Faculty & Research
Faculty in the CMDB theme are affiliated with multiple departments across UAB. The scientific interests of the faculty are very diverse and interdisciplinary in nature and encompass cell, molecular, and developmental biology using modern tools and approaches as well as a wide range of model organisms and cell culture systems. The research conducted by CMDB faculty addresses fundamental cellular and molecular questions that provide the basis for understanding and treating human disease and developmental abnormalities. Specific research activities of the CMDB faculty can be viewed by visiting individual faculty research and profile pages or by looking under the faculty research focus areas. CMDB faculty research is supported by awards from various agencies, with the majority coming from the National Institutes of Health.
Click on the research focus area in the menu bar on the left to see a listing of faculty members by research focus area.
Disease Mechanisms
Anupam Agarwal, M.D. - Medicine
Regulation of heme oxygenase gene expression in kidney and vascular injury
Disease Mechanisms Fundamental Cellular Mechanisms
Jonas Almeida, Ph.D.- Pathology
Informatics; personalized medicine; systems biology; mathematical modeling
Birth Defects & Development Disease Mechanisms Fundamental Cellular Mechanisms
G. M. Anantharamaiah, Ph.D. - Medicine
Apolipoproteins; amphipathic helices; atherosclerosis
Disease Mechanisms Fundamental Cellular Mechanisms
Daniel Balkovetz - Medicine
Epithelial cell biology; epithelial cell signal regulation; regulation of paracellular transport across epithelial cell
Disease Mechanisms Fundamental Cellular Mechanisms
Scott Ballinger, Ph.D. - Molecular and Cellular Pathology
Environmental cardiology; free radical biology; mitochondrial function
Disease Mechanisms Fundamental Cellular Mechanisms
Membrane protein biogenesis in epithelial cells (CFTR as model); unfolded protein response
Disease Mechanisms Fundamental Cellular Mechanisms
Mechanism of translation termination; therapies to suppress stop mutations
Disease Mechanisms Fundamental Cellular Mechanisms
The CFTR chloride channel control of epithelial sodium channel under physiological and pathological conditions Disease Mechanisms Fundamental Cellular Mechanisms
Cellular and molecular physiology of acid-base transporters and pH regulation Disease Mechanisms Fundamental Cellular Mechanisms
Molecular and cellular neurobiology; function of neuronal calcium sensors in health and disease Disease Mechanisms Fundamental Cellular Mechanisms
Molecular studies of astrocytes in health and disease Disease Mechanisms Fundamental Cellular Mechanisms
Lymphocyte development and function Disease Mechanisms Fundamental Cellular Mechanisms
Louise Chow, Ph.D. - Biochemistry & Molecular Genetics
Human papillomavirus DNA replication and pathogenesis Disease Mechanisms Fundamental Cellular Mechanisms
Sarah Clinton, Ph.D. - Psychiatry & Behavioral Neurobiology
Neurodevelopmental and environmental factors that underlie susceptibility to anxiety and depression Birth Defects & Development Disease Mechanisms
James Collawn, Ph.D. - Cell, Developmental and Integrative Biology
Cystic fibrosis; endocytosis; protein trafficking Disease Mechanisms Fundamental Cellular Mechanisms
Rita Cowell, Ph.D. - Psychiatry & Behavioral Neurobiology
Transcriptional regulation of early postnatal brain development: Insights into the pathology of autism and schizophrenia Birth Defects & Development Disease Mechanisms Fundamental Cellular Mechanisms
Disease Mechanisms
Disease Mechanisms
Alan Eberhardt, Ph.D. - Biomedical Engineering
Orthopedic and injury biomechanics, using both experimental and computational approaches Disease Mechanisms
Michelle Fanucchi, Ph.D. - Environmental Health Sciences
Pulmonary cell biology and toxicology; cell-to-cell interactions in the developing lung as well as in repair after lung injury and disease in children; the role of biochemical defense mechanisms native to pulmonary cells; childhood lung disease and its etiology; drug metabolism Disease Mechanisms
