Cystic Kidney and Cilia Related Mouse Lines Generated or Available in Core B

Gene

Clone #

Source

Mutation Type

Human Disease

Status/ 
Null Phenotype

Availability

Disease Complex or Function

# of Chimeras

MKS Alleles

B9d1

Eppb9

Eucomm

Conditional

MKS

E. Lethal

 Available

MKS complex

20

Mks1

C7, D9

Eucomm

Conditional

MKS

Chimera/ Injecting

NA

MKS complex

1

Cc2d2a 
(Mks-6)

AA0274

MMRRC

Gene Trap

MKS

Lethal

 In Quality Control

MKS Complex

11

Cc2d2a 
(Mks6)

C03 
A06

Eucomm

Conditional

MKS

Chimera/ Injecting

NA

MKS Complex

3

RpGrip1L 
(Mks-5)

A04, A02, A01

Eucomm

Conditional

MKS

Chimera/ Injecting

NA

MKS Complex

1

NPHP Alleles

Nphp1

JM8.N4

Eucomm

Conditional

NPHP

Chimera

 NA

NPHP Complex

5

Nphp4

C57BL/ 6J-nmf192/J

Jackson Labs

Chemical

NPHP

Male sterile and blind

Jackson Labs

NPHP Complex

NA

BBS Alleles

BBS4

Bbs4tm1Vcs/J

Jackson Labs

KO

BBS

Viable Obese

Jackson Labs

BBSome

NA

BBS9

CSH755

MMRRC

Gene Trap

BBS

Germline/ 
Being Analyzed

 In Quality Control

BBSome

6

IFT Alleles

Ift140

F01

Komp

Conditional

 

Viable

  In Quality Control

IFT  Complex A

8

Cluap1 
(Dyf3)

B01

Komp

Conditional

 

Early Gestational  Lethal

 Available

 IFT Complex B

4

TRAF-3IP 
(IFT54)

Rj0005

MMRRC

Gene Trap

 

Early Gestational  Lethal

 Available

IFT Complex B

3

IFT88 Flox

Target at UAB

UAB

Conditional

 

Viable

Available

IFT Complex B

4

IFT88-ORPK

NA

ORNL

Insertional Mutant

 

Viable- Cystic Disease

Available

IFT 
Complex B

NA

IFT88-KO

NA

ORNL

Null

 

Germline/ Lethal

Available

IFT 
Complex B

NA

Cilia Proteome Gene Alleles

Ccdc42

ADL2

Komp

Target Null

 

Viable

Male Sterile

 Unknown

7

Rabl4 
(IFT27)

14917 A-A12, 14917A-F5

Komp

Target Null

 

Perinatal Lethal

Available

Unknown

NA

Rabl4 
(IFT27)

E10

Eucomm

Conditional

 

Chimera

NA

NA

NA

Rabl5

AC7

Komp

Target Null

 

Viable

 Available

IFT Associated

NA

D430042009Rik

RRG309

MMRRC

Gene Trap

 

Early Postnatal Lethal- Hydrocephalic

 Available

Unknown

3

Gtl3

XA021

MMRRC

Gene Trap

 

Early Lethal

 Available

Unknown

8

Gas8

CH0760

MMRRC

Gene Trap

 

Early Postnatal Lethal - Hydrocephalic

 Available

 Dynein Regulator Complex

4

Tcf712

 

Eucomm

Conditional

 

Chimeras

NA

Tsc. Factor

9

Septin-2

 

Eucomm

Conditional

 

Injecting

NA

Cilia diffusion barrier

 

Other Cilia Related Mouse Lines

SSTR3-GFP Tag

NA

UAB

Conditional Expression

 

Germline

NA

Inducible Cilia Tag Mouse

8