Clinton D. Lothrop, Jr., Ph.D. D.V.M. Professor, Department of Biochemistry and Molecular Genetics Areas of Focus:  Hematopoietic stem cell regulation in canine cyclic hematopoiesis , gene therapy of blood diseases in canine models of hemophilia and pyruvate kinase deficiency and nonmyeloablative bone marrow transplantation  for treatment of blood diseases and tolerance induction. Publications

RESEARCH DESCRIPTION

      The focus of research in his laboratory has been hematopoietic stem cell regulation in canine cyclic hematopoiesis , gene therapy of blood diseases in canine models of hemophilia and pyruvate kinase deficiency and nonmyeloablative bone marrow transplantation  for treatment of blood diseases and tolerance induction. The canine models in Dr Lothrop’s laboratory have been invaluable in the preclinical evaluation of  safety, efficacy  and scale up of  novel bone marrow transplantation and gene therapy approaches to treatment of RBC diseases and hemophilia before progressing to human clinical trials. His research is supported by R01 and R24 awards from the NHLBI.

BIOGRAPHY

      Dr. Lothrop is a Professor in the Department of Biochemistry and Molecular Genetics.  He received his B.A. degree from the University of Tennessee in Knoxville, TN in 1977. He also received his Ph.D. degree from the University of Tennessee in 1981 in the study of RNA Catabolism in Cultured Cells. Postdoctoral training was completed in 1983 in Pharmacology and Diagnostic Endocrinology, at University of Tennessee. Dr. Lothrop went on to receive his D.V.M. from the University of Tennessee, as well.  He joined the faculty as a Professor at UAB in 2007.