About the image: Cilia on ependymal cells in the brain beat to push cerebral spinal fluid through the ventricles of the brain. Defects in cilia function in the Tg737 mutant mice impair this fluid movement as observed by with fluorescently tagged bead and ultimately cause hydrocephalus.

Faculty & Research

Faculty in the CMDB theme are affiliated with multiple departments across UAB. The scientific interests of the faculty are very diverse and interdisciplinary in nature and encompass cell, molecular, and developmental biology using modern tools and approaches as well as a wide range of model organisms and cell culture systems. The research conducted by CMDB faculty addresses fundamental cellular and molecular questions that provide the basis for understanding and treating human disease and developmental abnormalities. Specific research activities of the CMDB faculty can be viewed by visiting individual faculty research and profile pages or by looking under the faculty research focus areas. CMDB faculty research is supported by awards from various agencies, with the majority coming from the National Institutes of Health.

Birth Defects & Development l Disease Mechanisms l Fundamental Cellular Mechanisms


Anupam Agarwal, M.D. - Medicine
Regulation of heme oxygenase gene expression in kidney and vascular injury
Disease Mechanisms  Fundamental Cellular Mechanisms

Jonas Almeida, PhD - Pathology

Informatics; personalized medicine; systems biology; mathematical modeling
Birth Defects & Development  Disease Mechanisms  Fundamental Cellular Mechanisms

Namasivayam Ambalavanan, M.D. - Pediatrics
Neonatal lung development; mechanisms underlying neonatal pulmonary vascular remodeling and neonatal pulmonary hypertension

G. M. Anantharamaiah, Ph.D. - Medicine
Apolipoproteins; amphipathic helices; atherosclerosis
Disease Mechanisms  Fundamental Cellular Mechanisms

Shannon M. Bailey, Ph.D. - Environmental Health Sciences
Molecular mechanisms of chronic alcohol and obesity induced fatty liver disease

Daniel Balkovetz - Medicine
Epithelial cell biology; epithelial cell signal regulation; regulation of paracellular transport across epithelial cell
Disease Mechanisms  Fundamental Cellular Mechanisms

Scott Ballinger, Ph.D. - Molecular and Cellular Pathology
Environmental cardiology; free radical biology; mitochondrial function
Disease Mechanisms  Fundamental Cellular Mechanisms 

Marcas Bamman, Ph.D. - Physiology & Biophysics
Cell/matrix interactions in disease and tissue regeneration

Zsuzsanna Bebok, M.D. - Cell Biology
Membrane protein biogenesis in epithelial cells (CFTR as model); unfolded protein response

David Bedwell, Ph.D. - Microbiology
Mechanism of translation termination; therapies to suppress stop mutations

Susan Bellis, Ph.D. - Physiology & Biophysics
The role of integrin receptors in human biology and disease

Etty Benveniste, Ph.D. - Cell Biology
Immune/nervous system interactions
The CFTR chloride channel control of epithelial sodium channel under physiological and pathological conditions
Disease Mechanisms  Fundamental Cellular Mechanisms

Mark Bevensee, Ph.D. - Physiology & Biophysics
Cellular and molecular physiology of acid-base transporters and pH regulation
Disease Mechanisms  Fundamental Cellular Mechanisms

Mary-Ann Bjornsti, Ph.D. - Pediatrics

J. Edwin Blalock, Ph.D. - Physiology & Biophysics
Rational drug and vaccine design/Neutrophilic Inflammation

Karl-Heinz Braunewell, Ph.D. - Biochemistry/SRI
Molecular and cellular neurobiology; function of neuronal calcium sensors in health and disease
Disease Mechanisms  Fundamental Cellular Mechanisms

Michael Brenner, Ph.D. - Neurobiology
Molecular studies of astrocytes in health and disease
Disease Mechanisms  Fundamental Cellular Mechanisms

William Britt, M.D. - Pediatrics
Human herpesviruses, molecular virology and pathogenesis

Peter Burrows, Ph.D. - Microbiology
Lymphocyte development and function
Disease Mechanisms  Fundamental Cellular Mechanisms

Steven Carroll, M.D., Ph.D. - Pathology
The Role of Neuregulin-1 in Peripheral Nervous System Neoplasia

