Zeng Bian Zhu, M.D.
Assistant Professor
Division of Human Gene Therapy
Deptartment of Pathology

534 Biomedical Research Building II 901 19th Street South Birmingham, AL 35294-2172, USA

Email: Zeng.zhu@ccc.uab.edu
Phone: 205 934-0573
Fax: (205) 975 7476

Research Interests

My research interests are 1) screening tumor specific promoters for tumor transcriptional targeting; 2) developing the adenovirus fiber modifications for enhancement of viral infectivity; 3) designing and constructing CRAd agents for targeting tumor cells with high efficacy.


Select List of Publications

  1. Zeng B Zhu, Sharmila K Makhija, Baogen Lu, Minghui Wang, Lioudmila Kaliberrova, Bin Liu, Angel A Rivera, Dirk M Nettelbeck, Parameshwar J Mahasreshti, Charles A Leath III, Masato Tamota, Ronald D Alvarez, and David T Curiel. Transcriptionally Targeted Recombinant Adenoviral Vector Expression in Tumors Through the CXCR4 Tumor Specific Promoter. Gene Therapy 2004; 11:645-8

  2. Zeng B Zhu, Sharmila K Makhija, Baogen Lu, Minghui Wang, Lioudmila Kaliberrova, Bin Liu, Angel A Rivera, Dirk M Nettelbeck, Parameshwar J Mahasreshti, Charles A Leath III, Shannon Barker, Masato Tamota, Fengzhi Li, Ronald D Alvarez, and David T Curiel. Transcriptionally Targeting Tumor with a Novel Tumor-Specific Promoter, The Survivin Promoter. Cancer Gene Therapy 2004;11:256-62

  3. Yosef S Haviv, Winan J. van Houdt, Minghui Wang, Seiji Naito, Xiaosheng Lei, Baogen Lu, David T. Curiel, and Zeng Bian Zhu. Targeting Renal Cancer via the CXCR4 Promoter. Mol Cancer Ther. 2004; 3:687-91.

  4. Zhu ZB, Makhija SK, Lu B, Wang M, Rivera AA, Press M, Zhou F, Siegal GP, Alvarez RD, Curiel DT. Transport across a polarized monolayer of Caco-2 cells by transferring receptor-mediated adenovirus transcytosis. Virology 2004; 325:116-28.

  5. Baogen Lu, Sharmila K Makhija, Dirk M Nettelbeck, Angel A Rivera, Minghui Wang, Svetlana Komarova, Fen Zhou, Masato Yamamoto, Hidde J. Haisma, Ronald D. Alvarez, David T Curiel, and Zeng B Zhu, Evaluation of Tumor-Specific Promoter Activities in Melanoma. Gene Therapy 2005; 12:330-338.

  6. Zeng B. Zhu, Sharmila K. Makhija, Baogen Lu, Minghui Wang, Angel A. Rivera, SangAe Kim-Park, Ilya V. Ulasov, Fen Zhou, Ronald D. Alvarez, Gene P. Siegal, and David T. Curiel. Incorporating the Survivin Promoter in an Infectivity Enhanced CRAd-Analysis of Oncolysis and Anti-tumor Effects in vitro and in vivo. Inter J.Oncol. 2005; 27:237-46.

  7. Stoff-Khalili MA, Stoff A, Rivera AA, Mathis JM, Everts M, Wang M, Kawakami Y, Waehler R, Mathews QL, Yamamoto M, Rocconi RP, Siegal GP, Richter DF, Dall P, Zhu ZB, Curiel DT. Gene Transfer to Carcinoma of the Breast with Fiber-Modified Adenoviral Vectors in a Tissue Slice Model System. Cancer Biol Ther. 2005; 4:1203-1210.

  8. Passineau MJ, Siegal GP, Evert M, Pereboev A, Jhala D, Wang M, Zhu ZB, Park SK, Curiel DT, Nelson GM. The natural history of a novel, systemic, disseminated model of syngeneic mouse B-cell lymphoma.Leuk Lymphoma. 2005; 46:1627-1638.

  9. Stoff-Khalili MA, Stoff A, Rivera AA, Banerjee NS, Everts M, Young S, Siegal GP, Richter DF, Wang M, Dall P, Mathis JM, Zhu ZB, Curiel DT. Preclinical evaluation of transcriptional targeting strategies for carcinoma of the breast in a tissue slice model system. Breast Cancer Res. 2005; 7(6):R1141-52.

  10. Curiel, DT, Zhu, ZB. Combining chemotherapy with virotherapy: a novel treatment strategy for malignant pleural mesothelioma. Cancer Biol Ther. 2006; 5:236-7.

