Pilot and Feasibility studies in Hepato/Renal Fibrocystic Disease

The UAB Hepato/Renal Fibrocystic Disease Core Center (UAB HRFDCC; P30 DK074038) invites brief proposals for Pilot and Feasibility studies in basic and translational research related to HRFD.

The P&F Program provides support for eligible innovative investigators with the goal of generating preliminary data for subsequent funding through traditional mechanisms (e.g., NIH R01). Successful proposals will be supported for one year beginning July 1, 2014. A second year of support will be considered upon resubmission of a research application and competitive review of the previous year’s progress.


Investigators eligible for NIH funding ( with a faculty appointment before July 1, 2014 who fall into one of two categories:

1. Established investigators who want to explore a novel idea or concept related to HRFD that represents a clear departure from the investigator’s ongoing research efforts. Investigators currently funded in the area of HRFDresearch (e.g., hepato/renal ciliopathies such as polycystic kidney disease) are not eligible.

2. New independent investigators without current or past NIH research support (R mechanism), who have an interest in establishing a career in HRFD-related research.


Maximum $50,000 per year in direct costs for a one-year grant period must include:

  • The limit on faculty salary support (PI, any faculty level collaborators) is 0.1 FTE (1.2 cal months) per faculty member
  • Cost of travel expenses related to travel and presentation at UAB HRFD (no more than $1,500).
    No indirect costs are allowed.


Submission of P&Fs to the Center is a two-stage process with internal and external review:

1. Letter of Intent due by February 17, 2014 should include in separate sections: Overall objectives, Specific aims, Significance of the proposed research to HRFD, Research plan (including brief methodology) and eligibility justification. References are not included in a 2-page page limit. Use of HRFDCC cores is particularly encouraged and use of cores should be explicitly described. Projects unrelated to HRFD basic or translational research will not receive further consideration.

NIH Biographical Sketch with Other Support, and a one-page budget summary should be included.

Applicants will be notified by March 23, 2014 as to whether they are selected for full proposal submission.

2. Proposal due by Monday, May 5, 2014 on PHS 398 forms according to NIH guidelines should include: Cover Page with signatures, Abstract (up to 250 words), NIH style 4 page biosketch, Specific Aims (1 page limit), one year detailed budget, Budget Justification (1 page limit), and Research proposal (4 page limit) containing a) background and significance to HRFD, b) preliminary data, and c) research plan. In addition, please provide a description of HRFD CC core utilization and justification of your eligibility for this award (prior R funding, new area, etc) (1 page limit). There is no page limit on References.

For each stage, the requested documents contained within a single PDF file must be submitted as an email attachment to Rene Eubank:

For additional information, contact Bradley Yoder (, Michal Mrug ( or Joanne Murphy-Ullrich (