My research group and I are interested in understanding the structure function relationships of bacterial proteins and enzymes that are responsible for microbial pathogenecity and macromolecules of the host that are required for activating the human complement system in response to invading microorganisms.
Surface proteins and proteinaceous filaments are used by gram-positive bacteria to colonize or invade human tissues. Structural view of these adhesive proteins and protein complexes at the atomic level and knowledge about their assembly and anchoring will enable us to invent strategies to prevent their attachment and thus block infection.
The human complement system contributes to host defense against bacterial infections directly by its opsonic, inflammatory and lytic activities and indirectly enhancing antibody responses. Various deceases are linked to defective, deficient and inappropriately activated complement and we are interested in visualizing the protein molecules essential for complement activation and regulation.
My name is Narayana VL Sthanam, however, if you want to search for my research and publications on Internet, please look for Narayana SV. I am funded by National Institute of Health for doing research at Center for Biophysical Sciences and Engineering in Structural Biology. My hobbies are gardening and table tennis.