Chenbei Chang, Ph.D. - Cell Biology
Signaling transduction in development and diseases
Birth Defects & Development   Fundamental Cellular Mechanisms

John C. Chatham, D.Phil. - Pathology
Cardiomyocyte function and metabolism in diabetes and ischemic heart disease 

Ching-Yi Chen, Ph.D. - Biochemistry & Molecular Genetics
Mechanism and regulation of mammalian mRNA turnover

Yabing Chen, Ph.D. - Pathology
Gene regulation in the pathogenesis of cardiovascular diseases, osteoporosis, and cancer

Igor Chesnokov, Ph.D. - Biochemistry & Molecular Genetics
DNA replication and cell cycle in eukaryotes

Louise Chow, Ph.D. - Biochemistry & Molecular Genetics
Human papillomavirus DNA replication and pathogenesis

Sarah Clinton, Ph.D. - Psychiatry & Behavioral Neurobiology
Neurodevelopmental and environmental factors that underlie susceptibility to anxiety and depression

James Collawn, Ph.D. - Cell Biology
Cystic fibrosis; endocytosis; protein trafficking

Rita Cowell, Ph.D. - Psychiatry & Behavioral Neurobiology
Transcriptional regulation of early postnatal brain development: Insights into the pathology of autism and schizophrenia

Judy Creighton, Ph.D. - Anesthesiology
AMPK activates calcium signaling necessary for endothelial barrier repair

Lawrence DeLucas, O.D., Ph.D. - Optometry
Protein crystallography/protein crystal growth

Patrizia DeSarno, Ph.D. - Psychiatry & Behavioral Neurobiology

Jessy Deshane, Ph.D. - Medicine
Inflammatory diseases of the airway

Qiang Ding, Ph.D. - Medicine
Molecular mechanisms of organ fibrosis

Lynn Dobrunz, Ph.D. - Neurobiology
Synaptic transmission and plasticity in hippocampus

Alan Eberhardt, Ph.D. - Biomedical Engineering
Orthopedic and injury biomechanics, using both experimental and computational approaches

Charles Falany, Ph.D. - Pharmacology & Toxicology
Biochemical and physiological properties of human cytosolic sulfotransferases

Michelle Fanucchi, Ph.D. - Environmental Health Sciences
Pulmonary cell biology and toxicology; cell-to-cell interactions in the developing lung as well as in repair after lung injury and disease in children; the role of biochemical defense mechanisms native to pulmonary cells; childhood lung disease and its etiology; drug metabolism

Stuart J. Frank, M.D. - Medicine
Growth hormone action and GH receptor structure and function

Andra R. Frost, M.D. - Pathology
Fibroblast-epithelial cell interactions and developmental pathways in breast cancer

Kohtaro Fujihashi, D.D.S, Ph.D. - Pediatric Dentistry
The cellular and molecular mechanisms for mucosal immunity in the elderly; molecular and cellular mechanisms for the induction and regulation of mucosally induced tolerance; a mucosal internet of gd, ab T cells, and epithelial cells for mucosal immunity; mucosal immunity in murine models of IBD

Catherine Fuller, Ph.D. - Physiology & Biophysics
ENaC/ASIC Ion Channels

Mark Garfinkel, Ph.D. - Environmental Health Sciences
Drosophila

W. Timothy Garvey, M.D. - Nutrition Sciences
Molecular, metabolic, and genetic basis of type 2 diabetes mellitus, insulin resistance, and obesity

G. Yancey Gillespie, Ph.D. - Surgery
Molecular and viral therapy of malignant primary brain tumors

Gower, Barbara, Ph.D. - Nutrition Sciences
Gonadal steriod hormones

Alecia K. Gross, Ph.D. - Vision Sciences
Rhodopsin trafficking in rod cells and rhodopsin-mediated retinal degenerations

Lisa Guay-Woodford, M.D. - Genetics
Genetics of renal disease, particularly polycystic kidney disease

John Hablitz, Ph.D. - Neurobiology
Cellular mechanisms of neurotransmission

John L. Hartman, IV, M.D. - Genetics
Quantitative analysis of genotype-phenotype interaction networks in yeast models of human disease

Mohammad Hassan, Ph.D. - Oral and Maxillofacial Surgery
The regulation of bone formation and craniofacial development by non-coding microRNA. My research will also explore the role of specific microRNAs for the progression of osteoarthritis.