Disease Mechanisms Fundamental Cellular Mechanisms
Andra R. Frost, M.D. - Pathology
Fibroblast-epithelial cell interactions and developmental pathways in breast cancer Disease Mechanisms
Disease Mechanisms Fundamental Cellular Mechanisms
Alecia K. Gross, Ph.D. - Vision Sciences
Rhodopsin trafficking in rod cells and rhodopsin-mediated retinal degenerations Birth Defects & Development Disease Mechanisms
Disease Mechanisms Fundamental Cellular Mechanisms
Mohammad Hassan, Ph.D. - Oral and Maxillofacial Surgery
The regulation of bone formation and craniofacial development by non-coding microRNA. My research will also explore the role of specific microRNAs for the progression of osteoarthritis. Birth Defects & Development Disease Mechanisms Fundamental Cellular Mechanisms
Hui-Chen Hsu, Ph.D. - Clinical Immunology, Rheumatology
The BXD2 autoimmune mouse model of lupus and erosive arthritis Disease Mechanisms Fundamental Cellular Mechanisms
Amjad Javed, Ph.D. - Oral and Maxillofacial Surgery
Genetic and molecular signaling for cellular differentiation and skeletogenesis Birth Defects & Development Disease Mechanisms Fundamental Cellular Mechanisms
Birth Defects & Development Disease Mechanisms
Disease Mechanisms
Jeonga Kim - Medicine
Cross-talk between inflammation and insulin signaling Disease Mechanisms Fundamental Cellular Mechanisms
Gwendalyn King, Ph.D. - Neurobiology
Understanding the difference between pathological and non-pathological brain aging Disease Mechanisms Fundamental Cellular Mechanisms
Kevin Kirk, Ph.D. - Cell, Developmental and Integrative Biology
The CFTR chloride channel Disease Mechanisms Fundamental Cellular Mechanisms
Adrienne Lahti, M.D. - Psychiatry & Behavioral Neurobiology
Use of multimodal brain imaging techniques to study the neuropathology of schizophrenia and bipolar disorder and to evaluate the effects of psychotopropic drugs on brain function and biochemistry; translational work aiming at bridging human brain imaging and postmortem studies Disease Mechanisms Fundamental Cellular Mechanisms
Mathieu Lesort, Ph.D. - Psychiatry
Pathogenesis of Huntington's disease: From models to therapeutic targets Disease Mechanisms
Disease Mechanisms Fundamental Cellular Mechanisms
Yi-Ping Li, Ph.D. - Molecular and Cellular Pathology
Understanding the mechanisms of bone formation, bone resorption, skeletal development, craniofacial development and cancer bone metastasis; developing effective new therapies for treating and preventing the related diseases Disease Mechanisms
Disease Mechanisms Fundamental Cellular Mechanisms
Farah Lubin, Ph.D. - Neurobiology
Molecular transcriptional mechanisms in learning/memory and neurological disorders Disease Mechanisms Fundamental Cellular Mechanisms
Joseph L. Messina, Ph. D. - Pathology
Insulin and growth hormone (GH) action; insulin and GH resistance following trauma and infection Disease Mechanisms Fundamental Cellular Mechanisms
Disease Mechanisms
Disease Mechanisms Fundamental Cellular Mechanisms
Birth Defects & Development Disease Mechanisms Fundamental Cellular Mechanisms
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Disease Mechanisms Fundamental Cellular Mechanisms
John Parant, Ph.D. - Pharmacology & Toxicology
Regulation as well as cause of genomic instability in cancer and other diseases Birth Defects & Development Disease Mechanisms Fundamental Cellular Mechanisms
Birth Defects & Development Disease Mechanisms
Disease Mechanisms
Ji-Bin Peng, Ph.D. - Medicine
Calcium transport proteins and their roles in health and disease Disease Mechanisms Fundamental Cellular Mechanisms
Birth Defects & Development Disease Mechanisms
Disease Mechanisms Fundamental Cellular Mechanisms
Chandler Raman, Ph.D. - Medicine
Lymphocyte activation, immune tolerance, and autoimmunity tolerance and autoimmunity Disease Mechanisms
