Please cite grant number P30 DK074038.
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Cystic Kidney and Cilia Related Mouse Lines Generated or Available in Core B |
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Gene
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Clone #
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Source
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Mutation Type
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Human Disease
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Status/
Null Phenotype
|
Availability
|
Disease Complex or Function
|
# of Chimeras
|
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MKS Alleles
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B9d1
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Eppb9
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Eucomm
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Conditional
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MKS
|
E. Lethal
|
Available
|
MKS complex
|
20
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Mks1
|
C7, D9
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Eucomm
|
Conditional
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MKS
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Chimera/ Injecting
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NA
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MKS complex
|
1
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Cc2d2a
(Mks-6)
|
AA0274
|
MMRRC
|
Gene Trap
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MKS
|
Lethal
|
In Quality Control
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MKS Complex
|
11
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Cc2d2a
(Mks6)
|
C03
A06
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Eucomm
|
Conditional
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MKS
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Chimera/ Injecting
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NA
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MKS Complex
|
3
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RpGrip1L
(Mks-5)
|
A04, A02, A01
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Eucomm
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Conditional
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MKS
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Chimera/Injecting
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NA
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MKS Complex
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1
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NPHP Alleles
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Nphp1
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JM8.N4
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Eucomm
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Conditional
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NPHP
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Chimera
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NA
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NPHP Complex
|
5
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Nphp4
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C57BL/6J-nmf192/J
|
Jackson Labs
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Chemical
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NPHP
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Male sterile and blind
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Jackson Labs
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NPHP Complex
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NA
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BBS Alleles
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BBS4
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Bbs4tm1Vcs/J
|
Jackson Labs
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KO
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BBS
|
Viable Obese
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Jackson Labs
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BBSome
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NA
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BBS9
|
CSH755
|
MMRRC
|
Gene Trap
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BBS
|
Germline/
Being Analyzed
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In Quality Control
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BBSome
|
6
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IFT Alleles
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Ift140
|
F01
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Komp
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Conditional
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Viable
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In Quality Control
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IFT Complex A
|
8
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Cluap1
(Dyf3)
|
B01
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Komp
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Conditional
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Early Gestational Lethal
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Available
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IFT Complex B
|
4
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TRAF-3IP
(IFT54)
|
Rj0005
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MMRRC
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Gene Trap
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Early Gestational Lethal
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Available
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IFT Complex B
|
3
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IFT88 Flox
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Target at UAB
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UAB
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Conditional
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Viable
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Available
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IFT Complex B
|
4
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IFT88-ORPK
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NA
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ORNL
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Insertional Mutant
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Viable- Cystic Disease
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Available
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IFT
Complex B
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NA
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IFT88-KO
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NA
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ORNL
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Null
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Germline/ Lethal
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Available
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IFT
Complex B
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NA
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Cilia Proteome Gene Alleles
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Ccdc42
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ADL2
|
Komp
|
Target Null
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Viable
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Male Sterile
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Unknown
|
7
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Rabl4
(IFT27)
|
14917 A-A12, 14917A-F5
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Komp
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Target Null
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Perinatal Lethal
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Available
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Unknown
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NA
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Rabl4
(IFT27)
|
E10
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Eucomm
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Conditional
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Chimera
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NA
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NA
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NA
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Rabl5
|
AC7
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Komp
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Target Null
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Viable
|
Available
|
IFT Associated
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NA
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D430042009Rik
|
RRG309
|
MMRRC
|
Gene Trap
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Early Postnatal Lethal- Hydrocephalic
|
Available
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Unknown
|
3
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Gtl3
|
XA021
|
MMRRC
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Gene Trap
|
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Early Lethal
|
Available
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Unknown
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8
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Gas8
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CH0760
|
MMRRC
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Gene Trap
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Early Postnatal Lethal - Hydrocephalic
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Available
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Dynein Regulator Complex
|
4
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Tcf712
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Eucomm
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Conditional
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Chimeras
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NA
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Tsc. Factor
|
9
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Septin-2
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Eucomm
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Conditional
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Injecting
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NA
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Cilia diffusion barrier
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|
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Other Cilia Related Mouse Lines
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SSTR3-GFP Tag
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NA
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UAB
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Conditional Expression
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Germline
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NA
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Inducible Cilia Tag Mouse
|
8
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