A Phase III, Randomized, Multicenter, Double-Bling, Placebo-Controlled Clinical Trial of Omalizumab in Patients with Chronic Rhinosinusitis with Nasal Polyps

The purpose of this study is to determine the efficacy and safety of omalizumab compared with placebo in adult participants with chronic rhinosinusitis with nasal polyps (CRSwNP) who have had inadequate response to standard-of-care treatments.

Principal Investigators: Do-Yeon Cho, MD

Adherence and Outcome of Upper Airway Stimulation (UAS) for OSA International Registry

The purpose of this registry is to gather information on how the Inspire Upper Airway System (Inspire system) is used and performs for patients in the commercial setting. In addition, the information collected will continue to educate physicians who treat obstructive sleep apnea (OSA).

Principal Investigator: Kirk Withrow, MD

Inspire® Upper Airway Stimulation (UAS) System: Post Approval Study

The purpose of this study is to gather information in the post approval setting on how the Inspire Airway System (Inspire system) works and assess patient outcomes.

Principal Investigator: Kirk Withrow, MD

Prospective Observational Study to Evaluate Outcomes from Trans-oral Base of Tongue Resection for Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)

The purpose of this study is to evaluate the use of robotic-assisted surgery for better visibility and access for trans-oral base of tongue resection, a common treatment for obstructive sleep apnea.

Principal Investigator: Kirk Withrow, MD

Invacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis (EDSPD Protocol)

The purpose of this study is to establish the novel endoscopically-directed sinus potential difference (EDSPD) assay as an endpoint for therapy of sinus disease. This assay provides a means to measure CI-secretion across the sinus epithelium in human subjects with chronic rhinosinusitis (CRS) and test the relationship between this data and endoscopic findings of inflammation. 

Principal Investigator: Bradford Woodworth, MD

Chloride Secretagogues for Acquired CFTR Dysfunction in Chronic Rhinosinusitis (NPD Protocol)

The purpose of this study is to determine if acquired (partial) Cystic Fibrosis Transmembrane conductance Regulator (CFTR) deficiency contributes substantially to the pathogenic mechanisms underlying Chronic Rhinosinusitis (CRS), creating a localized environment that impairs mucociliary clearance (MCC).

Principal Investigator: Bradford Woodworth, MD