CMDB Theme Overview
The Cell, Molecular, and Developmental Biology (CMDB) graduate theme is part of an umbrella graduate program in Biomedical Sciences that focuses on basic process in cell, molecular, and developmental biology and how defects in these processes result in human diseases and birth defects. CMDB students will receive comprehensive training and instruction in cell, molecular, and developmental biology using modern tools and approaches as well as a wide range of model organisms and cell culture systems. The overall goal of the theme is to develop well-rounded scholars with expertise applicable to multiple fields pertinent to a productive research and teaching career in academic science centers, research institutions, and industry.
Students are admitted into UAB Graduate Biomedical Sciences (GBS) umbrella program and indicate a theme preference. Applicants to the UAB Graduate School are reviewed by the GBS Admissions Committee and will be evaluated on the basis of their undergraduate performance (both the curriculum and grade point average), letters of recommendation, GRE scores, a personal statement of research interests, performance in other graduate programs or research activities and, if possible, a personal interview. Although students select a theme on admission into the GBS program, they may change theme affiliation at anytime; however, changes that occur late in the doctoral program may require additional fundamental course work related to the specific theme.
Acceptance into CMDB requires a bachelor's degree including undergraduate coursework in calculus, general and organic chemistry, and at least one introductory course in zoology or biology by the time of entrance. The CMBD theme invites applications from individuals committed to obtaining a graduate education in biomedical sciences. Applications are strongly encouraged from individuals with previous research experience, a master's degree in related area, or a professional degree such as the M.D. or D.V.M. Once accepted into GBS, students must complete the GBS core curriculum and three scientific research rotations in GBS laboratories. CMDB students will then begin course work in areas related to his/her research interests and training needs determined through the advice of faculty mentors and staff.
Overview of the CMDB Theme
The CMDB theme comprises more than 60 primary and secondary faculty members with appointments in many of the academic departments and Centers at UAB including Cell Biology, Genetics, Biochemistry, Neurobiology, Medicine, Oral and Maxillofacial Surgery, Nutrition Sciences, Cardiovascular Disease, Clinical Immunology, Rheumatology, Pathology, Environmental Health Sciences, Physiology and Biophysics, Psychiatry & Behavioral Neurobiology, Vision Sciences and Optometry. The scientific interests of the faculty are very diverse and interdisciplinary in nature. As such, the CMDB theme can provide students an individually tailored, comprehensive training program in cell, molecular, and developmental biology using modern tools and approaches in a wide range of model organisms. The research conducted by CMDB faculty addresses fundamental cellular and molecular questions that provide the basis for understanding and treating human disease.
In the first semester, all students accepted into the GBS program will complete a 10-week core course covering fundamentals in biochemistry, metabolism, genetics, and molecular and cellular biology. After completion of the core GBS curriculum, CMDB students will complete a course titled "Introduction to Experimental Medicine," which will introduce students to fundamental questions in biomedical sciences and the research approaches and model systems used to address them.
In addition, starting early in the first semester each student will obtain research experience through three laboratory rotations that will be completed by the end of the first year. Laboratory rotations are for 10 weeks and are an integral part of the first year curriculum. They are the first opportunity to truly experience what graduate level scientific research is all about. These rotations are highly structured and are meant for you to become acquainted with the laboratory and the mentor and to gain practical experience in a variety of the techniques and types of scientific questions being addressed within the different theme areas. At the end of each rotation the students will present their research in the form of a poster presentation that is open to the GBS community. After completion of the rotations, students choose a mentor and laboratory for their dissertation research.
In the second semester, CMDB students must attend Methods and Scientific Logic, a journal club designed to demonstrate how to critically evaluate data and experimental design in the scientific literature and research. In addition, beginning in the second semester CMDB students will complete a series of one-month modules in areas related to cell, molecular, and developmental biology that are in the general research and scientific interest of the individual student. The CMDB curriculum is tailored to the student’s research and scientific interests. As such, the student will be able to select from modules in the CMDB theme as well as from other GBS themes approved by the student’s mentor and the CMDB theme directors. The student must complete eight modules, five of which should be listed as a CMDB course. Additional course work may be required to fill gaps in the student’s knowledge based on the recommendation of the mentor and the student’s thesis committee.
In the summer of the first year, all CMDB students must complete course in biostatistics and bioethics as well as conduct non-dissertation research in their selected laboratories.
At the beginning of the second year, students will assemble a thesis committee in consultation with their mentors. This committee will be formed by anywhere between four and six members, three of whom should be faculty associated with the CMDB theme.
In the second year, students continue non-dissertation laboratory research and take module course work to fulfill the requirements described above. By the beginning of the third year, CMDB students must complete their qualifying examination consisting of a written dissertation research proposal in the format of an NIH-style grant and an oral defense. The examination will evaluate whether the student has gained a sufficiently broad knowledge necessary for successful academic research. To help in this process, the second-year curriculum will include a course in scientific writing and grantsmanship with a mock NIH grant review session. After successful completion of the exam, the proposal will be submitted to a funding agency (if applicable) for possible support.
After the second semester, all students must participate in a CMDB approved Departmental Seminar Series and a weekly journal club until completion of the doctoral degree.
The curriculum of each Ph.D. candidate usually requires five years of training and is individually tailored to the interests and needs of the student by the advisor and a graduate committee chosen by the student. The Ph.D. is awarded upon successful defense of your dissertation, which includes an oral presentation of original, creative scientific investigations, and a written dissertation which is expected to include published manuscripts or manuscripts in preparation. Because pursuit of the Ph.D. is a full-time activity, all graduate students are supported by monetary stipends and do not have any required teaching duties. The level of activity required does not permit outside jobs or excessive extracurricular activities. Continuous registration and satisfactory academic standing during all terms is required.
