Graduate Biomedical Sciences Core Curriculum

Block 1 - Biochemistry/Metabolism

• Amino acids and primary protein structure
• Protein secondary and tertiary structure
• Postranslational modifications and allosteric changes
• Glycobiology
• Lipid structure and metabolism
• Thermodynamic principles of biochemical reactions
• Enzyme kinetics
• Enzyme mechanisms and regulation
• Amino acid/nitrogen metabolism
• Glycolysis, gluconeogenesis and citric acid cycle
• Glycogenesis, glycogenolysis and pentose phosphate pathway
• Electron transport/oxidative phosphorylation

Block 1 2011 Syllabus

Block 2 - Genetics/Molecular Biology

• DNA recombination
• Nucleic acids & DNA replication
• Prokaryotic transcription
• Prokaryotic translation
• Prokaryotic gene regulation
• Eukaryotic genome organization
• Eukaryotic DNA replication
• Eukaryotic transcription
• Eukaryotic translation
• Eukaryotic gene regulation I
• Eukaryotic gene regulation II
• Mendelian inheritance
• Genetic variation and polymorphisms

Block 2 2011 Syllabus

Block 3 - Biological Organization

• Integrated systems: From organelles to organs
• Membrane structure/function
• Cytoskeleton
• Secretion
• Endocytosis, lysosomal targeting, protein degradation
• Biochemistry of signal transduction
• Cell cycle
• Cell-cell junctions and polarity
• ECM and ECM-cell interactions
• Cell motility
• Apoptosis
• Discipline of pharmacology
• Pharmacokinetics

Block 3 2011 Syllabus