Hui-Chen Hsu, Ph.D. - Clinical Immunology, Rheumatology
The BXD2 autoimmune mouse model of lupus and erosive arthritis
Disease Mechanisms  Fundamental Cellular Mechanisms

Kejin Hu, Ph.D. - Biochemistry and Molecular Genetics
Somatic cell nuclear reprogramming, genetic modification of human pluripotent stem cells (PSC), pluripotency and self-renewal of pluripotent stem cells, and differentiation of PSC into blood lineage 

Douglas Hurst, Ph.D. - Pathology
Molecular mechanisms of cancer metastasis

Amjad Javed, Ph.D. - Oral and Maxillofacial Surgery
Genetic and molecular signaling for cellular differentiation and skeletogenesis

Kai Jiao, M.D., Ph.D. - Genetics
TGF-beta/Bmp signaling during cardiogenesis

Rajesh K. Kana, Ph.D. - Psychology
The neural substrates of social cognition and the impact of social cognition on language, communication, and other cognitive functions

Natalia Y. Kedishivili, Ph.D. - Biochemistry and Molecular Genetics
Regulation of retinoic acid homeostasis

Ilan Kerman, M.D. - Psychiatry

Bob Kesterson, Ph.D. - Genetics
Hypothalamic control of feeding behavior

Kent Keyser, Ph.D. - Vision Sciences
Acetylcholine and Ach receptors

Helen Kim, Ph.D. - Pharmacology & Toxicology
Proteomics of neuroprotective and chemopreventive actions of dietary phytochemicals

Jeonga Kim - Medicine
Cross-talk between inflammation and insulin signaling

Gwendalyn King, Ph.D. - Neurobiology
Understanding the difference between pathological and non-pathological brain aging

Kevin Kirk, Ph.D. - Physiology and Biophysics
The CFTR chloride channel

Adrienne Lahti, M.D. - Psychiatry & Behavioral Neurobiology
Use of multimodal brain imaging techniques to study the neuropathology of schizophrenia and bipolar disorder and to evaluate the effects of psychotopropic drugs on brain function and biochemistry; translational work aiming at bridging human brain imaging and postmortem studies

Jack Lancaster, Ph.D. - Anesthesiology
The biophysics and biochemistry of nitric oxide

Elliot Lefkowitz, Ph.D. - Microbiology
Viral and microbial genomics and evolution

Mathieu Lesort, Ph.D. - Psychiatry
Pathogenesis of Huntington's disease: From models to therapeutic targets

Xiaohua Li, M.D., Ph.D. - Psychiatry & Behavioral Neurobiology
Neurobiology of mood disorders
Yi-Ping Li, Ph.D. - Molecular and Cellular Pathology
Understanding the mechanisms of bone formation, bone resorption, skeletal development, craniofacial development and cancer bone metastasis; developing effective new therapies for treating and preventing the related diseases

Yonghe Li, Ph.D. - Medicine
Wnt signaling in cancer

Yuqing Li, Ph.D. - Neurology
Pathophysiology and experimental therapeutics of dystonia and related movement disorders; basal ganglia function and dysfunction; molecular and cellular mechanism of learning and synaptic plasticity

Farah Lubin, Ph.D. - Neurobiology
Molecular transcriptional mechanisms in learning/memory and neurological disorders

Jin-Biao Ma, Ph.D. - Biochemistry & Molecular Genetics
Structure and mechanism of proteins-RNA recognition in small RNA biogenesis and regulation

Lori McMahon, Ph.D. - Physiology & Biophysics
Synaptic plasticity and hippocampal dependent learning

Joseph L. Messina, Ph. D. - Pathology
Insulin and growth hormone (GH) action; insulin and GH resistance following trauma and infection 

Michael A. Miller, Ph.D. - Cell Biology
Function and evolution of intercellular communication mechanisms

John Mountz, M.D., Ph.D. - Medicine
Gene therapy, T-cell aging, immunogenetics, and T-cell imaging

Joanne Murphy-Ullrich, Ph.D. - Pathology
Extracellular matrix control of cell and growth factor function

