.
Webb, D.R., C. Turck, K. Krupen, J.A. Kapp, C.M. Sorensen, and C.W. Pierce. Purification
and biochemical analysis of monoclonal, antigen-specific T-cell suppressor factors.
In: Cellular and Molecular Biology of Lymphokines, C. Sorg, A. Schimpl, eds. Academic
Press, NY, 1985, p. 69-73.
Spinella, D.G., T.H. Hansen, W.D. Walsh, M.A. Behlke, J.P. Tillinghast, A.S. Chou,
P.J. Whiteley, J.A. Kapp, C.W. Pierce, E.M. Shevach,and D.Y. Loh. Receptor diversity
of insulin-specific murine T-cell lines. J. Immunol. 138:3991-3995, 1987.
Webb, D.R., J.A. Kapp, K. Krupen, Pierce, C.W., C.M. Sorensen and C.W. Turck.
Antigen Specific Suppressor Factors. In: Mediators of Immune Regulation and Immunotherapy,
eds. S.K. Singhal and T.L. Delovitch. Elsevier, New York, NY 1986, pp. 65-69.
Krupen, K.I., J.A. Kapp, C. J. Bellone, G. Jendrisak, and D.R. Webb. Direct demonstration
that an antigen-specific suppressor factor purified from extracts of T cell hybridomas
binds antigen and bears I-J determinants. Lymphokine Research: 7:429-444, 1988.
Kapp, J.A., and C.W . Pierce. Antigen Specific Immune Regulation. In: Human Immunogenetics.
Stephen D. Litwin, ed. Marcel Dekker, Inc., New York, 1989. p. 163-179.
Jensen, P.E., J.A. Kapp and C.W. Pierce. The role of suppressor T cells in the
expression of immune response gene function. J. Mol. Cell. Immunol. 3:267, 1987.
Kapp, J.A., C.M. Sorensen, C.W. Pierce and D.R. Webb. Characterization of GAT-specific
suppressor factors and comparison to other antigen-specific factors. In: Molecular
Basis of Lymphokine Action, D.R. Webb, C.W. Pierce, and S. Cohen, eds. The Humana
Press, Inc., NJ, 1987. pp. 33.
Zimecki, M., and J.A. Kapp. Identification of the antigen-binding molecule on
helper T cell lines specific for L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT).
Archivum Immunologiae et Therapiae Experimentalis 35:361-370, 1987.
Lake, J.P., J.A. Kapp, and C.W. Pierce. Characterization of GAT-Specific Suppressor
T cells in Responder Mice Restricted by Igh-C-linked Genes. J. Immunol. 140:3296,
1988.
Kapp, J.A. and T. Tada. Antigen Binding T Cell Factors. In: The T Cell Receptor,
UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 73, J. Kappler
and M. Davis, eds., Alan R. Liss, Inc., New York, 1988, pp. 263.
Pierce, C.W., C.M. Sorensen and J.A. Kapp. Identification of suppressor T cells
in virgin nonresponder spleen cells responsible for primary unresponsiveness to
L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). J. Immunol. 141:64, 1988.
Sorensen, C.M.. J.A. Kapp and C.W. Pierce. Ir gene control of help and suppression.
Monographs in Allergy 24:227-235, 1988.
Zimecki, M., A.F. Abruzzini, C.W. Pierce, and J.A. Kapp. Antigen presentation
to T cell lines and clones by peritoneal macrophages and peritoneal B cells and
antigen-specific B cell hybridomas. Archivum Immunologiae et Therapeiae Experimentalis
36:409-422, 1988.
Whiteley, P.J., R. Selden and J.A. Kapp. Regulation of self-tolerance to insulin.
Annals of the New York Acad. Sci. 546:238, 1988.
van der Veen, R.C., J.L. Trotter, H.B. Clark, and J.A. Kapp. The adoptive transfer
of chronic relapsing experimental allergic encephalomyelitis with lymph node cells
sensitized to myelin proteolipid protein. J. Neuroimmunol. 21:183, 1989.
