Professor of Medicine
Medical Director, Vascular Biology and Hypertension Program


Contact Information
Biomedical Research Building II, Room 430
1530 3rd Avenue South
Birmingham Alabama 35294-2180





Post-Docoral Fellowship in Hypertension
University of Alabama at Birmingham (1989-1991)

Internal Medicine Residency
University of Alabama at Birmingham  (1987-1989)

Medical Degree
University of Virginia School of Medicine  (1982 - 1986)

Board Certifications

American Board of Internal Medicine – Sleep Specialist (2005)
American Society of Hypertension (1998)
American Board of Medical Examiners (1989)   




 Clinical Interests

Renovascular hypertension
Sleep/wake disorders




Research Interests

Identifying hyperaldosteronism as a common cause of resistant hypertension
Demonstrating the broad benefit of mineralocorticoid receptor antagonism to treat resistant hypertension
Establishing that a high degree of salt sensitivity contributes importantly to resistance to antihypertensive therapies
Identifying aldosterone excess as an important mediator of severity of obstructive sleep apnea in patients with resistant hypertension
Demonstrating the ability of aldosterone antagonism to reduce severity of obstructive sleep apnea in patients with resistant hypertension

Selected Journal


Pimenta E, Calhoun DA. Resistant Hypertension: Incidence, Prevalence and Prognosis. Circulation. 2012 Feb 29. [Epub ahead of print]
PMID: 22379111

Clark D, Guichard JL, Calhoun DA, Ahmed MI. Recent advancements in the treatment of resistant hypertension. Postgrad Med. 2012 Jan;124(1):67-73.
PMID: 22314116

Acelajado MC, Pisoni R, Dudenbostel T, Dell'Italia LJ, Cartmill F, Zhang B, Cofield SS, Oparil S, Calhoun DA. Refractory hypertension: definition, prevalence, and patient characteristics.J Clin Hypertens (Greenwich). 2012 Jan;14(1):7-12. doi: 10.1111/j.1751-7176.2011.00556.x. Epub 2011 Nov 15.
PMID: 22235818

Judd E, Calhoun DA. Hypertension and orthostatic hypotension in older patients. J Hypertens. 2012 Jan;30(1):38-9. No abstract available.
PMID: 22157584 

Textor SC, Gloviczki ML, Flessner MF, Calhoun DA, Glockner J, Grande JP, McKusick MA, Cha SS, Lerman LO. Association of filtered sodium load with medullary volumes and medullary hypoxia in hypertensive African Americans as compared with whites. Am J Kidney Dis. 2012 Feb;59(2):229-37. Epub 2011 Nov 29.
PMID: 22130642

PubMed Listings

David Calhoun, MD