Alexander Pereboev, M.D., Ph.D.
Assistant Professor
Division of Human Gene Therapy
Department of Medicine

406 Biomedical Research Building II
901 19th Street South
Birmingham, AL 35294-2172, USA

Email: pereboev@uab.edu
Phone: (205) 975-8734
Fax: (205) 975 8565

Research Interests

My research interests include gene delivery to target cells and to the sites of microbial pathogens primary attack. As a means to deliver therapeutic/protecting genes we use recombinant adenovirus. Our major efforts are concentrated on alteration of the virus tropism by employment of molecular adaptors and direct genetic modifications of viral capsid. The arsenal of methods we use in our studies includes phage display for identification of target-specific ligands, recombinant antibody technology, modern methods of molecular biology and gene engineering.

Select List of Publications

  1. Loktev VB, Ilyichev AA, Eroshkin AM, Karpenko LI, Pokrovsky AG, Pereboev AV, Svyatchenko VA, Ignat'ev GM, Smolina MI, Melamed NV, Lebedeva CD and Sandakhchiev LS, 1996, Design of immunogens as components of a new generation of molecular vaccines, J Biotechnol, 44, 129-37.

  2. Pereboev A and Morris GE, 1996, Reiterative screening of phage-display peptide libraries with antibodies, in: Epitope mapping protocols, G. E. Morris, Methods Mol Biol, Humana Press, Totowa, NJ, 195-206.

  3. Pereboev AV, Razumov IA, Svyatchenko VA and Loktev VB, 1996, Glycoproteins E2 of the Venezuelan and eastern equine encephalomyelitis viruses contain multiple cross-reactive epitopes, Arch Virol, 141, 2191-205.

  4. Kazachinskaia EI, Pereboev AV, Chepurnov AA, Belanov EF and Razumov IA, 2000, [Monoclonal antibodies to Ebola virus: isolation, characteristics, and study of cross reactivity with Marburg virus], Vopr Virusol, 45, 40-4.

  5. Pereboev a LA, Pereboev AV, Wang LF and Morris GE, 2000, Hepatitis C epitopes from phage-displayed cDNA libraries and improved diagnosis with a chimeric antigen, J Med Virol, 60, 144-51.

  6. Pereboev A, Pereboeva L and Curiel DT, 2001, Phage display of adenovirus type 5 fiber knob as a tool for specific ligand selection and validation, J Virol, 75, 7107-13.

  7. Hakkarainen T, Hemminki A, Pereboev AV, Barker SD, Asiedu CK, Strong TV, Kanerva A, Wahlfors J and Curiel DT, 2003, CD40 is expressed on ovarian cancer cells and can be utilized for targeting adenoviruses, Clin Cancer Res, 9, 619-24.

  8. Korokhov N, Mikheeva G, Krendelshchikov A, Belousova N, Simonenko V, Krendelshchikova V, Pereboev A, Kotov A, Kotova O, Triozzi PL, Aldrich WA, Douglas JT, Lo KM, Banerjee PT, Gillies SD, Curiel DT and Krasnykh V, 2003, Targeting of adenovirus via genetic modification of the viral capsid combined with a protein bridge, J Virol, 77, 12931-40.

  9. Leath CA, 3rd, Kataram M, Bhagavatula P, Gopalkrishnan RV, Dent P, Fisher PB, Pereboev A, Carey D, Lebedeva IV, Haisma HJ, Alvarez RD, Curiel DT and Mahasreshti PJ, 2004, Infectivity enhanced adenoviral-mediated mda-7/IL-24 gene therapy for ovarian carcinoma, Gynecol Oncol, 94, 352-62.

  10. Pereboev AV, Nagle JM, Shakhmatov MA, Triozzi PL, Matthews QL, Kawakami Y, Curiel DT and Blackwell JL, 2004, Enhanced gene transfer to mouse dendritic cells using adenoviral vectors coated with a novel adapter molecule, Mol Ther, 9, 712-20.

  11. Short JJ, Pereboev AV, Kawakami Y, Vasu C, Holterman MJ and Curiel DT, 2004, Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors, Virology, 322, 349-59.

  12. Everts M, Kim-Park SA, Preuss MA, Passineau MJ, Glasgow JN, Pereboev AV, Mahasreshti PJ, Grizzle WE, Reynolds PN and Curiel DT, 2005, Selective induction of tumor-associated antigens in murine pulmonary vasculature using double-targeted adenoviral vectors, Gene Ther, 12, 1042-8.

  13. Passineau MJ, Siegal GP, Everts M, Pereboev A, Jhala D, Wang M, Zhu ZB, Park SK, Curiel DT and Nelson GM, 2005, The natural history of a novel, systemic, disseminated model of syngeneic mouse B-cell lymphoma, Leuk Lymphoma, 46, 1627-1638.

  14. Short JJ, Vasu C, Holterman MJ, Curiel DT and Pereboev A, 2006, Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors, Virus Res, 122, 144-53.

  15. Yoshio-Hoshino N, Adachi Y, Aoki C, Pereboev A, Curiel DT and Nishimoto N, 2007, Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor, Cancer Res, 67, 871-5.




Biosketch

Current Positions

2001 - present Research Assistant Professor. University of Alabama at Birmingham, Departments of Medicine, Pathology and Surgery, Division of Human Gene Therapy

2003 - present Associate Scientist. University of Alabama at Birmingham Department of Pathology; Division of Molecular and Cellular Pathology.

2003 - present Associate Scientist. University of Alabama at Birmingham Gene Therapy Center

2005 - present Associate Scientist. University of Alabama at Birmingham
Comprehensive Cancer Center


Previous Positions

2000-2001 Research Associate UAB; Departments of Medicine, Pathology and Surgery, Division of Human Gene Therapy

1997 - 2000 Postdoctoral Fellow UAB; Departments of Medicine, Pathology and Surgery, Gene Therapy Center

1995 - 1997 Visiting Scientist North East Wales Institute; Wrexham, UK; MRIC Biochemistry Group;

1992 - 1995 Senior Scientist Institute of Molecular Biology; Koltsovo, Novosibirsk, Russia

1986 - 1992 Scientist Institute of Molecular Biology; Koltsovo, Novosibirsk, Russia

1984 - 1986 Junior Scientist Institute of Molecular Biology; VECTOR; Koltsovo, Novosibirsk, Russia

Awards

1992 Individual G. Soros Grant to Outstanding Scientists of the Former Soviet Union.

Administrative duties DHGT

Web Site

Academic Degrees

1984 MD. Tomsk State Medical University. Tomsk, Russia
1992 PhD in Virology. Institute of Molecular Biology, VECTOR; Koltsovo, Novosibirsk, Russia.