Kapp, J.A. and P.J. Whiteley. Insulin determinant recognition by helper and suppressor
T cells. Sercarz, E. (ed.): Antigenic Determinants and Immune Regulation. Chem.
Immunol. Basel, Karger, 1989. 46: 85-100.
Freire-Moar, J., J.A. Kapp and D.R. Webb. Effect of IL-2 on suppressor factor
production. Lymphokine Res. 8:9, 1989.
Whiteley, P.J., J.P. Lake, R.F. Selden, and J.A. Kapp. Tolerance induced by physiological
levels of secreted proteins in transgenic mice expressing human insulin. J. Clin.
Invest. 84:1550-1554, 1989
Devens, B.H., C.M. Sorensen, J.A. Kapp, Pierce, C.W. and D.R. Webb. Indirect evidence
of the nature of the antigen receptor on antigen-specific suppressor cells: Monoclonal
antibodies against GAT-specific suppressor factors can alter the capacity of H-2
specific suppressor cells to regulate the response of CTL to allogeneic target
cells. Annals of the New York Acad. Sci. 546:204, 1988.
Zimecki, M., J.A. Kapp and C.W. Pierce. Establishment of antigen-specific and
MHC-restricted B cell hybridoma clones: a model for studying antigen presentation
to T cell lines and clones. Archivum Immunologiae et Therapiae Experimentalis
36: 395, 1988.
Zimecki, M., Z. Wieczorek, C.W. Pierce, and J.A. Kapp. A comparison of the Conventional
and the Rosette Method of Determination of Interleukin 1 (IL-1) Activity. The
Advantages of the Rosette Method. Archivum Immunologiae Et Therapiae Expermentalis,
36:655, 1988.
Zimecki, M., Z. Wieczorek, J.A. Kapp, and C.W. Pierce. Secretion of Interleukin
1 (IL-1) by Peritoneal Macrophages Upon Contact With Syngeneic T Cells is IA-Restricted
and Antigen-Independent Process. Archivum Immunologiae et Therapiae Experimentalis,
36:661, 1988.
Zimecki, M., Z. Wieczorek, J.A. Kapp and C.W. Pierce. Structures on T cells and
macrophages involved in interleukin 1 (IL-1) secretion by macrophages upon contact
with syngeneic thymocytes. Arch. Immunol. et Therap. Experiment. 37:587-592, 1989.
Whiteley, P. J., and J.A. Kapp. Tolerance in transgenic mice to a non-MHC self-protein
is not a result of clonal deletion. Progress in Immunology 7: 826, 1989.
Kapp, J.A. and C.W. Pierce. Antigen-specific immune regulation. Immunol. Ser.
43:163-179, 1989.
Webb DR, Devens BH, Kraig E, Kapp JA, Pierce CW, Sorensen CM More speculation
on specific suppression (Letter:comment). Immunol. Today, 10: 326, 1989
van der Veen, R.C., J.L. Trotter, W.F. Hickey and J.A. Kapp. The development and
characterization of encephalitogenic cloned T cells specific for myelin proteolipid
protein. Journal of Neuroimmunology. 26:139-145, 1990
Whiteley, P.J., N.J. Poindexter, C.Landon and J.A. Kapp. A peripheral mechanism
preserves self-tolerance to a secreted protein in transgenic mice. J. Immunol.
1445:1376, 1990.
Kraig, E., C.C. Kannapell, K.A. Zborowski, C.W. Pierce and J.A. Kapp. Sequence
of the TCR b chain gene used by a T cell clone specific for the synthetic polymer,
GAT. Nucleic Acids Research 18:5881, 1990 .
Devens, B.H., A.W. Koontz, J.A. Kapp, C.W. Pierce, D.R. Webb. Involvement of two
distinct regulatory T cell populations in the antigen-specific suppression of
cytolytic T cell generation. J. Immunol. 146:1394-1401, 1991.
Zimecki, M., Z. Wieczorek, C.W. Pierce, J.A. Kapp, W. H. Schnaper, and David R.
Webb. Control of Interleukin 1 (IL-1) Activity. I. Inhibition of IL-1 Activity
by Soluble Immune Response Suppressor (SIRS) in vitro. Arch. Immunol. et Therap.
