

The National Eye Institute of the National Institutes of Health has recently announced the renewal of the African Descent and Glaucoma Evaluation Study (ADAGES). Dr. Christopher Girkin, Professor of Ophthalmology and Director of the UAB Glaucoma Service, is the Principal Investigator of the ADAGES clinical center at UAB, one of three national centers for the study. NEI will provide approximately $1 million over two years to UAB Ophthalmology in order to follow participants in the study. ADAGES is the first prospectively designed multi-center, longitudinal study to follow a well-characterized cohort of glaucoma patients of African Descent on a variety of measures of visual function, optic nerve structure, risk assessment, and clinical results. The study’s purpose is to identify what factors account for the differences in glaucoma onset and rate of progression found between individuals of African descent and those of European descent and to determine whether accounting for these differences can be used to optimize algorithms for detection of glaucoma and monitoring progression. Glaucoma is five times more likely to occur in persons of African descent than in those of European descent and is the leading cause of blindness in persons of African descent.
In addition to NEI support, the EyeSight Foundation was critical in supporting the study by providing a “bridge” grant while the project was going through the competitive renewal process at NEI.