Qiana L. Matthews, Ph.D.
Instructor
Division of Human Gene Therapy
Department of Medicine
552 Biomedical Research Building II

901 19th Street South
Birmingham, AL 35294-2172, USA

Email: qlm@uab.edu
Phone: (205) 934-9910
Fax: (205) 975-7949


Research Interests

My current research involves molecular virology. In this context, I have utilized the human adenovirus vectors as a platform for cancer gene therapy, cellular imaging and vaccine schemas. The major theme of my research involves manipulating the adenovirus capsid proteins in order to optimize adenovirus-based vaccination.

Select List of Publications

  1. Johnson KP, Rowe GC, Jackson BA, D'Agustino JL, Campbell PE, Guillory BO, Williams MV, Matthews QL, McKay J, Charles GM, Verret CR, Deleon M, Johnson DE, Cooke DB. Novel antineoplastic isochalcones inhibit the expression of cyclooxygenase 1,2 and EGF in human prostate cancer cell line LNCaP. Cell Mol Biol (Noisy-le-grand). 2001 Sep;47(6):1039-45. PMID: 11785654.

  2. Volk AL, Rivera AA, Page GP, Salazar-Gonzalez JF, Nettelbeck DM, Matthews QL, Curiel DT. Employment of microarray analysis to characterize biologic differences associated with tropism-modified adenoviral vectors: utilization of non-native cellular entry pathways. Cancer Gene Ther. 2005 Feb;12(2):162-74. PMID: 15375380.

  3. Pereboev AV, Nagel JM, Shakmatov MA, Triozzi PL, Matthews QL, Kawakami Y, Curiel DT, Blackwell JL. Enhanced Gene Transfer to Mouse Dendritic Cells Using Adenoviral Vectors Coated with a Novel Adaptor Molecule. Mol Ther. 2004 May;9(5):712-20. PMID: 15120332.

  4. Stoff-Khalili MA, Stoff A, Rivera AA, Mathis JM, Everts M, Wang M, Kawakami Y, Waehler R, Matthews QL, Yamaoto M, Rocconi RP, Siegal GP, Richter DF, Dall P, Zhu ZB, Curiel DT. Gene Transfer to Carcinoma of the Breast with Fiber-Modified Adenoviral Vectors in a Tissue Slice System. Cancer Biol Ther. 2005 Nov; 4 (11):1203-1210. PMID: 16177567.

  5. Matthew QL, Sibley DA, Wu H, Li J, Stoff-Khalili MA, Waehler R, Mathis JM, and Curiel DT. Genetic incorporation of a herpes simplex virus type I thymidine kinase and firefly luciferase fusion into the adenovirus protein IX for Functional Display on the virion. Molecular Imaging. Vol 5, No 4 (Oct-Dec 2006) pp.510-519. PMID: 17150163.

  6. Stoff-Khalili MA, Rivera AA, Stoff A, Michael Mathis J, Rocconi RP, Matthews QL, Numnum MT, Herrmann I, Dall P, Eckhoff DE, Douglas JT, Siegal GP, Zhu ZB, Curiel DT. Combining high selectivity of replication via CXCR4 promoter with fiber chimerism for effective adenoviral oncolysis in breast cancer. Int J Cancer. 2007 Feb 15;120(4):935-41. PMID: 17131341.

  7. Matthews QL and Curiel DT. Gene therapy: human germline genetic modifications--assessing the scientific, socioethical, and religious issues. South Med J. 2007 Jan;100(1):98-100. PMID: 17269544.8.
  8. Matthews QL and Curiel DT, (2008) "Vector Targeting". In: Concepts in Genetic Medicine. New Jersey. John Wiley & Sons Inc.

  9. Tang Y, Le LP, Matthews QL, Han T, Wu H, and Curiel DT. Three types of pIX can be incorporated into one adenovirus virion. Virology. 2008 Aug 1;377(2):391-400. PMID: 18570971 PMC- In Process

  10. Matthews QL, Yang P, Wu Q, Belousova N, Rivera AA, Stoff-Khalili MA, Waehler R, Hsu H, Li Z, Li J, Mountz JD, Wu H and Curiel DT, Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach. Virol J. 2008 Aug 21;5(1):98. PMCID:PMC2535600

  11. Lopez MV, Matthews QL, Zinn KR, Curiel DT and Borovjagin AV. Imaging in Vector Development (chapter 43) in Molecular Imaging: Principles and Practice. Edited by R.Weissleder, S.S. Gambhir, B.D. Ross, A. Rehemtulla. BC Decker Inc, Publisher. (in press).

  12. Thacker E, Timares L, and Matthews QL. Strategies to overcome host immunity to adenoviral vectors in vaccine development. Expert Review of Vaccines (accepted).


Biosketch

Current Positions

2008 - Present Instructor. University of Alabama at Birmingham, Departments of Medicine, Obstetrics and Gynecology, Pathology and Surgery, Division of Human Gene Therapy

Previous Positions

2007 - 2008 Postdoctoral Fellow. University of Alabama at Birmingham, Departments of Medicine, Obstetrics and Gynecology, Pathology and Surgery, Division of Human Gene Therapy
2006 - 2007 Adjunct Assistant Professor, Samford University
2003 - 2007 Postdoctoral Trainee. University of Alabama at Birmingham, Departments of Medicine, Obstetrics and Gynecology, Pathology and Surgery, Division of Human Gene Therapy
1999Laboratory technician, Morehouse College, Department of Biology
1998Laboratory technician, Clark Atlanta University, Department of Biology

Academic Degrees

2003PhD in Biochemistry. Meharry Medical College, Nashville TN
1999BS in Biological Sciences. Clark Atlanta University, Atlanta GA


Ad Hoc Reviewer

Laboratory Investigation