Experiment. 39:213-226, 1991.
Poindexter, N.J., C. Landon, P.J. Whiteley, and J.A. Kapp. Comparison of the T
cell receptors on insulin specific hybridomas from insulin transgenic and nontransgenic
mice. Loss of a subpopulation of self-reactive clones. J.Immunol. 149:38-44, 1992.
van der Veen, R.C., J.L. Trotter, and J.A. Kapp. Immune processing of proteolipid
protein by subsets of antigen-presenting spleen cells. J. Neuroimmunol. 38:139-146,
1992.
J.A. Kapp, Self-tolerance in the Immune System. Panhandle Health 3:21-22, 1992.
van der Veen, R.C., J.A. Kapp, and J.L. Trotter. Fine-specificity differences
in the rcognition of an encephalitogenic peptide by T helper 1 and 2 cells. J.
Neuroimmunol. 48:221-226, 1993.
Zimecki, M., and J.A. Kapp. Presentation of antigen by B cell subsets. I. Lyb-5+
and Lyb-5- B cells differ in ability to stimulate antigen specific T cells. Arch.
Immunol. et Therap. Experiment. 42(2):115-123, 1994.
Zimecki, M., Z. Wieczorek, and J.A. Kapp. Thymocyte-macrophage interactions. Interleukin
6 produced by activated thymocytes induces interleukin I production by macrophages.
Arch. Immunol. et Therap. Experiment. 42:163-169, 1994.
Zimecki, M. and J.A. Kapp. Presentation of antigen by B cell subsets. II. The
role of CD5 B cells in the presentation of antigen to antigen specific T cells.
Arch. Immunol. et Therap. Experiment. 42:349-354, 1994.
Zimecki, M. and J.A. Kapp. Presentation of antigen by B cell subsets. III. Effects
of interleukins on antigen presenting function and phenotype of immature B cells.
Arch. Immunol. et Therap. Experiment. 42:355-360, 1994.
Zimecki, M. and J.A. Kapp. Presentation of antigen by B cell subsets. IV. Defective
T-B cell signaling causes inability to present antigen by B cells from immunodeficient
mice. Arch. Immunol. et Therap. Experiment. 42:361-368, 1994.
Li, Y., Y. Ke, and J.A. Kapp. Delivery of exogenous proteins to the MHC class
I pathway by electroporation. J. Leuk. Biol. 56:616-624 1994.
Ke,Y., R.L. Hunter, and J.A. Kapp. Induction of humoral and
cell mediated immune responses to ovalbumin in TiterMax™ and a new co-polymer
adjuvant. Vaccine Res. 4:1-17, 1995.
Ke, Y., Y. Li, and J.A. Kapp. Ovalbumin injected with complete Freund's adjuvant
stimulates cytolytic responses. Eur. J. Immunol. 25:549-553, 1995.
Li, Q., Y. Ke, J.A. Kapp, N. Fertig, T.A. Medsger Jr., H.C. Joshi. A novel cell-cycle-dependent
350-kDa nuclear protein: C-terminal domain sufficient for nuclear localization.
Biochem. Biophys. Res. Comm. 212:220-228, 1995.
Dombrowski, K.E., Y. Ke, L.F. Thompson, J.A. Kapp. Antigen recognition by cytotoxic
T-lymphocytes is dependent upon ectoATPase activity. J. Immunol. 154:6227-6237,
1995.
Kapp, J.A., C.W. Pierce, and D.R. Webb, B. Devens, E. Engleman, S Fukuse, W Godfrey,
J.P. Lake, J.I. Magnani, P.K. Pradip, A. Sehon. Characterization of the epitope
recognized by a monoclonal antibody that reacts differentially with murine suppressor
T cells. Int. Immunol. 8:1319-1330, 1995.
Zimecki, M., J. Mazurier, G. Spik, and J.A. Kapp. Human lactoferrin induces phenotypic
and functional changes in mouse splenic B cells. Immunol. 86:122-127, 1995
Zimecki, M. and J.A. Kapp. Presentation of antigen by B cell subsets. V. Effects
of interleukin 7 (IL-7) and IL-10 on phenotype and antigen presenting fuction
of immature B cells. Arch. Immunol. et Therap. Experiment. 43:253-257, 1995.
