Joel N. Glasgow, Ph.D.
Assistant Professor
Department of Medicine
Division of Cardiovascular Disease
Division of Human Gene Therapy

408 Biomedical Research Building II
901 19th Street South
Birmingham, AL 35294

Email: jng@uab.edu
Office Phone: (205) 975-7531
Lab Phone: (205) 975-8768
FAX: (205) 975-7949


Research Interests

Our research interests are focused on the development of targeted adenovirus-based gene therapy vectors that have the capacity for self-directed and specific localization to the disease-affected target tissue. Our particular interests include vector development for use in gene therapy for cardiovascular disease, obstructive pulmonary disease and cancer. For virus-based vector systems, specific interactions between virus capsid proteins and cell-surface molecules determine the ability of the vector to deliver its genetic payload. We are currently involved in genetic modification of the fiber and other proteins of the adenovirus shell to provide specific gene delivery to clinically relevant target cells and tissue types.


Select List of Publications

  1. Lee, E.J., Glasgow, J., Leu, S.-F., Belduz, A.O. and Harman, J.G. Mutagenesis of the cyclic AMP receptor protein of Escherichia coli: targeting positions 83, 127, and 128 of the cyclic nucleotide binding pocket. (1994) Nucleic Acids Res. 22:2894-2901

  2. Gu, Z., Toliver-Kinsky, T., Glasgow, J.N., Cain, L., and Perez-Polo, J.R. NGF-Mediated alteration of NF-kB binding activity after partial immuno-lesion to rat cholinergic basal forebrain neurons. (2000) Intl. J. Dev. Neuroscience 18:455-468

  3. Glasgow, J.N. and Regino Perez-Polo. One path to cell death in the nervous system. (2000) Neurochem. Res. 25:1373-1383

  4. Glasgow, J. N., Wood, T. and Perez-Polo, J.R. Identification and characterization of NF-kappa B

  5. Qiu, J., Grafe, M.R., Schmura, S.M., Glasgow, J.N., Kent, T.A., Rassin, D.K., and Perez- Polo, J. Differential NF-kB regulation of the bcl-x gene expression in hippocampus and basal forebrain in response to hypoxia. (2001) J. Neuroscience Res. 64:223-234

  6. Glasgow, J.N., Qui, J., Rassin, D., Grafe, M., Wood, T. and Perez-Polo, J.R. Transcriptional regulation of the bcl-x gene by NF-kB is an element of hypoxic responses in the rat brain. (2001) Neurochem. Res. 26:647-659

  7. Haviv, Y.S., Takayama, K., Glasgow, J.N., Wang, M., Blackwell, J.L. Lei, X. and Curiel, D. T. A model system for the design of armed replicating adenoviruses using p53 as a candidate transgene (2002) Mol. Cancer Ther. 1:321-328

  8. Takayama, K., Reynolds, P.N., Short, J.J., Kawakami, Y., Adachi, Y., Glasgow, J.N., Krasnykh, V., Douglas, J.T. and Curiel, D.T. A Mosaic Adenovirus Possessing Ad5 and Ad3 Knobs Exhibits Expanded Tropism (2003) Virology 309:282-293.

  9. Glasgow, J.N., Bauerschmitz, G.J., Curiel, D.T. and Hemminki, A. Transductional and Transcriptional Targeting of Adenovirus for Clinical Applications (2004) Cur. Gene Ther. 4:1-15

  10. Glasgow, J.N., Kremer, E.J., Hemminki, A., Siegal, G.P., Douglas, J.T., and Curiel, D.T. An adenovirus vector with a chimeric fiber derived from canine adenovirus type 2 displays novel tropism (2004) Virology 324:103-116

  11. Breidenbach, M., Rein, D.T., Everts, M., Glasgow, J.N., Wang, M., Passineau, M.J., Alvarez, R.D., Korokhov, N., Curiel, D.T. Mesothelin-mediated

  12. M. Everts, Sang-Ae Kim-Park, P. N. Reynolds, Meredith A. Preus, Michael J. Passineau, Joel N. Glasgow, Parameshwar Mahasreshti, William E. Grizzle, David T. Curiel. Inducing Tumor Associated Antigens in Pulmonary Vasculature for Analysis of Targeting Strategies for Cancer Therapy (2005) Gene Ther. 12(13):1042-8

  13. Miiru Izumi, Yosuke Kawakami, Joel N. Glasgow, Natalya Belousova, Maaike Everts, SangAe Kim-Park, Seiji Yamamoto, Minghui Wang, Long P. Le, Paul N. Reynolds, and David T. Curiel. In vivo analysis of a genetically modified adenoviral vector targeted to human CD40 using a novel transient transgenic model (2005) J. Gene Med. 7(12):1517-25

  14. Mariam A. Stoff-Khalili, Angel A. Rivera, Joel N. Glasgow, Long P. Le, Alexander Stoff, Maaike Everts, Yuko Tsuruta, Yosuke Kawakami, Gerd. J. Bauerschmitz, J. Michael Mathis, Larisa Pereboeva, G. P. Seigal, Peter Dall, David T. Curiel. A Human Adenoviral Vector with a Chimeric Fiber from Canine Adenovirus Type 1 Results in Novel Expanded Tropism for Cancer Gene Therapy (2005) Gene Ther 12(23):1696-1706.

