Overview of ongoing projects. Glutamate Receptors Cortical expression of ionotropic glutamate receptor subunits in schizophrenia, major depression, and bipolar disorder. NMDA receptor phosphorylation states in schizoprenia Metabotropic Glutamate Receptor Protein Expression in the Prefrontal Cortex and Striatum in Schizophrenia Analysis of posttranslational glycosylation of glutamate receptor subunits in schizophrenia Fractionation of subcellular structures from postmortem brain tissue. Glutamate Receptor-Associated Intracellular Molecules Cortical expression of PSD proteins in schizophrenia, major depression, and bipolar disorder. Striatal expression of transcripts for NMDA associated PSD proteins in schizophrenia, major depression and bipolar disorder Cortical expression of NMDA receptor subunits and PSD proteins in schizophrenia Analysis of the interaction between metabotrophic and ionotrophic glutamate receptors in schizophrenia Analysis of NMDA related trafficking molecules in schizophrenia NMDA receptor subunit and PSD protein mRNA expression in hippocampus of human postmortem brain samples. Thalamic expression of NMDAR subunits and associated PSD protein transcripts following exposure to antipsychotic drugs. Glutamate Transporters (click on image to enlarge) Characterization of excitatory amino acid transporter interacting proteins in the cortex in schizophrenia. Excitatory amino acid transporter (EAAT) expression in the prefrontal cortex and thalamus in schizophrenia. Expression of vesicular glutamate transporters (vGLUTs) in the medial temporal lobe in severe psychiatric illness. Expression of vesicular and excitatory amino acid transporters in the Old World monkey brain. Modulation of excitatory amino acid transporter (EAAT) expression with Sindbis virus vectors in rodent brain slices. Expression of glutamate transporter - associated protein transcripts in thalamic nuclei from postmortem human brain samples. Effects of antipsychotic medication Assessment of treatment with psychotropic medications in the rodent brain. Antipsychotic project: clozapine and haloperidol Other molecules involved in glutamate neurotransmission Altered myelination in schizophrenia. Glial abnormalities in schizophrenia. Molecules associated with dopaminergic neurotransmission Studies of Dopamine Receptor Transcript Abnormalities in the Cortex and Striatum in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder. Studies of Intracellular Molecules Associated with Dopamine Transmission: Focus on Calcyon.
Glutamate Receptors
Metabotropic Glutamate Receptor Protein Expression in the Prefrontal Cortex and Striatum in Schizophrenia
Analysis of posttranslational glycosylation of glutamate receptor subunits in schizophrenia
Fractionation of subcellular structures from postmortem brain tissue.
Glutamate Receptor-Associated Intracellular Molecules
Striatal expression of transcripts for NMDA associated PSD proteins in schizophrenia, major depression and bipolar disorder
Cortical expression of NMDA receptor subunits and PSD proteins in schizophrenia
Analysis of the interaction between metabotrophic and ionotrophic glutamate receptors in schizophrenia
Analysis of NMDA related trafficking molecules in schizophrenia
NMDA receptor subunit and PSD protein mRNA expression in hippocampus of human postmortem brain samples.
Glutamate Transporters
(click on image to enlarge)
Effects of antipsychotic medication
Other molecules involved in glutamate neurotransmission
Molecules associated with dopaminergic neurotransmission