Zimecki, M., J.A. Kapp, and Z. Wieczorek. CD4+ T cells from mice primed for humoral
immunity to sheep erythrocytes (SRBC) specifically inhibit cell-mediated immunity
and vice versa. Arch. Immunol. et Therap. Experiment. 43:259-264, 1995.
Ke, Y. and J.A. Kapp. Oral antigen inhibits priming of CTL, CD4+ T cells and antibody
responses while activating CD8+ suppressor T cells. J. Immunol. 156:916-921, 1996.
Zimecki, M., J. Mazurier, G. Spik, and J.A. Kapp. Lactoferrin inhibits proliferative
response and cytokine production of Th1 but not Th2 cell lines. Arch. Immunol.
Et. Therap. Experiment. 44:259-264, 1996
Weber, C.J., M.K. Hagler, J.T. Chryssochoos, C.P.Larsen, T.C. Pearson, P.E. Jensen,
J.A. Kapp, P.S. Linsely. CTLA4Ig prolongs survival of microencapsulated rabbit
islet xenografts in spontaneously diabetic NOD mice. Transplant. Proceed. 28:821-823,
1996
Ke, Y. and J.A. Kapp. Exogenous antigen gains access to the MHC class I processing
pathway in B cells by receptor-mediated uptake. J. Exp. Med. 184:1179, 1996.
Ke, Y., K. Pearce, J. P. Lake, K. Ziegler, and J.A. Kapp. Gamma
delta T lymphocytes regulate the induction and maintenance of oral tolerance.
J. Immunol. 158:3610-3618, 1997.
Ke, Y., C.L. McGraw, R.L. Hunter and J.A. Kapp. Nonionic triblock copolymers facilitate
delivery of exogenous proteins into the MHC class I and II pathways. Cell. Immunol.
176:113-121, 1997.
Dombrowski, K.E., K.A. Brewer, J.R. Maleckar, T.L. Kirley, J.W. Thomas and J.A.
Kapp. Identification and partial characterization of ectoATPase
expressed by immortalized B lymphocytes. Arch. Biochem. & Biophys. 340:10-18,
1997.
Dombrowski, K.E., Y. Ke and J.A. Kapp. Role of ectoATPase in lymphocyte function.
In: EctoATPases, Plesner, L., Kirley, T.L. and Knowles, A.F., editors. Plenum
Press, New York, NY., 1997, pp. 197-207.
Weber, C.J., M.K. Hagler, J.T. Chryssochoos, J.A. Kapp, G.S. Korbutt, R.V. Rajotte,
P.S. Linsley. CTLA4-Ig prolongs survival of microencapsulated neonatal porcine
islet xenografts in diabetic NOD mice. Cell Transplant. 6:505-508, 1997.
Ke, Y., H. Ma, and J.A. Kapp. Antigen is required for activation of effector activities,
whereas interleukin 2 is required for the maintenance of memory in ovalbumin-specific,
CD8+ cytotoxic T lymphocytes. J. Exp. Med. 187:49-57, 1998.
Ye, K., Y. Ke, N. Keshava, J. Shanks, J.A. Kapp, R.R. Tekmal, J. Petros, and H.C.
Joshi. Opium alkaloid noscapine is an anti-tumor agent that arrests metaphase
and induces apoptosis in dividing cells. Proc. Nat. Acad. Sci. 95:1601-1606, 1998.
Dombrowski, K.E., Y. Ke, K.A. Brewer, and J.A. Kapp. Ecto-ATPase: an activation
marker necessary for effector cell functions. Immunol. Rev.161:111-118, 1998.
Kapp, J.A., and Y. Ke. The role of gamma delta TCR Bearing T
cells in oral tolerance. Res. Immunol. 148:561-567, 1998.
Long, S.A., M. Zimecki, and J.A. Kapp. Bovine and porcine or human insulin activate
distinct CD4+ T cell subsets in C57BL/6 mice. Cell. Immunol. 195:66-74, 1999.
