Maaike Everts, Ph.D. Assistant Professor Division of Human Gene Therapy Division of Molecular and Cellular Pathology Department of Pathology University of Alabama at Birmingham 901 19th Street South, BMR2-512 Birmingham, AL 35294 maaike@uab.edu Phone: (205) 975-7288 Fax: (205) 975-7949
Research Interests
My main research interest is the development of targeted adenoviral vectors that are able to selectively localize to diseased tissue after administration in the blood stream. An extension from this is the development of adenovirus-based multifunctional nanosized therapeutics, which are able to simultaneously achieve targeting, imaging and therapy of cancer. For this I participate in multidisciplinary teams with material scientists as well as scientists with expertise in laser optics.
Select List of Publications (13 out of 29)
Everts, M., R.J. Kok, S.A. Ásgeirsdóttir, B.N. Melgert, T.J.M. Moolenaar, G.A. Koning, M.J.A. van Luyn, D.K.F. Meijer, G. Molema. Selective intracellular delivery of dexamethasone into activated endothelial cells using an E-selectin directed immunoconjugate. J. Immunol., 2002, 168: 883-889. Everts, M., G.A. Koning, R.J. Kok, S.A. Ásgeirsdóttir, D. Vestweber, D.K.F. Meijer, G. Storm and G. Molema. In vitro cellular handling and in vivo targeting of E-selectin directed immunoconjugates and immunoliposomes used for drug delivery to inflamed endothelium. Pharm. Res., 2003, 20(1):64-72. Everts, M., S.A. Ásgeirsdóttir, R.J. Kok, J. Twisk, B. de Vries, E. Lubberts, E.J. Bos, N. Werner, D.K.F. Meijer, G. Molema. Comparison of E-selectin expression at mRNA and protein levels in murine models of inflammation. Inflam. Res., 2003, 52: 512-518. Le, L.P., M. Everts, I.P. Dmitriev, J.G. Davydova, M. Yamamoto, D.T. Curiel. Fluorescently labeled adenovirus with pIX-EGFP for vector detection. Mol. Imaging, 2004, 3(2): 105-116 Everts, M., D.T. Curiel. Transductional targeting of adenoviral cancer gene therapy. Curr. Gene Ther., 2004, 4(3): 337-346 Everts, M., S.A. Kim-Park, M.A. Preuss, M.J. Passineau, J.N. Glasgow, P.J. Mahasreshti, W.E. Grizzle, P.N. Reynolds, D.T. Curiel. Selective induction of tumor-associated antigens in murine pulmonary vasculature using double-targeted adenoviral vectors. Gene Ther., 2005, 12: 1042-1048 Everts, M. Targeted Therapies Directed to Tumor-Associated Antigens. Drugs of the Future, 2005, 30(10): 1067-76 Zharov, V. P., J.W. Kim, D.T. Curiel, M. Everts. Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy. Nanomedicine, 2005, 1(4): 326-345 Everts, M., V. Saini, J.L. Leddon, R.J. Kok, M. Stoff-Khalili, M.A. Preuss, C.L. Millican, G. Perkins, J.M. Brown, H. Bagaria, D.E. Nikles, D.T. Johnson, V. P. Zharov, D.T. Curiel. Covalently linked Au nanoparticles to a viral vector: potential for combined photothermal and gene cancer therapy. Nano Lett., 2006, 6(4):587-91 Saini, V., V.P. Zharov, C.S. Brazel, D.E. Nikles, D.T. Johnson, M. Everts. Combination of Viral Biology and Nanotechnology: New Applications in Nanomedicine. Nanomedicine, 2006, 2:200-206 Everts, M. Thermal Scalpel to Target Cancer. Exp Rev Med Device, 2007, Mar;4(2):131-6 Everts, M. Thermal Scalpel to Target Cancer. Exp Rev Med Device, 2007, Mar;4(2):131-6 Saini, V., J.C. Roth, L. Pereboeva, M. Everts. Importance of viruses and cells in cancer gene therapy. Advances in Gene, Molecular and Cell Therapy, 2007, in press
Biosketch
Current Positions

Academic Degrees
1998	Groningen University, The Netherlands M.Sc.
2002	Groningen University Institute for Drug Exploration, The Netherlands: Ph.D.

Postdoctoral Training
2002 - 2005	University of Alabama at Birmingham Division of Human Gene Therapy

Professional Societies and Memberships

American Society for Gene Therapy (ASGT), since 2003

National Postdoctoral Association (NPA), Charter Member since 2003

Federation of European Biochemical Societies (FEBS), since 2004

American Academy of Nanomedicine, Founding Member since 2005

International Association of Nanotechnology, since 2006

Editorial Board Memberships

Ad-hoc reviewer Cancer Research

Ad-hoc reviewer Nano Letters

Ad-hoc reviewer Journal of Pharmacy and Pharmacology

Ad-hoc reviewer Clinical Cancer Research

Ad-hoc reviewer Molecular Cancer Therapeutics

Member Editorial Board Global Science Books - Medical and Pharma Board; Gene, Molecular and Cell Therapy (Domain 9)