Course Descriptions - Cell, Molecular and Developmental Biology
Cell Signaling. This course covers major extracellular and intracellular signal transduction cascades that regulate animal development and physiology. The class meets every day for two hours and consists of two exams.
Introduction to Experimental Medicine. This six-week course will consist of interactive lectures, discussions, and scientific literature reviews demonstrating general principles in biomedical sciences and how defects in these processes are related to human disease or birth defects. Faculty will discuss scientific rationale, logic, and approaches to investigate these processes and provide examples from the primary literature or research ongoing in their laboratories. Students will be evaluated based on written assignments, participation in discussions, and a class presentation.
Cellular Membranes and Organelles. This class will cover molecular and cellular processes that are involved in the assembly and maintenance of membranes and organelles and how defects in these processes contribute to human disease.
Cell and Molecular Aspects of Developmental Biology. The goal of this course is to provide an introduction to the fundamentals of vertebrate developmental biology. The course will consist of faculty lectures and research paper discussion groups covering a broad range of developmental issues from fertilization to organogenesis.
Developmental Neuroscience. The course will utilize scientific literature and faculty lectures to cover a broad range of topics related to the mechanisms of building a brain. The topics covered range from neural induction in early development, to axonal guidance and synapse formation, to neuro-gial interactions in the adult nervous system. Grades will be based on two exams and student participation in class discussions.
Stem Cell Biology. This course will explore the derivation, manipulation, and differentiation of embryonic, fetal, and adult stem cells in both mice and humans. Topics to be discussed include stem cell self-renewal, teratoma formation, hematopoietic stem cells, neural stem cells, trans-differentiation, nuclear transfer, and reproductive and therapeutic cloning. The course will be a mixture of instructor lectures and interactive journal club style presentations from the current stem cell literature by the students. Students will be evaluated based upon their journal article presentations, participation in class discussions, quizzes, and attendance.
Development and Evolution.This course will cover the developmental mechanisms that drive evolutionary change and how body plans evolve through natural selection. The course consists of lectures and scientific literature discussions that will demonstrate developmental biology principles.
Skeletal Development and Disease. The primary goal of this course is to introduce graduate students to the basic and translational knowledge about development, maintenance and homeostasis of the mineralized tissues. Lectures in this course will focus on approaches and techniques that are utilized for understanding cellular and molecular mechanisms essential for the normal development, remodeling, and patho-physiology of skeleton.
Cell and Matrix Interactions in Disease and Development. This course will cover a combination of basic mechanisms underlying extracellular matrix interactions with cells, and how these go wrong in several disease processes. It will be a series of seminars, followed in the final week with oral student presentations on the disease of their choice and submission of a one-page summary.
Mechanisms of Birth Defects. This class will provide an overview of the mechanisms of common birth defects. A review of the development of each organ system is followed by a discussion of molecular mechanisms leading to alterations in normal development. Genetic and environmental mechanisms are discussed. A recent paper on each topic is presented as part of the class. Depending on the number of students enrolled, each student will be required to present one or two papers.
Grantsmanship and Scientific Writing. The objective of the course is to teach students how to effectively write grant proposals. This course will provide hands on training in the preparation of a grant application and demonstrate effective strategies for assembling a successful proposal. With guidance from the faculty, the students will write a NIH-style proposal on their dissertation research topic. After the proposal is complete, each grant will be reviewed in a mock-NIH study section. Based on the comments from the study section, the student will revise the application and submit the proposal to his/her thesis committee as part of the qualifying examination for admittance into candidacy.
Laboratory Rotations. Concurrent with the first year of course work, each student will perform laboratory research with mentors of his/her choosing in any of the GBS themes. Laboratory rotations are meant help students become acquainted with the laboratory and the mentor and to gain practical experience in a variety of the techniques and types of scientific questions being addressed within the different theme areas. Laboratory rotations last approximately ten weeks and each student will complete three rotations by the end of their first year. At the end of each rotation the students will present their research in the form of a poster. The performance in the laboratory and the poster presentation will be graded by the mentor of the laboratory and by two GBS faculty members respectively. A passing grade is required for all laboratory rotations. 1-6 hours.
Nondissertation Research. Laboratory research performed prior to admission to candidacy. 1-12 hours.
Dissertation Research. Prerequisite: Admission to candidacy. 1-12 hours.
CMDB Approved Seminar Series.All CMDB students must attend one of the weekly departmental based seminar series within the scientific interest of the student. The seminar series feature prominent speakers from both inside and outside of UAB and attendance is mandatory. Current approved seminar series include Cell Biology, Neuroscience, Genetics, and Biochemistry. Additional seminar series may be included upon approval of CMDB and the mentor.
CMDB Journal Clubs. In the beginning of the second year until completion of the thesis defense, all CMDB students must participate in a journal club related to the student’s research interests and to the CMDB theme. The purpose of the journal club is to give students valuable experience in critical assessment of the scientific literature and to keep up-to-date on the research activities emerging from CMDB related research. Current journal clubs associated with the CMDB theme are Autophagy and Cell Death, Cell Biology, Cell-Matrix Interactions, Cancer and Developmental Biology, and Stem Cell Biology. Additional journal clubs may be included upon approval of the CMDB director and co-director.