Dobrawa Napierala, Ph.D. - Oral and Maxillofacial Surgery

Diana Noah, Ph.D. - Biochemistry/SRI
Understanding of influenza virus pathogenesis, including the mechanisms utilized by the highly pathogenic avian influenza strains causing deaths throughout Asia

Thomas T. Norton, Ph. D. - Vision Sciences
Animal models of myopia: Retinal control of eye size 

Susan Nozell, Ph.D. - Cell Biology

Michelle L. Olsen, Ph.D. - Physiology & Biophysics
Glial potassium channels and glutamate transporters in injury and abnormal development

Suzanne Oparil, M.D. - Medicine
Molecular and cellular mechanisms of cardiovascular disease

John Parant, Ph.D. - Pharmacology & Toxicology
Regulation as well as cause of genomic instability in cancer and other diseases

Vladimir Parpura, M.D. - Neurobiology
The role of glial cells in physiology of nervous system

Boris Pasche, M.D., Ph.D. - Medicine
Gene variants that modify cancer risk and novel cancer therapies

Andrew J. Paterson, Ph.D. - Medicine
The role of O-glycosylation in cell regulation and development

Ji-Bin Peng, Ph.D. - Medicine
Calcium transport proteins and their roles in health and disease

Steven Pittler, Ph.D. - Vision Sciences
Basic and Translational studies of photoreceptor metabolism and retinal degeneration

Steven Pogwizd, M.D. - Medicine
The electrophysiological and biochemical mechanisms underlying lethal arrhythmias in the setting of heart failure

Selvarangan Ponnazhagan, Ph.D. - Pathology
Adeno-associated virus gene therapy

Kirill M. Popov, Ph.D. - Biochemistry & Molecular Genetics
Regulation of pyruvate dehydrogenase complex

Edward M. Postlethwait, Ph.D. - Environmental Health Sciences
Environmental induction of pulmonary epithelial injury

Lucas Pozzo-Miller, Ph.D. - Neurobiology
Neurotrophins; Ca2+ signaling; synapse development and plasticity; mental retardation; Rett syndrome

Peter Prevelige, Jr., Ph.D. - Microbiology
Structural biology of viral assembly and infection

Chandler Raman, Ph.D. - Medicine
Lymphocyte activation, immune tolerance, and autoimmunity tolerance and autoimmunity

Sasanka Ramanadham, Ph.D. - Physiology & Biophysics
Beta-cell apoptosis bone metabolism insulin resistance/diabetes

Erik Roberson, M.D. Ph.D. - Neurology
Neurobiology of Alzheimer's disease and frontotemporal dementia

Tom Ryan Ph.D. - Biochemistry & Molecular Genetics
Stem cell therapies in animal models of human disease

Ralph D. Sanderson, Ph.D. - Pathology
Molecular regulation of the tumor microenvironment

David Schneider, Ph.D. - Biochemistry & Molecular Genetics
Control of RNA polymearase I transcription in the model eukarote Saccharomyces cerevisiae

Harry Schroeder, M.D., Ph.D. - Medicine
The development and function of lymphocyte antigen receptors; genetics of primary immune deficiency diseases

Lisa Schwiebert, Ph.D. - Physiology & Biophysics
Airway inflammation; lung function; asthma and exercise

Rosa Serra, Ph.D. - Cell Biology
Mechanism of TGF-action in developmental and disease processes

Bingdong Sha, Ph.D. - Cell Biology
Structural and functional studies of proteins involved in protein folding and translocations

John Shacka, Ph.D. - Pathology
Regulation of neuron death by the autophagy lysosome pathway

Anath Shalev, MD - Med - Endrocrinology, Diabetes & Metabolism

Sadeep Shrestha, Ph.D. - Epidemiology
Infectious disease epidemiology; genetic epidemiology

Peter Smith, Ph.D. - Physiology & Biophysics
The role of the membrane cytoskeleton in regulating the cell surface expression of epithelial transport proteins

Harald Sontheimer, Ph.D. - Neurobiology
The role of neuroglia in brain function and disease

Eric Sorscher, M.D. - Medicine
Cystic Fibrosis and Molecular Genetics; Patient Oriented Research