Weber, C.J., J.A. Kapp, M.K. Hagler, S. Safley, J.T. Chryssochoos,
E.L. Chaikof. Long-term survival of poly-L-lysine-alginate microencapsulated
islet xenografts in spontaneously diabetic NOD mice. In: Handbook of Cell and
Encapsulation Technology and Therapeutics. W.M. Kòhtreiber, R.P. Lanza
and W.L. Chick, Eds. Pp 117-137, 1999.
Weber, C.J., S. Safley, M. Hagler, and J.A. Kapp. Evaluation
of Graft-Host Response for Various Tissue Sources and Animal Models. Ann.New
York Acad.Sci. 875: 233-54, 1999.
Ma, H., Y. Ke, Q. Li, and J.A. Kapp. Bovine and human insulin activate CD8+ auto-reactive
CTL expressing both type 1 and type 2 cytokines in C57BL/6 mice. J. Immunol. 164:
86-92, 2000.
Dombrowski, K.E., Y. Ke, H.P. Langston, and J.A. Kapp. The hydrolysis of extracellular
ATP provides essential signals for the effector functions of activated and immortalized
lymphocytes. In: Ecto-ATPases and Related Ectonucleotidases: Proceedings of the
Second International Workshop on Ecto-ATPases and related Ectonucleotidases. Luc
Vanduffel and Raf Lemmens, Eds. Shaker Publishing B.V. Maastricht, The Netherlands,
pp 145-157, 2000.
Ke, Y., K. Ye, H.E. Grossniklaus, D.R. Archer, H.C. Joshi, and J.A. Kapp. Noscapine
inhibits tumor growth with little toxicity to normal tissues or inhibition of
immune responses. Cancer Immunol Immunother 49: 217-225, 2000.
Ma, H. and J.A. Kapp. Antigenic epitopes regulate the phenotype of CD8+ CTL primed
by exogenous antigens. J. Immunol. 164:5698-5703, 2000.
Deshpande, S.P., S. Lee, M. Zheng, B. Song, D. Knipe, J.A. Kapp, and B. T. Rouse.
Herpetic stromal keratitis: a possible autoimmune lesion but no involvement of
molecular mimicry. J. Virol. 75(7): 3077-3088, 2001.
Xu, Y. and J.A. Kapp. Gamma delta T cells are critical for the induction of anterior
chamber-associated immune deviation. Immunol. 104:142-148, 2001.
Ma, H. and J.A. Kapp. Peptide affinity for MHC influences the phenotype of CD8+
T cells primed in vivo. Cell. Immunol. 204:89-96, 2001.
Safley, S.A., J.A. Kapp, and C.J. Weber. Proliferative and
cytokine responses in CTLA4-Ig-treated diabetic NOD mice transplanted with
microencapsulated neonatal porcine ICCs. Cell Transplant. 11:695-705, 2002.
PMID: 12518896
Xu, Y. and J.A. Kapp. Gamma delta T cells in anterior chamber-induced
tolerance in CD8+ CTL. Invest. Opthalmol. Vis. Sci. 43:3473-3479, 2002. PMID:
12407158
McKenna, K.C., Y. Xu, and J.A. Kapp. Injection of soluble
antigen into the anterior chamber of the eye induces expansion and functional
unresponsiveness of antigen-specific CD8+ T cells. J. Immunol. 169:5630-5637,
2002. PMID: 12421942
Langston, H.P., Y. Ke, H. J. Wajchman, K.E. Dombrowski, and J.A. Kapp.
Secretion of IL-2 and IFN?, but not IL-4, by antigen-specific T cells requires
extra-cellular ATP. J. Immunol. 170: 2962-2970, 2003. PMID: 1266548
Ke, Y., L.M. Kapp, and J.A. Kapp. Inhibition of tumor rejection
by gamma delta T cells and IL-10. Cell. Immunol. 221:107-114, 2003. PMID: 12747951
Sanjay G., A. Oran, J. Wajchman, S. Sasaki, C. A. Maris, J.A. Kapp,
and J. Jacob. Genetic tagging shows increased frequency and longevity of antigen-presenting,
skin-derived dendritic cells in vivo. Nat. Immunol. 4:907-912, 2003. PMID:
12910266
Zimring, J.C., S.B. Levery, B. Kniep, L.M. Kapp, M. Fuller, and J.A.