Sasanka Ramanadham, Ph.D. - Cell, Developmental and Integrative Biology
Beta-cell apoptosis bone metabolism insulin resistance/diabetes Disease Mechanisms Fundamental Cellular Mechanisms
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Harry Schroeder, M.D., Ph.D. - Medicine
The development and function of lymphocyte antigen receptors; genetics of primary immune deficiency diseases Disease Mechanisms
Lisa Schwiebert, Ph.D. - Cell, Developmental and Integrative Biology
Airway inflammation; lung function; asthma and exercise Disease Mechanisms
Rosa Serra, Ph.D. - Cell, Developmental and Integrative Biology
Mechanism of TGF-action in developmental and disease processes Birth Defects & Development Disease Mechanisms Fundamental Cellular Mechanisms
Bingdong Sha, Ph.D. - Cell, Developmental and Integrative Biology
Structural and functional studies of proteins involved in protein folding and translocations Disease Mechanisms Fundamental Cellular Mechanisms
John Shacka, Ph.D. - Pathology
Regulation of neuron death by the autophagy lysosome pathway Disease Mechanisms Fundamental Cellular Mechanisms
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Birth Defects & Development Disease Mechanisms Fundamental Cellular Mechanisms
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Disease Mechanisms Fundamental Cellular Mechanisms
Birth Defects & Development Disease Mechanisms
Sunnie Thompson, Ph.D. - Microbiology
Translation initiation during viral infection, tumorigenesis, or under stress Disease Mechanisms Fundamental Cellular Mechanisms
Jaideep Thottassery, Ph.D.- Pathology
Cks1; Skp2; cell cycle; breast cancer; antiestrogen resistance; nucleosides; DNA methylation Disease Mechanisms
Janusz Tucholski, Ph.D. - Psychiatry & Behavioral Neurobiology
Cellular and molecular biology of neuroblastoma; response of neuronal cells and neurons to stress Disease Mechanisms Fundamental Cellular Mechanisms
Thomas Van Groen, Ph.D. - Cell, Developmental and Integrative Biology
Amyloid angiopathy in cognitive dysfunction and Alzheimer's disease Disease Mechanisms Fundamental Cellular Mechanisms
Qin Wang, M.D., Ph.D. - Physiology & Biophysics
Regulation of GPCR cellular responses and in vivo functions Disease Mechanisms
Disease Mechanisms Fundamental Cellular Mechanisms
Birth Defects & Development Disease Mechanisms Fundamental Cellular Mechanisms
Disease Mechanisms
J. Michael Wyss, Ph.D. - Cell, Developmental and Integrative Biology
Neuroplasticity in aging and neuro cardiovascular control Disease Mechanisms
Eddy Yang, M.D., Ph.D. - Radiation Oncology
The targeting of DNA repair pathways to enhance the therapeutic ratio Disease Mechanisms Fundamental Cellular Mechanisms
Yang Yang, M.D., Ph.D. - Molecular and Cellular Pathology
Tumor microenvironment; cancer-related bone diseases; translational research on multiple myeloma Disease Mechanisms
Qinglin Yang, Ph.D. - Nutrition Sciences
Exploring molecular mechanisms underlying the development and progression of heart failure, especially those related to transcriptional regulation of myocardial fatty acid and carbohydrate metabolisms (eg., PPAR signaling pathway) in pathological conditions such as hypertension, obesity, and diabetes Disease Mechanisms Fundamental Cellular Mechanisms
Bradley Yoder, Ph.D. - Cell, Developmental and Integrative Biology
Cilia signaling and dysfunction in development and disease Birth Defects & Development Disease Mechanisms Fundamental Cellular Mechanisms
Nabiha Yusuf, Ph.D. - Dermatology
Environmental influences such as chemical carcinogens and ultraviolet light on the skin and on the immune system Disease Mechanisms
Disease Mechanisms
Jianhua Zhang, Ph.D. - Pathology
Cell and molecular mechanisms; mouse models of autophagy in development; neurological and psychiatric diseases Disease Mechanisms Fundamental Cellular Mechanisms
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Faculty & Research