Giuseppe L. Squadrito - Environmental Health Sciences
Development, design and evaluation of dynamic multi-component molecular systems that can be used to understand

David G. Standaert, M.D., Ph.D. - Medicine/Neurology
Translational research in neurodegenerative diseases

David Sweatt, Ph.D. - Neurobiology
Signal transduction mechanisms in learning and memory

Elizabeth Sztul, Ph.D. - Cell Biology
Membrane traffic; protein degradation

Anne Theibert, Ph.D. - Neurobiology
Role of phosphoinositides in developmental neurobiology

Sunnie Thompson, Ph.D. - Microbiology
Translation initiation during viral infection, tumorigenesis, or under stress

Jaideep Thottassery, Ph.D. - Pathology
Cks1; Skp2; cell cycle; breast cancer; antiestrogen resistance; nucleosides; DNA methylation

Janusz Tucholski, Ph.D. - Psychiatry & Behavioral Neurobiology
Cellular and molecular biology of neuroblastoma; response of neuronal cells and neurons to stress

Thomas Van Groen, Ph.D. - Cell Biology
Amyloid angiopathy in cognitive dysfunction and Alzheimer's disease

Jacques Wadiche, Ph.D. - Neurobiology
Synaptic transmission and glutamate transporters

Linda Wadiche, Ph.D. - Neurobiology
The function of adult generated neurons

Hengbin Wang, Ph.D. - Biochemistry & Molecular Genetics
Role of histone modification in chromatin function

Jianbo Wang, Ph.D. - Cell Biology
A novel signaling pathway termed planar cell polarity (PCP) pathway and how this pathway regulates morphogenesis in mammals

Qin Wang, M.D., Ph.D. - Physiology & Biophysics
Regulation of GPCR cellular responses and in vivo functions
Disease Mechanisms 

Andrew B. West, Ph.D. - Neurobiology
Genetic and biochemical mechanisms in neurological disorders

C. Roger White, Ph.D. - Medicine/Cardiovascular Disease
Oxidant stress and endothelial dysfunction

Timothy M. Wick, Ph.D. - Biomedical Engineering
Orthopaedic and cardiovascular tissue engineering and regenerative medicine

Scott Wilson, Ph.D. - Neurobiology
Mouse models of neurodegeneration

Jianming Wu, D.V.M., Ph.D. - Medicine
Molecular immunology and genetics of human autoimmune diseases

J. Michael Wyss, Ph.D. - Cell Biology
Neuroplasticity in aging and neuro cardiovascular control

Eddy Yang, M.D., Ph.D. - Radiation Oncology
The targeting of DNA repair pathways to enhance the therapeutic ratio

Yang Yang, M.D., Ph.D. - Molecular and Cellular Pathology
Tumor microenvironment; cancer-related bone diseases; translational research on multiple myeloma

Qinglin Yang, Ph.D. - Nutrition Sciences
Exploring molecular mechanisms underlying the development and progression of heart failure, especially those related to transcriptional regulation of myocardial fatty acid and carbohydrate metabolisms (eg., PPAR signaling pathway) in pathological conditions such as hypertension, obesity, and diabetes

Bradley Yoder, Ph.D. - Cell Biology
Cilia signaling and dysfunction in development and disease

Martin E. Young, Ph.D. - Medicine/Cardiovascular Disease
Role of the circadian clock within the heart

Nabiha Yusuf, Ph.D. - Dermatology
Environmental influences such as chemical carcinogens and ultraviolet light on the skin and on the immune system

Majd Zayzafoon, M.D., Ph.D. - Pathology
The role of calcium signaling in the genetic and epigenetic pathogenesis of disease

Jianhua Zhang, Ph.D. - Pathology
Cell and molecular mechanisms; mouse models of autophagy in development; neurological and psychiatric diseases

Lufang Zhou, Ph.D. - Medicine
Oxidative stress induced mitochondrial dysfunction and cardiovascular disease

Kurt Zinn, D.V.M., M.S., Ph.D. - Radiology
The development of imaging approaches that can monitor molecular events in small animal models, particularly technologies that have the potential to translate to human applications are emphasized. Areas of interest include: (1) strategies to link blood-based screening with imaging for early detection of disease, especially cancer, and (2) imaging of protein-protein interactions.