  15. Susan J Hedley, Adrian Auf der Maur, Susanne Hohn, Dominik Escher, Alcide Barberis, Joel N. Glasgow, Joanne T Douglas, Nikolay Korokhov, David T Curiel. An adenovirus vector with a chimeric fiber incorporating stabilized single chain antibody achieves targeted gene delivery. (2006) Gene Ther. 13(1):88-94

  16. Yuko Tsuruta, Larisa Pereboeva, Joel N. Glasgow, Cindy L. Luongo, Svetlana Komarova, Yosuke Kawakami, and David T. Curiel. Chimeric Reovirus s1 Fiber Incorporated into Adenovirus Serotype 5 Enhances Infectivity via a CAR Independent Pathway (2005) BBRC 335(1):205-14.

  17. Long P. Le, Angel A. Rivera, Joel N. Glasgow, Vladimir V. Ternovoi, Hongju Wu, Minghui Wang, Bruce F. Smith, Gene P. Siegal, David T. Curiel. Infectivity Enhancement for Adenoviral Transduction of Canine Osteosarcoma Cells (2006) Gene Ther 13(5):389-99

  18. J.N. Glasgow, M. Everts and D. T. Curiel. Adenovirus Targeting (2005) Cancer Gene Therapy Sept; 13(9):830-44.

  19. M. Nakayama, G.W. Both, B. Banizs, Y. Tsuruta, S. Yamamoto Y. Kawakami, J.T. Douglas, K. Tani, D.T. Curiel and J.N. Glasgow. An Adenovirus Serotype 5 Vector with Fibers Derived from Ovine Atadenovirus Demonstrates CAR-Independent Tropism and Unique Biodistribution. (2006) Virology Jun 20; 350(1):103-15

  20. Ilya V. Ulasov, Matthew Tyler, Yu Han, Joel N. Glasgow and Maciej S. Lesniak. A novel recombinant adenoviral vector that targets the IL13alpha2 receptor permits effective gene transfer to malignant glioma (2007) Hum Gene Ther 18(2):118-29

  21. Matthieu Perreau, Frank Mennechet, Nicolas Serratrice, Joel N. Glasgow, David T. Curiel, Harald Wodrich, and Eric J Kremer. Contrasting effects on the phenotypical and functional maturation of human dendritic cells by human, canine and hybrid adenovirus vectors: implication for clinical efficacy. (2007), J Virol 81(7):3272-84

  22. Yuko Tsuruta, Larisa Pereboeva, Joel N. Glasgow, Daniel T. Rein, Yosuke Kawakami, Ronald D. Alvarez, Rodney P. Rocconi, Gene P. Siegal, Paul Dent, Paul B. Fisher, and David T. Curiel. A Mosaic Fiber Adenovirus Serotype 5 Vector Containing Reovirus s1 and Adenovirus Serotype 3 Knob Fibers Increases Transduction in an Ovarian Cancer Ex Vivo System via a CAR-Independent Pathway. (2007), Clinical Cancer Research (In Press)

  23. Winan J. Van Houdt, Hongju Wu, Joel N. Glasgow, Martine L. Lamfers, Clemens M. Dirven, G.Yancey Gillespie, David T. Curiel and Yosef S. Haviv. Divergence in Gene Delivery into Malignant Glioma by Infectivity-Enhanced Adenovirus: in vivo vs. in vitro Models. (2007) Neuro-Oncology (In Press)


Biosketch

Positions

2006 - Present Assistant Professor UAB Department of Medicine Division of Cardiovascular Disease and Division of Human Gene Therapy
2006 - Present Associate Scientist, UAB Gene Therapy Center

Previous Positions

2004 - 2006 Research Associate, Division of Human Gene Therapy, University of Alabama at Birmingham, Birmingham, AL
2003 - 2004 Senior Scientist, VectorLogics, Inc., Birmingham, AL
2000 - 2003 Postdoctoral Fellow, Division of Human Gene Therapy, University of Alabama at Birmingham, Birmingham, AL

Academic Degrees

1994B.S. in Chemistry with Biology minor (Cum Laude), Texas Tech University, Lubbock, TX
2000Ph.D., Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX


Professional Societies

2004 - PresentAmerican Society for Gene Therapy