• JainAssistant Professor of Medicine
    Division of Clinical Immunology & Rheumatology

    Address: 
     

    Faculty Office Tower, room 834
    510 20th Street South
    35294-2182

    Telephone:(205) 934-1532

     

    Education

    MD,Maulana Azad Medical College, Delhi University, New Delhi, India, 2001
    Internship(Internal Medicine), St. Francis Hospital, Evanston, IL, 2003-2004
    Residency (Internal Medicine), St. Francis Hospital, Evanston, IL, 2004-2005
    Chief Resident (Internal Medicine), St. Francis Hospital, Evanston, IL, 2005-2006

     

    Research and Clinical Interests

    Clinical interests include inflammatory arthritis, SLE, vasculitides, inflammatory myopathies, utilization of musculoskeletal ultrasound as a tool for evaluation of rheumatic disease. Main research interest is the safety of biological therapies in rheumatic diseases.

     

    Selected Publications

    Singh JA, Furst DE, Bharat A, Curtis JR, Kavanaugh AF, Kremer JM, Moreland LW, O'Dell J, Winthrop KL, Beukelman T, Bridges SL Jr, Chatham WW, Paulus HE, Suarez-Almazor M, Bombardier C, Dougados M, Khanna D, King CM, Leong AL, Matteson EL, Schousboe JT, Moynihan E, Kolba KS, Jain A, Volkmann ER, Agrawal H, Bae S, Mudano AS, Patkar NM, Saag KG. 2012. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res (Hoboken). 64(5):625-39. PMCID: PMC4081542


    Singh JA, Furst DE, Bharat A, Curtis JR, Kavanaugh AF, Kremer JM, Moreland LW, O'Dell J, Winthrop KL, Beukelman T, Bridges SL Jr, Chatham WW, Paulus HE, Suarez-Almazor M, Bombardier C, Dougados M, Khanna D, King CM, Leong AL, Matteson EL, Schousboe JT, Moynihan E, Kolba KS, Jain, A, Volkman, ER, Agrawal, H, Bae, S, Mudano, AS, Patkar, NM, Saag, KG.2012 Update of the 2008 American College of Rheumatology (ACR) Recommendations for the use of Disease-Modifying Anti-Rheumatic Drugs (DMARDs) and Biologics in the treatment of Rheumatoid Arthritis (RA). Arthritis Care Res64(5):625-39. PMID: 22473917


    Curtis JR, Jain A, Askling J, Bridges SL Jr, Carmona L, Dixon W, Finckh A et al. 2010. A Comparison of Patient Characteristics and Outcomes in Selected European and U.S. Rheumatoid Arthritis Registries. Semin Arthritis Rheum.40(1):2-14.e1.PMID: 20674669


    Curtis JR, Patkar NM, Jain A, Greenberg J, Solomon DH. 2009. The Validity of Physician-Reported Hospitalized Infections in an Observational U.S. Arthritis Registry. Rheumatology (Oxford).48(10):1269-72. PMID: 19654217

     

     

  • JunLi Updated 2013Instructor of Medicine

    Division of Clinical Immunology and Rheumatology

    Address:

    Shelby Building, Suite 337
    1825 University Boulevard
    Birmingham, AL 35294-2182

    Telephone: (205) 934-8909

    Fax: (205) 996-6788

    Email: junli@uabmc.edu

     

    Education:

    M.D.Sun Yat-sen University, School of Medicine, Guangzhou, China 1997
    Ph.D.(Physiology): University of Alabama at Birmingham, 2008
    Postdoctoral Fellow: Department of Medicine, Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, 2012

     

    Research Interests

    Macrophages in pathogenesis of rheumatoid arthritis (RA) and development of novel macrophage target therapies in RA; Identification of novel markers (death receptor, et al) of M1 inflammatory macrophages in RA;


    figure-1

    Roles of fucosylation in regulation of macrophage differentiation, apoptosis, antigen presentation, cytoskeleton rearrangement, and how these are linked to pathogenesis of RA; efficacy and mechanisms of fucosylation inhibitors in the treatment of RA and other autoimmune diseases;

    figure-2-2

    Studies of inflammatory IRF5+ macrophages and GM-CSF+ CD4 T cell interaction in RA using synovial fluid and PBMC from RA subjects. 


    Figure-3-2

     

    Publications

    Click here for a more complete list of publications. Below are selected papers


    Li J,
    Hsu HC, Ding Y, Li H, Wu Q, Yang P, Luo B, Rowse AL, Spalding DM, Bridges SL Jr, Mountz JD. 2014. Inhibition of fucosylation reshapes inflammatory macrophages and suppresses type II collagen-induced arthritis. Arthritis Rheumatol. 66(9):2368-79. PMC4146698


    Li J, Yang PA, Wu Q, Li, H, Ding Y, Hsu H-C, Spalding DM, and Mountz JD. 2013. Death receptor 5-targeted depletion of interleukin 23 producing macrophages, Th17, and Th1/17 associated with defective tyrosine phosphatase in mice and patients with rheumatoid arthritis. Arthritis & Rheum 65(10), 2594-2605. (Supplementary Table). PMC3993980


    Li J
    , Hsu H-C, and Mountz JD.  2012. Managing Macrophage in Rheumatoid Arthritis by Reform or Removal. Curr Rheumatol Rep. 14 (5):445-54. PMID: 22855296


    Li J
    , Hsu H-C, Yang P, Wu Q, Li H,  Edgington LE, Bogyo M, Kimberly RP, and Mountz JD.  2012. Treatment of Arthritis by Macrophage Depletion and Immunomodulation: Testing an Apoptosis-Mediated Therapy in a Humanized Death Receptor Mouse Model. Arthritis Rheum. 64(4):1098-109.  PMID: 22006294