C. elegans Cilia and CKD Related Mutations and Transgenic Lines Available in Core B

Mammalian Gene Name

Human Disease Gene

C. elegansHomolog

Mutant Strain Available  in Core B

C. elegans Mutant Phenotype(s)

Transgenic Fusion Line

Protein Localization

KIF3A

klp-20

No

ND

Cilia

IFT20

ift-20

Yes

AC, Che, Dyf, L, M

GFP / CFP

Cilia

IFT52

che-13

Yes

AC, Che, Dyf, L, M

CFP/YFP

Cilia

IFT81

Yes

ift-81

Yes

AC, Che, Dyf, L, M

IFT88

osm-5

Yes

AC, Che, F, Dyf, L, M

GFP/CFP/YFP

Cilia

IFT122

daf-10

Yes

AC, Che, Dyf, L, M

IFT140

che-11

Yes

AC, Che, Dyf, L, M

YFP

Cilia

IFT172

osm-1

Yes

AC, Che, Dyf, L, M

CFP/YFP

Cilia

TRAF3IP

dyf-11

Yes

AC, Che, Dyf

GFP

Cilia

CLAUP1

dyf-3

Yes

AC, Che, Dyf

RABL5

ifta-2

Yes

F, L

GFP

Cilia

PKD1

Yes

lov-1

Yes

M

Male Cilia

PKD2

Yes

pkd-2

Yes

M

GFP

Male Cilia

MKS1

Yes

mks-1

Yes

YFP/RFP

Base of Cilia

B9D1 (mksr2)

mksr-1

Yes

F, L

CFP/RFP

Base of Cilia

B9D2/ 
stumpy 
Mksr1

mksr-2

Yes

F, L

YFP/RFP

Base of Cilia

MKS3 
(Meckelin)

Yes

mks-3

Yes

Che

GFP/RFP

Base of Cilia

MKS5 
(RPGRIP1L)

Yes

mks-5

Yes

ND

RFP

Base of Cilia

MKS6

Yes

mks-6

Yes

ND

GFP

Base of Cilia

NPHP1

Yes

nphp-1

Yes

Che, F, L

CFP/RFP

Base of Cilia

NPHP2 
inversin

Yes

nphp-2

Yes

Dyf

GFP

Base of Cilia

NPHP4

Yes

nphp-4

Yes

Che, F, L

YFP

Base of Cilia

NPHP9/NEK8

nekl-1

No

ND

BBS1

Yes

bbs-1

No

ND

GFP

Cilia

BBS2

Yes

bbs-2

No

ND

BBS3

Yes

arl-6

No

ND

BBS4

Yes

F58A4.14

No

ND

BBS5

Yes

bbs-5

No

ND

Cilia

BBS7

Yes

osm-12

Yes

Che, Dyf

GFP

Cilia

BBS8

Yes

bbs-8

Yes

Che, Dyf

GFP

Cilia

BBS9

Yes

bbs-9

No

ND

JBTS1

Yes

cil-1

No

ND

JBTS8/ 
Henin

Yes

arl-13b

No

ND

GFP

Cilia



# Mutant line is not currently in Core B but is available through the C. elegans Genetic Center

Phenotypes: AC- Absent Cilia, Che –Chemotaxis or Osmotic Avoidance, F-Foraging, Dyf –Dye filling defective, L – Lifespan, M- Male mating defective, ND- Phenotype Not Determined