  11. Zeng B. Zhu, Sharmila K. Makhija, Baogen Lu, Minghui Wang, Shuyi Wang, Koichi Takayama, Gene P. Siegal, Paul N. Reynolds, and David T. Curiel. Targeting Mesothelioma Using an Infectivity Enhanced Survivin-CRAd. Journal of Thoracic Oncology 2006; 1:701-711

  12. Van Houdt W; Haviv Y, Lu B, Wang M, Rivera AA, Ulasov I, Lamfers M, Lesniak M, Siegal G, Clemens MF, Curiel D, and Zhu Z: The human survivin promoter is a novel transcriptional targeting strategy for glioma. Journal of Neurosurgery 2006; 104:583-92

  13. J. Michael Mathis, Phoebe L. Stewart, Zeng B. Zhu, and David T. Curiel. Advanced Generation Adenoviral Virotherapy Agents Embody Enhanced Potency Based Upon CAR-Independent Tropism. Clin Cancer Res 2006; 12:2651-6

  14. Zeng Bian Zhu, Yabing Chen, Sharmila K. Makhija, Baogen Lu, Minghui Wang, Angel A.Rivera, Masato Yamamoto, Shuyi Wang, Gene P. Siegal, David T. Curiel, and Jay M. McDonald. Survivin Promoter-Based Conditionally Replicative Adenoviruses Target Cholangiocarcinoma. Inter J.Oncol 2006; 29: 1319-29

  15. Zeng B. Zhu, Angel A. Rivera, Sharmila K. Makhija, Baogen Lu, Minghui Wang, Miiru Izumi, Robert Cerfolio, Mariam A. Stoff-Khalili, Fen Zhou, Koichi Takayama, Gene P. Siegal, and David T. Curiel. Targeting Lung Cancer Using an Infectivity Enhanced CXCR4-CRAd. Lung Cancer 2007; 55:145-56.

  16. Rocconi RP, Numnum MT, Zhu ZB, Lu B, Wang M, Rivera AA, Stoff-Khalili M, Alvarez RD, Curiel DT, Makhija S. Icodextrin enhances survival in an intraperitoneal ovarian cancer murine model utilizing gene therapy. Gynecol Oncol. 2006; 103:985-9.

  17. Belousova N, Harris R, Zinn K, Rhodes-Selser MA, Kotov A, Kotova O, Wang M, Aurigemma R, Zhu ZB, Curiel DT, Alvarez RD. Circumventing recombination events encountered with production of a clinical-grade adenoviral vector with a double-expression cassette. Mol Pharmacol. 2006; 70:1488-93.

  18. Chen Y, Xu J, Jhala N, Pawar P, Zhu ZB, Ma L, Byon CH, McDonald JM. Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3'-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory protein. Am J Pathol. 2006; 169:1833-42.

  19. Stoff-Khalili MA, Rivera AA, Stoff A, Michael Mathis J, Rocconi RP, Matthews QL, Numnum MT, Herrmann I, Dall P, Eckhoff DE, Douglas JT, Siegal GP, Zhu ZB, Curiel DT. Combining high selectivity of replication via CXCR4 promoter with fiber chimerism for effective adenoviral oncolysis in breast cancer. Int J Cancer. 2007; 120:935-41.

  20. Tang Y, Han T, Everts M, Zhu ZB, Gillespie GY, Curiel DT, Wu H. Directing adenovirus across the blood-brain barrier via melanotransferrin (P97) transcytosis pathway in an in vitro model. Gene Ther. 2007; 14:523-32.

  21. Rocconi RP, Zhu ZB, Stoff-Khalili M, Rivera AA, Lu B, Wang M, Alvarez RD, Curiel DT, Makhija SK. Treatment of ovarian cancer with a novel dual targeted conditionally replicative adenovirus (CRAd). Gynecol Oncol. 2007; 105:113-21.

  22. Zheng S, Ulasov IV, Han Y, Tyler MA, Zhu ZB, Lesniak MS. Fiber-knob modifications enhance adenoviral tropism and gene transfer in malignant glioma. J Gene Med. 2007; 9:151-60.

  23. Ulasov IV, Rivera AA, Sonabend AM, Rivera LB, Wang M, Zhu ZB, Lesniak MS. Comparative Evaluation of Survivin, Midkine, and CXCR4 Promoters for Transcriptional Targeting of Glioma Gene Therapy. Cancer Biol Ther. 2007; 3:6


Biosketch


Current Position

2002 - present Assistant Professor. University of Alabama at Birmingham, Departments of Pathology, Division of Human Gene Therapy



Previous Position

1998 - 2002 Assistant Professor. University of Alabama at Birmingham, Departments of Pathology.
1993 - 1998 Assistant Professor. University of Alabama at Birmingham, Departments of Medicine, Division of Rheumatology/Clinical Immunology
1987 - 1993 Research fellow. University of Alabama at Birmingham, Departments of Medicine, Division of Rheumatology/Clinical Immunology