Kapp. CD75s
is a marker of murine CD8+ suppressor T cells. Int. Immunol. 15:1389-1399,
2003. PMID: 14565937
Rong, R., H. Huang, E. Nagata, D. Kalman, J.A. Kapp, J. Tu,
P.F. Worley, S.H. Snyder, and K. Ye. PIKE-L/Homer complex couples mGLuR1 to
PI 3-kinase, preventing neuronal apopotosis. Nat Neurosci. 11:1153-61, 2003
PMID: 14528310
Kapp, J.A., L.M. Kapp, K.C. McKenna, and J.P. Lake. Gamma
delta T cell lines and clones from intraepithelial lymphocytes of the small
intestine inhibit development of CTL responses ex vivo. Immunology 111:155-164,
2004. PMID: 15027900
Kapp, J.A., L. M. Kapp, K.C. McKenna. Gamma delta T Cells
Play an Essential Role in Several Forms of Tolerance. Immunol. Res. 29(1-3):93-102,
2004. PMID: 15181273
Zimring, J.C. and J.A. Kapp. Identification and characterization
of CD8+ suppressor T cells. Immunol. Res. 29(1-3):303-12, 2004. PMID: 15181291
McKenna, Kyle C. and J.A. Kapp. Ocular Immune Privilege and
CTL tolerance. Immunol. Res. 29(1-3):103-12, 2004. PMID: 15181274
Honjo, K, X-Y. Xu, J. A. Kapp, and R. Pat Bucy. Evidence for
cooperativity in the rejection of cardiac grafts mediated by CD4+ TCR Tg T cells
specific for a defined allopeptide. Am. J. Transplant. 4:1762-1768,2004. PMID:
15476474
Honjo, K., X-Y. Xu, J.A. Kapp, and R.P. Bucy. Activation
and migration of allo-peptide specific TCR transgenic T cells in cardiac allograft
rejection. Cell. Immunol. 230:44-55, 2004. PMID: 15541718
S.A. Safley, L.M. Kapp, C. Tucker-Burden, B. Hering, J.A. Kapp,
and C.J. Weber. Inhibition of cellular immune responses to encapsulated
porcine islet xenografts by simultaneous blockade of two different costimulatory
pathways. Transplant. 79: 409-418, 2005. PMID: 15729166
Wen, J. B., K.C., McKenna, C. Barron, H.P. Langston and J.A. Kapp. Use
of superparamagnetic microbeads in tracking subretinal injections. Molecular
Vision 11:256-262, 2005. PMID: 15851980
McKenna, K.C., K.M. Anderson, and J.A. Kapp. CD8+ T
cell tolerance induced by delivery of antigen to the anterior chamber is not
the result of de facto intravenous or mucosal administration of antigen. Ocular
Immunol. Inflam. 13:149-157, 2005. PMID: 16019674
Zimring, J. C., L. M. Kapp, M. Yamada, J. Weiss, and J.
A. Kapp. Regulation of CD8+ cytolytic T lymphocyte differentiation
by a cholinergic pathway. J. Neuroimmunol. 164:66-75, 2005. PMID: 15913791
McKenna, Kyle C. and J.A. Kapp. Accumulation of immunosuppressive
CD11b+ myeloid cells correlates with the failure to prevent tumor growth in
the anterior chamber of the eye. J. Immunol. 177:1599-1608, 2006. PMID:
16849468
Kapp, J.A., A. Cozier, K. Honjo, L.M. Kapp., X.Y. Xu, and R.
Pat Bucy. TCR Transgenic CD8+ T cells activated in the presence of TGFb1
express FoxP3 and mediate linked-suppression of primary immune responses and
cardiac allograft rejection. Int. Immunol. 18:1549-1562, 2006. PMID:
16966495